Cloning and characterization of a novel tyrosine ammonia lyase-encoding gene involved in bagremycins biosynthesis in Streptomyces sp
Tyrosine ammonia lyase catalyzes the deamination of L-tyrosine to trans-coumaric acid. A novel tyrosine ammonia lyase-encoding gene, bagA, was cloned and sequenced from bagremycins-producing strain Streptomyces sp. Tü 4128 whose protein product contains a Ala–Ser–Gly segment in the active site. The...
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| Veröffentlicht in: | Biotechnology letters 2012-02, Vol.34 (2), p.269-274 |
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| creator | Zhu, Yunxia Liao, Siyi Ye, Jiang Zhang, Huizhan |
| description | Tyrosine ammonia lyase catalyzes the deamination of L-tyrosine to trans-coumaric acid. A novel tyrosine ammonia lyase-encoding gene, bagA, was cloned and sequenced from bagremycins-producing strain Streptomyces sp. Tü 4128 whose protein product contains a Ala–Ser–Gly segment in the active site. The disruption of the bagA gene abolished trans-coumaric acid and bagremycins production. trans-coumaric acid restored the formation of bagremycin A in the mutant, but not bagremycin B. Thus, trans-coumaric acid is a precursor for biosynthesis of bagremycins and the bagA gene codes for tyrosine ammonia lyase to synthesize trans-coumaric acid. This is a novel bacterial tal gene reported in actinomycetes for the second time and for the first time in a Streptomyces sp. |
| doi_str_mv | 10.1007/s10529-011-0755-9 |
| format | Article |
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A novel tyrosine ammonia lyase-encoding gene, bagA, was cloned and sequenced from bagremycins-producing strain Streptomyces sp. Tü 4128 whose protein product contains a Ala–Ser–Gly segment in the active site. The disruption of the bagA gene abolished trans-coumaric acid and bagremycins production. trans-coumaric acid restored the formation of bagremycin A in the mutant, but not bagremycin B. Thus, trans-coumaric acid is a precursor for biosynthesis of bagremycins and the bagA gene codes for tyrosine ammonia lyase to synthesize trans-coumaric acid. This is a novel bacterial tal gene reported in actinomycetes for the second time and for the first time in a Streptomyces sp.</description><identifier>ISSN: 0141-5492</identifier><identifier>EISSN: 1573-6776</identifier><identifier>DOI: 10.1007/s10529-011-0755-9</identifier><identifier>PMID: 22065278</identifier><identifier>CODEN: BILED3</identifier><language>eng</language><publisher>Dordrecht: Springer-Verlag</publisher><subject>Actinomycetes ; Amino Acid Sequence ; Amino acids ; Aminobenzoates - metabolism ; Ammonia ; Ammonia-Lyases - genetics ; Ammonia-Lyases - metabolism ; Applied Microbiology ; Bacteria ; Biochemistry ; Biological and medical sciences ; Biomedical and Life Sciences ; Biosynthesis ; Biotechnology ; Cloning ; Cloning, Molecular ; Coumaric Acids - metabolism ; DNA, Bacterial - chemistry ; DNA, Bacterial - genetics ; Fundamental and applied biological sciences. Psychology ; Gene Deletion ; Genes ; Life Sciences ; Microbiology ; Molecular Sequence Data ; Original Research Paper ; Proteins ; Segments ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid ; Streptomyces ; Tyrosine ; Tyrosine - metabolism</subject><ispartof>Biotechnology letters, 2012-02, Vol.34 (2), p.269-274</ispartof><rights>Springer Science+Business Media B.V. 2011</rights><rights>2015 INIST-CNRS</rights><rights>Springer Science+Business Media B.V. 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-ba3b10c27e2f69d20da3cb81f903ef451bc6400617e68be475aa5aa497b626c53</citedby><cites>FETCH-LOGICAL-c513t-ba3b10c27e2f69d20da3cb81f903ef451bc6400617e68be475aa5aa497b626c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10529-011-0755-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10529-011-0755-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25577303$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22065278$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Yunxia</creatorcontrib><creatorcontrib>Liao, Siyi</creatorcontrib><creatorcontrib>Ye, Jiang</creatorcontrib><creatorcontrib>Zhang, Huizhan</creatorcontrib><title>Cloning and characterization of a novel tyrosine ammonia lyase-encoding gene involved in bagremycins biosynthesis in Streptomyces sp</title><title>Biotechnology letters</title><addtitle>Biotechnol Lett</addtitle><addtitle>Biotechnol Lett</addtitle><description>Tyrosine ammonia lyase catalyzes the deamination of L-tyrosine to trans-coumaric acid. A novel tyrosine ammonia lyase-encoding gene, bagA, was cloned and sequenced from bagremycins-producing strain Streptomyces sp. Tü 4128 whose protein product contains a Ala–Ser–Gly segment in the active site. The disruption of the bagA gene abolished trans-coumaric acid and bagremycins production. trans-coumaric acid restored the formation of bagremycin A in the mutant, but not bagremycin B. Thus, trans-coumaric acid is a precursor for biosynthesis of bagremycins and the bagA gene codes for tyrosine ammonia lyase to synthesize trans-coumaric acid. This is a novel bacterial tal gene reported in actinomycetes for the second time and for the first time in a Streptomyces sp.