Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial

Summary Background After breast-conserving surgery, 90% of local recurrences occur within the index quadrant despite the presence of multicentric cancers elsewhere in the breast. Thus, restriction of radiation therapy to the tumour bed during surgery might be adequate for selected patients. We compa...

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Veröffentlicht in:The Lancet (British edition) 2010-07, Vol.376 (9735), p.91-102
Hauptverfasser: Vaidya, Jayant S, Dr, Joseph, David J, MD, Tobias, Jeffrey S, FRCR, Bulsara, Max, PhD, Wenz, Frederik, MD, Saunders, Christobel, FRCS, Alvarado, Michael, MD, Flyger, Henrik L, MD, Massarut, Samuele, MD, Eiermann, Wolfgang, MD, Keshtgar, Mohammed, PhD, Dewar, John, FRCR, Kraus-Tiefenbacher, Uta, MD, Sütterlin, Marc, MD, Esserman, Laura, MD, Holtveg, Helle MR, MD, Roncadin, Mario, MD, Pigorsch, Steffi, MD, Metaxas, Marinos, PhD, Falzon, Mary, FRCPath, Matthews, April, BSc, Corica, Tammy, PGDPH, Williams, Norman R, PhD, Baum, Michael, FRCS
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