Evolution of Lipid Profiles after Bariatric Surgery
Background The most commonly encountered dyslipidemia in obese individuals is characterized by a cluster of interrelated plasma lipid and lipoprotein abnormalities including hypertriglyceridemia, low HDL cholesterol values, and increased small, dense LDL cholesterol particles. The aim of this study...
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| Veröffentlicht in: | Obesity surgery 2012-04, Vol.22 (4), p.609-616 |
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| creator | Garcia-Marirrodriga, Ignacio Amaya-Romero, Cesar Ruiz-Diaz, Gabriel Patiño Férnandez, Sandra Ballesta-López, Carlos Pou, Jose Ma Romeo, June H. Vilhur, Gemma Badimon, Lina Ybarra, Juan |
| description | Background
The most commonly encountered dyslipidemia in obese individuals is characterized by a cluster of interrelated plasma lipid and lipoprotein abnormalities including hypertriglyceridemia, low HDL cholesterol values, and increased small, dense LDL cholesterol particles. The aim of this study was to assess the changes in lipid profiles at baseline (pre-operatively) and at follow-up (6, 12, and 18 months) after a laparoscopic Roux-en-Y gastric bypass (LRYGBP). A retrospective observational study was performed involving all patients who consecutively underwent a LRYGBP between January 1, 2007 and December 31, 2009. Fasting lipids sub-fractions (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides) were measured and HOMA-IR calculated pre-operatively and at follow-up post-LRYGBP. Pearson’s correlation coefficients were used to assess the relationship between excess weight loss (EWL) and lipid sub-fractions. ANOVA was used to assess the differences between each lipid sub-fraction at various time-points.
Methods
One hundred twenty eight (
N
= 128) medical charts were reviewed, and those containing data on lipid fractions at the three follow-up time-points were analyzed. One hundred fourteen patients (
N
= 114), 84 of whom were women (73.7%), were finally included in the study.
Results
Total cholesterol, LDL cholesterol, triglycerides, and HOMA-IR were significantly reduced after LRYGBP (
P
|
| doi_str_mv | 10.1007/s11695-011-0534-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_927687054</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2605472331</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-f55a0ec3d349ece4f3c4a6acdfdc9e2f115c2d98334a2c8da77dc41e2a8ef2c43</originalsourceid><addsrcrecordid>eNp1kMtKAzEUhoMotlYfwI0MblxFc5tJstRSL1BQUNch5iIp00lNZoS-vTNMVRBcncX5_v8cPgBOMbrECPGrjHElS4gwhqikDPI9MMUcCYgYEftgimSFoJCETsBRziuECK4IOQQTQhAVJaVTQBefse7aEJsi-mIZNsEWTyn6ULtcaN-6VNzoFHSbgimeu_Tu0vYYHHhdZ3eymzPwert4md_D5ePdw_x6CQ3lqIW-LDVyhlrKpDOOeWqYrrSx3hrpiMe4NMRKQSnTxAirObeGYUe0cJ4YRmfgYuzdpPjRudyqdcjG1bVuXOyykoRXgqNyIM__kKvYpaZ_rocqiQnDA4RHyKSYc3JebVJY67RVGKnBpxp9qt6nGnwq3mfOdsXd29rZn8S3wB4gI5D7VdPb-b38f-sX7Cx_ow</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>926912414</pqid></control><display><type>article</type><title>Evolution of Lipid Profiles after Bariatric Surgery</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Garcia-Marirrodriga, Ignacio ; Amaya-Romero, Cesar ; Ruiz-Diaz, Gabriel Patiño ; Férnandez, Sandra ; Ballesta-López, Carlos ; Pou, Jose Ma ; Romeo, June H. ; Vilhur, Gemma ; Badimon, Lina ; Ybarra, Juan</creator><creatorcontrib>Garcia-Marirrodriga, Ignacio ; Amaya-Romero, Cesar ; Ruiz-Diaz, Gabriel Patiño ; Férnandez, Sandra ; Ballesta-López, Carlos ; Pou, Jose Ma ; Romeo, June H. ; Vilhur, Gemma ; Badimon, Lina ; Ybarra, Juan</creatorcontrib><description>Background
The most commonly encountered dyslipidemia in obese individuals is characterized by a cluster of interrelated plasma lipid and lipoprotein abnormalities including hypertriglyceridemia, low HDL cholesterol values, and increased small, dense LDL cholesterol particles. The aim of this study was to assess the changes in lipid profiles at baseline (pre-operatively) and at follow-up (6, 12, and 18 months) after a laparoscopic Roux-en-Y gastric bypass (LRYGBP). A retrospective observational study was performed involving all patients who consecutively underwent a LRYGBP between January 1, 2007 and December 31, 2009. Fasting lipids sub-fractions (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides) were measured and HOMA-IR calculated pre-operatively and at follow-up post-LRYGBP. Pearson’s correlation coefficients were used to assess the relationship between excess weight loss (EWL) and lipid sub-fractions. ANOVA was used to assess the differences between each lipid sub-fraction at various time-points.
