Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit
Vilsmeier-Haack reaction conditions were applied on some methyl ketone aryl phosphonicdihydrazones to yield some interesting bis-pyrazole derivatives containing a hydro-phosphoryl unit. Bis-{4-formyl-3-aryl-1H-pyrazol-1-yl}phosphine oxides (4a,b) were condensed with some nucleophiles such as aniline...
Gespeichert in:
| Veröffentlicht in: | European journal of chemistry 2011-03, Vol.2 (1), p.25-35 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 35 |
|---|---|
| container_issue | 1 |
| container_start_page | 25 |
| container_title | European journal of chemistry |
| container_volume | 2 |
| creator | Abdel-Aziz, Salah Abdel-Ghaffar Ali, Tarik El-Sayed El-Mahdy, Kamilia Mohamed Abdel-Karim, Somaia Mohamed |
| description | Vilsmeier-Haack reaction conditions were applied on some methyl ketone aryl phosphonicdihydrazones to yield some interesting bis-pyrazole derivatives containing a hydro-phosphoryl unit. Bis-{4-formyl-3-aryl-1H-pyrazol-1-yl}phosphine oxides (4a,b) were condensed with some nucleophiles such as aniline, phenacyltriphenylphosphonium bromide and 4-phenylthiosemicarbazide followed by treatment with thioglycolic acid, diethyl phosphite and/or acetic anhydride to yield a novel class of bis-pyrazoles containing sulfur and phosphorus derivatives. Most of the newly synthesized compounds were evaluated for their in vitro antimicrobial activities. |
| doi_str_mv | 10.5155/eurjchem.2.1.25-35.208 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_926907618</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>926907618</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1328-39f72259e5b82f0bffa478146a29f3fde828ab87712555b0690cb1995e6e663c3</originalsourceid><addsrcrecordid>eNo9kE9LxDAQxYMouKz7FSQ3T61NsmmSoyz-gwUP6jmk7cRmaZuatAv10xtZdeAxc_jN8OYhdE2KnBPOb2EOh7qFPqc5ySnPGM9pIc_QihLOMkq5OP-ft-oSbWI8FKkYI0KIFfKvyzC1EF3EZmiSJte7OvjKmQ6benJHNzmI2FscfQ948EfocOViNi7BfPkOcAPBHU0iE1b7YTJucMMHNrhdmuDH1seksHR4Htx0hS6s6SJsfvsavT_cv-2esv3L4_Pubp_VhFGZMWVFMq-AV5LaorLWbIUk29JQZZltQFJpKikEoZzzqihVUVdEKQ4llCWr2RrdnO6OwX_OECfdu1hD15kB_By1omlFlEQmsjyR6esYA1g9BtebsGhS6J-M9V_GmmqiKdeM65Qx-waokHTs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>926907618</pqid></control><display><type>article</type><title>Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit</title><source>Full-Text Journals in Chemistry (Open access)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Abdel-Aziz, Salah Abdel-Ghaffar ; Ali, Tarik El-Sayed ; El-Mahdy, Kamilia Mohamed ; Abdel-Karim, Somaia Mohamed</creator><creatorcontrib>Abdel-Aziz, Salah Abdel-Ghaffar ; Ali, Tarik El-Sayed ; El-Mahdy, Kamilia Mohamed ; Abdel-Karim, Somaia Mohamed</creatorcontrib><description>Vilsmeier-Haack reaction conditions were applied on some methyl ketone aryl phosphonicdihydrazones to yield some interesting bis-pyrazole derivatives containing a hydro-phosphoryl unit. Bis-{4-formyl-3-aryl-1H-pyrazol-1-yl}phosphine oxides (4a,b) were condensed with some nucleophiles such as aniline, phenacyltriphenylphosphonium bromide and 4-phenylthiosemicarbazide followed by treatment with thioglycolic acid, diethyl phosphite and/or acetic anhydride to yield a novel class of bis-pyrazoles containing sulfur and phosphorus derivatives. Most of the newly synthesized compounds were evaluated for their in vitro antimicrobial activities.</description><identifier>ISSN: 2153-2249</identifier><identifier>EISSN: 2153-2257</identifier><identifier>DOI: 10.5155/eurjchem.2.1.25-35.208</identifier><language>eng</language><ispartof>European journal of chemistry, 2011-03, Vol.2 (1), p.25-35</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1328-39f72259e5b82f0bffa478146a29f3fde828ab87712555b0690cb1995e6e663c3</citedby><cites>FETCH-LOGICAL-c1328-39f72259e5b82f0bffa478146a29f3fde828ab87712555b0690cb1995e6e663c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids></links><search><creatorcontrib>Abdel-Aziz, Salah Abdel-Ghaffar</creatorcontrib><creatorcontrib>Ali, Tarik El-Sayed</creatorcontrib><creatorcontrib>El-Mahdy, Kamilia Mohamed</creatorcontrib><creatorcontrib>Abdel-Karim, Somaia Mohamed</creatorcontrib><title>Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit</title><title>European journal of chemistry</title><description>Vilsmeier-Haack reaction conditions were applied on some methyl ketone aryl phosphonicdihydrazones to yield some interesting bis-pyrazole derivatives containing a hydro-phosphoryl unit. Bis-{4-formyl-3-aryl-1H-pyrazol-1-yl}phosphine oxides (4a,b) were condensed with some nucleophiles such as aniline, phenacyltriphenylphosphonium bromide and 4-phenylthiosemicarbazide followed by treatment with thioglycolic acid, diethyl phosphite and/or acetic anhydride to yield a novel class of bis-pyrazoles containing sulfur and phosphorus derivatives. Most of the newly synthesized compounds were evaluated for their in vitro antimicrobial activities.