Recombinant Human Angiopoietin-1 Ameliorates the Expressions of ZO-1, Occludin, VE-cadherin, and PKCα Signaling after Focal Cerebral Ischemia/Reperfusion in Rats

This study was performed to determine whether recombinant human angiopoietin-1 (Ang-1) decreases the permeability of the blood–brain barrier (BBB) in focal cerebral ischemia and reperfusion rats, whether Ang-1 opens the BBB by affecting tight junction associated proteins zonula occluden-1 (ZO-1), oc...

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Veröffentlicht in:	Journal of molecular neuroscience 2012-01, Vol.46 (1), p.236-247
Hauptverfasser:	Yu, Hang, Wang, Ping, An, Ping, Yixue, Xue
Format:	Artikel
Sprache:	eng
Schlagworte:	adherens junctions Angiopoietin-1 - genetics Angiopoietin-1 - physiology Animals Antigens, CD - biosynthesis Antigens, CD - genetics Biomedical and Life Sciences Biomedicine Blood-brain barrier Brain Ischemia - metabolism Cadherins - biosynthesis Cadherins - genetics Capillary Permeability - genetics Cell Biology Cerebral blood flow Disease Models, Animal Extravasation Gene Expression Regulation - genetics Humans Immunohistochemistry Ischemia Light chains Male Membrane permeability mRNA Myosin Nervous system Neurochemistry Neurology Neurosciences Occludin - biosynthesis Occludin - genetics Permeability Protein kinase C Protein Kinase C-alpha - biosynthesis Protein Kinase C-alpha - physiology Proteomics Random Allocation Rats Rats, Wistar Recombinant Proteins - pharmacology Reperfusion Reperfusion Injury - metabolism Signal transduction Signal Transduction - genetics Tight junctions Up-Regulation - genetics Western blotting Zonula occludens-1 protein Zonula Occludens-1 Protein - biosynthesis Zonula Occludens-1 Protein - genetics
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