Methods
One hundred twenty eight (
N
= 128) medical charts were reviewed, and those containing data on lipid fractions at the three follow-up time-points were analyzed. One hundred fourteen patients (
N
= 114), 84 of whom were women (73.7%), were finally included in the study.
Results
Total cholesterol, LDL cholesterol, triglycerides, and HOMA-IR were significantly reduced after LRYGBP (
P
< 0.0005 for all). Inversely, HDL cholesterol disclosed a significant rise (
P
< 0.0005). Noteworthy significant associations between lipid subfractions and EWL were detected overall (
P
< 0.0005 for all). A gender effect was found since female patients displayed a milder association than male patients (
P
< 0.0005).
Conclusions
LRYGBP-induced weight loss improves the lipid profile while reducing insulin resistance, with male patients showing a better profile than female patients.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-011-0534-7</identifier><identifier>PMID: 22038533</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adult ; Analysis of Variance ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Clinical Research ; Female ; Follow-Up Studies ; Gastric Bypass - methods ; Gastrointestinal surgery ; Humans ; Hyperlipidemias - blood ; Hyperlipidemias - epidemiology ; Lipids ; Lipids - blood ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Obesity ; Obesity, Morbid - blood ; Obesity, Morbid - epidemiology ; Pilot Projects ; Postoperative Period ; Preoperative Period ; Retrospective Studies ; Spain - epidemiology ; Surgery ; Treatment Outcome ; Triglycerides - blood ; Weight Loss ; Young Adult</subject><ispartof>Obesity surgery, 2012-04, Vol.22 (4), p.609-616</ispartof><rights>Springer Science + Business Media, LLC 2011</rights><rights>Springer Science + Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-f55a0ec3d349ece4f3c4a6acdfdc9e2f115c2d98334a2c8da77dc41e2a8ef2c43</citedby><cites>FETCH-LOGICAL-c370t-f55a0ec3d349ece4f3c4a6acdfdc9e2f115c2d98334a2c8da77dc41e2a8ef2c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-011-0534-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-011-0534-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22038533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia-Marirrodriga, Ignacio</creatorcontrib><creatorcontrib>Amaya-Romero, Cesar</creatorcontrib><creatorcontrib>Ruiz-Diaz, Gabriel Patiño</creatorcontrib><creatorcontrib>Férnandez, Sandra</creatorcontrib><creatorcontrib>Ballesta-López, Carlos</creatorcontrib><creatorcontrib>Pou, Jose Ma</creatorcontrib><creatorcontrib>Romeo, June H.</creatorcontrib><creatorcontrib>Vilhur, Gemma</creatorcontrib><creatorcontrib>Badimon, Lina</creatorcontrib><creatorcontrib>Ybarra, Juan</creatorcontrib><title>Evolution of Lipid Profiles after Bariatric Surgery</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Background
The most commonly encountered dyslipidemia in obese individuals is characterized by a cluster of interrelated plasma lipid and lipoprotein abnormalities including hypertriglyceridemia, low HDL cholesterol values, and increased small, dense LDL cholesterol particles. The aim of this study was to assess the changes in lipid profiles at baseline (pre-operatively) and at follow-up (6, 12, and 18 months) after a laparoscopic Roux-en-Y gastric bypass (LRYGBP). A retrospective observational study was performed involving all patients who consecutively underwent a LRYGBP between January 1, 2007 and December 31, 2009. Fasting lipids sub-fractions (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides) were measured and HOMA-IR calculated pre-operatively and at follow-up post-LRYGBP. Pearson’s correlation coefficients were used to assess the relationship between excess weight loss (EWL) and lipid sub-fractions. ANOVA was used to assess the differences between each lipid sub-fraction at various time-points.
