Protein kinase C delta contributes to increase in EP3 agonist-induced contraction in mesenteric arteries from type 2 diabetic Goto-Kakizaki rats

Prostaglandin E 2 (PGE 2 ), an important and ubiquitously present vasoactive eicosanoid, may either constrict or dilate systemic vascular beds. However, little is known about the vascular contractile responsiveness to and signaling pathways for PGE 2 at the chronic stage of type 2 diabetes. We hypot...

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Veröffentlicht in:	Pflügers Archiv 2012-04, Vol.463 (4), p.593-602
Hauptverfasser:	Ishida, Keiko, Matsumoto, Takayuki, Taguchi, Kumiko, Kamata, Katsuo, Kobayashi, Tsuneo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Calmodulin-Binding Proteins - metabolism Cell Biology Diabetes Mellitus, Type 2 - enzymology Diabetes Mellitus, Type 2 - physiopathology Dinoprostone - analogs & derivatives Dinoprostone - metabolism Dinoprostone - pharmacology Human Physiology Male Mesenteric Arteries - drug effects Mesenteric Arteries - physiopathology Molecular and Cellular Mechanisms of Disease Molecular Medicine Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Neurosciences Phosphorylation Protein Kinase C-delta - metabolism Rats Rats, Wistar Receptors Receptors, Prostaglandin E, EP3 Subtype - agonists Receptors, Prostaglandin E, EP3 Subtype - metabolism Vasoconstriction - drug effects Vasoconstrictor Agents - pharmacology
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