</description><subject>Actinomycetes</subject><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Aminobenzoates - metabolism</subject><subject>Ammonia</subject><subject>Ammonia-Lyases - genetics</subject><subject>Ammonia-Lyases - metabolism</subject><subject>Applied Microbiology</subject><subject>Bacteria</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biosynthesis</subject><subject>Biotechnology</subject><subject>Cloning</subject><subject>Cloning, Molecular</subject><subject>Coumaric Acids - metabolism</subject><subject>DNA, Bacterial - chemistry</subject><subject>DNA, Bacterial - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Deletion</subject><subject>Genes</subject><subject>Life Sciences</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Original Research Paper</subject><subject>Proteins</subject><subject>Segments</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Amino Acid</subject><subject>Streptomyces</subject><subject>Tyrosine</subject><subject>Tyrosine - metabolism</subject><issn>0141-5492</issn><issn>1573-6776</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkl-L1DAUxYMo7rj6AXzRIIi-VG_SJmkeZfAfLPiw7nNJ09vZLG0yJp2B-uwHN6WjCz6MEEjg_M69Nzkh5DmDdwxAvU8MBNcFMFaAEqLQD8iGCVUWUin5kGyAVawQleYX5ElKdwCgFajH5IJzkIKrekN-bYfgnd9R4ztqb000dsLofprJBU9DTw314YgDneYYkvNIzThmh6HDbBIW6G3oFv8Os-b8MQxH7PKBtmYXcZyt84m2LqTZT7eYXFq06ynifgpZxUTT_il51Jsh4bPTfkluPn38vv1SXH37_HX74aqwgpVT0ZqyZWC5Qt5L3XHoTGnbmvUaSuwrwVorKwDJFMq6xUoJY_KqtGoll1aUl-TNWncfw48DpqkZXbI4DMZjOKRGc6lBKq7_T7JaqLqEKpNvz5JMKlZBqeTS_tU_6F04RJ9vnOupWnKhVIbYCtn83ili3-yjG02cGwbNknqzpt7k1Jsl9WaZ9sWp8KEdsfvr-BNzBl6fAJOsGfpovHXpnhNLZygzx1cuZcnvMN5PeK77y9XUm9Dk0HPhm2ue_17-b5XQnJ0luJI1K38DSefX9g</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Zhu, Yunxia</creator><creator>Liao, Siyi</creator><creator>Ye, Jiang</creator><creator>Zhang, Huizhan</creator><general>Springer-Verlag</general><general>Springer Netherlands</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7TB</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20120201</creationdate><title>Cloning and characterization of a novel tyrosine ammonia lyase-encoding gene involved in bagremycins biosynthesis in Streptomyces sp</title><author>Zhu, Yunxia ; Liao, Siyi ; Ye, Jiang ; Zhang, Huizhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-ba3b10c27e2f69d20da3cb81f903ef451bc6400617e68be475aa5aa497b626c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Actinomycetes</topic><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Aminobenzoates - metabolism</topic><topic>Ammonia</topic><topic>Ammonia-Lyases - genetics</topic><topic>Ammonia-Lyases - metabolism</topic><topic>Applied Microbiology</topic><topic>Bacteria</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biosynthesis</topic><topic>Biotechnology</topic><topic>Cloning</topic><topic>Cloning, Molecular</topic><topic>Coumaric Acids - metabolism</topic><topic>DNA, Bacterial - chemistry</topic><topic>DNA, Bacterial - genetics</topic><topic>Fundamental and applied biological sciences. 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A novel tyrosine ammonia lyase-encoding gene, bagA, was cloned and sequenced from bagremycins-producing strain Streptomyces sp. Tü 4128 whose protein product contains a Ala–Ser–Gly segment in the active site. The disruption of the bagA gene abolished trans-coumaric acid and bagremycins production. trans-coumaric acid restored the formation of bagremycin A in the mutant, but not bagremycin B. Thus, trans-coumaric acid is a precursor for biosynthesis of bagremycins and the bagA gene codes for tyrosine ammonia lyase to synthesize trans-coumaric acid. This is a novel bacterial tal gene reported in actinomycetes for the second time and for the first time in a Streptomyces sp.</abstract><cop>Dordrecht</cop><pub>Springer-Verlag</pub><pmid>22065278</pmid><doi>10.1007/s10529-011-0755-9</doi><tpages>6</tpages></addata></record> |
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| ispartof | Biotechnology letters, 2012-02, Vol.34 (2), p.269-274 |
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| subjects | Actinomycetes Amino Acid Sequence Amino acids Aminobenzoates - metabolism Ammonia Ammonia-Lyases - genetics Ammonia-Lyases - metabolism Applied Microbiology Bacteria Biochemistry Biological and medical sciences Biomedical and Life Sciences Biosynthesis Biotechnology Cloning Cloning, Molecular Coumaric Acids - metabolism DNA, Bacterial - chemistry DNA, Bacterial - genetics Fundamental and applied biological sciences. Psychology Gene Deletion Genes Life Sciences Microbiology Molecular Sequence Data Original Research Paper Proteins Segments Sequence Analysis, DNA Sequence Homology, Amino Acid Streptomyces Tyrosine Tyrosine - metabolism |
| title | Cloning and characterization of a novel tyrosine ammonia lyase-encoding gene involved in bagremycins biosynthesis in Streptomyces sp |
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