Methods
One hundred twenty eight (
N
= 128) medical charts were reviewed, and those containing data on lipid fractions at the three follow-up time-points were analyzed. One hundred fourteen patients (
N
= 114), 84 of whom were women (73.7%), were finally included in the study.
Results
Total cholesterol, LDL cholesterol, triglycerides, and HOMA-IR were significantly reduced after LRYGBP (
P
< 0.0005 for all). Inversely, HDL cholesterol disclosed a significant rise (
P
< 0.0005). Noteworthy significant associations between lipid subfractions and EWL were detected overall (
P
< 0.0005 for all). A gender effect was found since female patients displayed a milder association than male patients (
P
< 0.0005).
Conclusions
LRYGBP-induced weight loss improves the lipid profile while reducing insulin resistance, with male patients showing a better profile than female patients.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Clinical Research</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastric Bypass - methods</subject><subject>Gastrointestinal surgery</subject><subject>Humans</subject><subject>Hyperlipidemias - blood</subject><subject>Hyperlipidemias - epidemiology</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity, Morbid - blood</subject><subject>Obesity, Morbid - epidemiology</subject><subject>Pilot Projects</subject><subject>Postoperative Period</subject><subject>Preoperative Period</subject><subject>Retrospective Studies</subject><subject>Spain - epidemiology</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Triglycerides - blood</subject><subject>Weight Loss</subject><subject>Young Adult</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kMtKAzEUhoMotlYfwI0MblxFc5tJstRSL1BQUNch5iIp00lNZoS-vTNMVRBcncX5_v8cPgBOMbrECPGrjHElS4gwhqikDPI9MMUcCYgYEftgimSFoJCETsBRziuECK4IOQQTQhAVJaVTQBefse7aEJsi-mIZNsEWTyn6ULtcaN-6VNzoFHSbgimeu_Tu0vYYHHhdZ3eymzPwert4md_D5ePdw_x6CQ3lqIW-LDVyhlrKpDOOeWqYrrSx3hrpiMe4NMRKQSnTxAirObeGYUe0cJ4YRmfgYuzdpPjRudyqdcjG1bVuXOyykoRXgqNyIM__kKvYpaZ_rocqiQnDA4RHyKSYc3JebVJY67RVGKnBpxp9qt6nGnwq3mfOdsXd29rZn8S3wB4gI5D7VdPb-b38f-sX7Cx_ow</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Garcia-Marirrodriga, Ignacio</creator><creator>Amaya-Romero, Cesar</creator><creator>Ruiz-Diaz, Gabriel Patiño</creator><creator>Férnandez, Sandra</creator><creator>Ballesta-López, Carlos</creator><creator>Pou, Jose Ma</creator><creator>Romeo, June H.</creator><creator>Vilhur, Gemma</creator><creator>Badimon, Lina</creator><creator>Ybarra, Juan</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120401</creationdate><title>Evolution of Lipid Profiles after Bariatric Surgery</title><author>Garcia-Marirrodriga, Ignacio ; Amaya-Romero, Cesar ; Ruiz-Diaz, Gabriel Patiño ; Férnandez, Sandra ; Ballesta-López, Carlos ; Pou, Jose Ma ; Romeo, June H. ; Vilhur, Gemma ; Badimon, Lina ; Ybarra, Juan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-f55a0ec3d349ece4f3c4a6acdfdc9e2f115c2d98334a2c8da77dc41e2a8ef2c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Clinical Research</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastric Bypass - methods</topic><topic>Gastrointestinal surgery</topic><topic>Humans</topic><topic>Hyperlipidemias - blood</topic><topic>Hyperlipidemias - epidemiology</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity, Morbid - blood</topic><topic>Obesity, Morbid - epidemiology</topic><topic>Pilot Projects</topic><topic>Postoperative Period</topic><topic>Preoperative Period</topic><topic>Retrospective Studies</topic><topic>Spain - epidemiology</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><topic>Triglycerides - blood</topic><topic>Weight Loss</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia-Marirrodriga, Ignacio</creatorcontrib><creatorcontrib>Amaya-Romero, Cesar</creatorcontrib><creatorcontrib>Ruiz-Diaz, Gabriel Patiño</creatorcontrib><creatorcontrib>Férnandez, Sandra</creatorcontrib><creatorcontrib>Ballesta-López, Carlos</creatorcontrib><creatorcontrib>Pou, Jose Ma</creatorcontrib><creatorcontrib>Romeo, June H.