Trastuzumab Has Opposing Effects on SN-38-induced Double-strand Breaks and Cytotoxicity in HER2-positive Gastric Cancer Cells Depending on Administration Sequence

We investigated the effects of trastuzumab, an anti-HER2 humanized monoclonal antibody, on DNA breaks induced by SN-38, a topoisomerase-1 inhibitor, in gastric cancer cell lines positive or negative for HER2 expression. NCI-N87 (HER2+) and MKN74 (HER2-) cells were exposed to SN-38 in the presence or...

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Veröffentlicht in:	Anticancer research 2012, Vol.32 (1), p.105-114
Hauptverfasser:	YAMADE, Mihoko, SUGIMOTO, Mitsushige, FURUTA, Takahisa, NISHINO, Masafumi, UOTANI, Takahiro, SAHARA, Shu, IWAIZUMI, Moriya, YAMADA, Takanori, OSAWA, Satoshi, SUGIMOTO, Ken, MIYAJIMA, Hiroaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal, Humanized - administration & dosage Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis - drug effects Biological and medical sciences Blotting, Western Camptothecin - administration & dosage Camptothecin - analogs & derivatives Cell Cycle - drug effects Cell Proliferation - drug effects DNA Breaks, Double-Stranded - drug effects Drug Administration Schedule Flow Cytometry Gastroenterology. Liver. Pancreas. Abdomen Humans Medical sciences Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism Receptor, ErbB-2 - metabolism Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Trastuzumab Tumor Cells, Cultured Tumors
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