Dynamic Combinatorial Mass Spectrometry Leads to Inhibitors of a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

2-Oxoglutarate-dependent nucleic acid demethylases are of biological interest because of their roles in nucleic acid repair and modification. Although some of these enzymes are linked to physiology, their regulatory roles are unclear. Hence, there is a desire to develop selective inhibitors for them...

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Veröffentlicht in:	Journal of medicinal chemistry 2012-03, Vol.55 (5), p.2173-2184
Hauptverfasser:	Woon, Esther C. Y, Demetriades, Marina, Bagg, Eleanor A. L, Aik, WeiShen, Krylova, Svetlana M, Ma, Jerome H. Y, Chan, MunChiang, Walport, Louise J, Wegman, David W, Dack, Kevin N, McDonough, Michael A, Krylov, Sergey N, Schofield, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalytic Domain Combinatorial Chemistry Techniques Crystallography, X-Ray Cysteine - analogs & derivatives Cysteine - chemical synthesis Cysteine - chemistry Enzyme Assays Escherichia coli Proteins - antagonists & inhibitors Escherichia coli Proteins - chemistry Ferrous Compounds - chemistry Ferrous Compounds - metabolism Ketoglutaric Acids - chemistry Ketoglutaric Acids - metabolism Mixed Function Oxygenases - antagonists & inhibitors Mixed Function Oxygenases - chemistry Models, Molecular Protein Binding Pyridines - chemical synthesis Pyridines - chemistry Quinolines - chemical synthesis Quinolines - chemistry Spectrometry, Mass, Electrospray Ionization Structure-Activity Relationship
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