</creatorcontrib><creatorcontrib>Vilhur, Gemma</creatorcontrib><creatorcontrib>Badimon, Lina</creatorcontrib><creatorcontrib>Ybarra, Juan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia-Marirrodriga, Ignacio</au><au>Amaya-Romero, Cesar</au><au>Ruiz-Diaz, Gabriel Patiño</au><au>Férnandez, Sandra</au><au>Ballesta-López, Carlos</au><au>Pou, Jose Ma</au><au>Romeo, June H.</au><au>Vilhur, Gemma</au><au>Badimon, Lina</au><au>Ybarra, Juan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evolution of Lipid Profiles after Bariatric Surgery</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>22</volume><issue>4</issue><spage>609</spage><epage>616</epage><pages>609-616</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Background
The most commonly encountered dyslipidemia in obese individuals is characterized by a cluster of interrelated plasma lipid and lipoprotein abnormalities including hypertriglyceridemia, low HDL cholesterol values, and increased small, dense LDL cholesterol particles. The aim of this study was to assess the changes in lipid profiles at baseline (pre-operatively) and at follow-up (6, 12, and 18 months) after a laparoscopic Roux-en-Y gastric bypass (LRYGBP). A retrospective observational study was performed involving all patients who consecutively underwent a LRYGBP between January 1, 2007 and December 31, 2009. Fasting lipids sub-fractions (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides) were measured and HOMA-IR calculated pre-operatively and at follow-up post-LRYGBP. Pearson’s correlation coefficients were used to assess the relationship between excess weight loss (EWL) and lipid sub-fractions. ANOVA was used to assess the differences between each lipid sub-fraction at various time-points.
Methods
One hundred twenty eight (
N
= 128) medical charts were reviewed, and those containing data on lipid fractions at the three follow-up time-points were analyzed. One hundred fourteen patients (
N
= 114), 84 of whom were women (73.7%), were finally included in the study.
Results
Total cholesterol, LDL cholesterol, triglycerides, and HOMA-IR were significantly reduced after LRYGBP (
P
< 0.0005 for all). Inversely, HDL cholesterol disclosed a significant rise (
P
< 0.0005). Noteworthy significant associations between lipid subfractions and EWL were detected overall (
P
< 0.0005 for all). A gender effect was found since female patients displayed a milder association than male patients (
P
< 0.0005).
Conclusions
LRYGBP-induced weight loss improves the lipid profile while reducing insulin resistance, with male patients showing a better profile than female patients.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>22038533</pmid><doi>10.1007/s11695-011-0534-7</doi><tpages>8</tpages></addata></record> |
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| ispartof | Obesity surgery, 2012-04, Vol.22 (4), p.609-616 |
| issn | 0960-8923 1708-0428 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Analysis of Variance Cholesterol, HDL - blood Cholesterol, LDL - blood Clinical Research Female Follow-Up Studies Gastric Bypass - methods Gastrointestinal surgery Humans Hyperlipidemias - blood Hyperlipidemias - epidemiology Lipids Lipids - blood Male Medicine Medicine & Public Health Middle Aged Obesity Obesity, Morbid - blood Obesity, Morbid - epidemiology Pilot Projects Postoperative Period Preoperative Period Retrospective Studies Spain - epidemiology Surgery Treatment Outcome Triglycerides - blood Weight Loss Young Adult |
| title | Evolution of Lipid Profiles after Bariatric Surgery |
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