</description><issn>2153-2249</issn><issn>2153-2257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNo9kE9LxDAQxYMouKz7FSQ3T61NsmmSoyz-gwUP6jmk7cRmaZuatAv10xtZdeAxc_jN8OYhdE2KnBPOb2EOh7qFPqc5ySnPGM9pIc_QihLOMkq5OP-ft-oSbWI8FKkYI0KIFfKvyzC1EF3EZmiSJte7OvjKmQ6benJHNzmI2FscfQ948EfocOViNi7BfPkOcAPBHU0iE1b7YTJucMMHNrhdmuDH1seksHR4Htx0hS6s6SJsfvsavT_cv-2esv3L4_Pubp_VhFGZMWVFMq-AV5LaorLWbIUk29JQZZltQFJpKikEoZzzqihVUVdEKQ4llCWr2RrdnO6OwX_OECfdu1hD15kB_By1omlFlEQmsjyR6esYA1g9BtebsGhS6J-M9V_GmmqiKdeM65Qx-waokHTs</recordid><startdate>20110331</startdate><enddate>20110331</enddate><creator>Abdel-Aziz, Salah Abdel-Ghaffar</creator><creator>Ali, Tarik El-Sayed</creator><creator>El-Mahdy, Kamilia Mohamed</creator><creator>Abdel-Karim, Somaia Mohamed</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7QO</scope><scope>7T7</scope><scope>7UA</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H97</scope><scope>L.G</scope><scope>P64</scope></search><sort><creationdate>20110331</creationdate><title>Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit</title><author>Abdel-Aziz, Salah Abdel-Ghaffar ; Ali, Tarik El-Sayed ; El-Mahdy, Kamilia Mohamed ; Abdel-Karim, Somaia Mohamed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1328-39f72259e5b82f0bffa478146a29f3fde828ab87712555b0690cb1995e6e663c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdel-Aziz, Salah Abdel-Ghaffar</creatorcontrib><creatorcontrib>Ali, Tarik El-Sayed</creatorcontrib><creatorcontrib>El-Mahdy, Kamilia Mohamed</creatorcontrib><creatorcontrib>Abdel-Karim, Somaia Mohamed</creatorcontrib><collection>CrossRef</collection><collection>Aqualine</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Water Resources Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>European journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdel-Aziz, Salah Abdel-Ghaffar</au><au>Ali, Tarik El-Sayed</au><au>El-Mahdy, Kamilia Mohamed</au><au>Abdel-Karim, Somaia Mohamed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit</atitle><jtitle>European journal of chemistry</jtitle><date>2011-03-31</date><risdate>2011</risdate><volume>2</volume><issue>1</issue><spage>25</spage><epage>35</epage><pages>25-35</pages><issn>2153-2249</issn><eissn>2153-2257</eissn><abstract>Vilsmeier-Haack reaction conditions were applied on some methyl ketone aryl phosphonicdihydrazones to yield some interesting bis-pyrazole derivatives containing a hydro-phosphoryl unit. Bis-{4-formyl-3-aryl-1H-pyrazol-1-yl}phosphine oxides (4a,b) were condensed with some nucleophiles such as aniline, phenacyltriphenylphosphonium bromide and 4-phenylthiosemicarbazide followed by treatment with thioglycolic acid, diethyl phosphite and/or acetic anhydride to yield a novel class of bis-pyrazoles containing sulfur and phosphorus derivatives. Most of the newly synthesized compounds were evaluated for their in vitro antimicrobial activities.</abstract><doi>10.5155/eurjchem.2.1.25-35.208</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2153-2249 |
| ispartof | European journal of chemistry, 2011-03, Vol.2 (1), p.25-35 |
| issn | 2153-2249 2153-2257 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_926907618 |
| source | Full-Text Journals in Chemistry (Open access); EZB-FREE-00999 freely available EZB journals |
| title | Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T00%3A07%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis%20and%20antimicrobial%20activities%20of%20some%20novel%20bis-pyrazole%20derivatives%20containing%20a%20hydrophosphoryl%20unit&rft.jtitle=European%20journal%20of%20chemistry&rft.au=Abdel-Aziz,%20Salah%20Abdel-Ghaffar&rft.date=2011-03-31&rft.volume=2&rft.issue=1&rft.spage=25&rft.epage=35&rft.pages=25-35&rft.issn=2153-2249&rft.eissn=2153-2257&rft_id=info:doi/10.5155/eurjchem.2.1.25-35.208&rft_dat=%3Cproquest_cross%3E926907618%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=926907618&rft_id=info:pmid/&rfr_iscdi=true |