Properties of Large-Conductance Cationic Channels in the Neuronal Nuclear Envelope
The genetic apparatus of the nucleus of eukaryotic cells is surrounded by the nuclear envelope containing ion channels with different biophysical properties. The channels responsible for calcium release from the nuclear envelope into the intranuclear space have attracted special attention. As we fou...
Gespeichert in:
| Veröffentlicht in: | Neurophysiology (New York) 2011-11, Vol.43 (3), p.192-194 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 194 |
|---|---|
| container_issue | 3 |
| container_start_page | 192 |
| container_title | Neurophysiology (New York) |
| container_volume | 43 |
| creator | Fedorenko, E. A. Semenova, O. V. Marchenko, S. M. |
| description | The genetic apparatus of the nucleus of eukaryotic cells is surrounded by the nuclear envelope containing ion channels with different biophysical properties. The channels responsible for calcium release from the nuclear envelope into the intranuclear space have attracted special attention. As we found, a great number of large-conductance ion channels selective with respect to monovalent cations and impermeable for bivalent cations are present in all membranes where inositol trisphosphate receptors are expressed. We showed that channels of this type are insensitive to blockers of potassium channels and, according to their properties, cannot be attributed to one well-known type of ion channels or another. In addition, since their blockers remain unknown, these channels at present cannot be isolated and cloned. Channels of this type deserve further investigation; we hypothesize that large-conductance cationic channels can be involved in the control of the duration of Ca
2+
release from the calcium store. |
| doi_str_mv | 10.1007/s11062-011-9202-8 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_926895699</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A358630986</galeid><sourcerecordid>A358630986</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-3c2de74ff60ce05c1f041d84065190027c6b04497fc3477c9b84e09c3d311f5b3</originalsourceid><addsrcrecordid>eNp1kVFrFDEUhYMouK7-AN-CL-JD6k0yM5k8lqHVwlKl6nPIZm62U2aTNcmI_nuzjCAVJJDAzXcO53IIec3hggOo95lz6AQDzpkWIFj_hGx4qyTT9fcp2QBoYEIr9Zy8yPkBALpetxty9znFE6YyYabR051NB2RDDOPiig0O6WDLFMPk6HBvQ8A50ynQco_0FpcUg53p7eJmtIlehR84V7OX5Jm3c8ZXf94t-XZ99XX4yHafPtwMlzvmGgGFSSdGVI33HTiE1nEPDR_7BrqW19BCuW4PTaOVd7JRyul93yBoJ0fJuW_3ckverr6nFL8vmIs5TtnhPNuAcclGi_OKndaVfPMP-RCXVLNXCNq-l1qKCl2s0MHOaKbgY0nW1TPicXIxoJ_q_FK2fSdB12tL3j0SVKbgz3KwS87m5svdY5avrEsx54TenNJ0tOmX4WDOBZq1QFMLNOcCTV81YtXkyoYDpr-p_y_6Dds8mxI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>905883932</pqid></control><display><type>article</type><title>Properties of Large-Conductance Cationic Channels in the Neuronal Nuclear Envelope</title><source>SpringerLink Journals - AutoHoldings</source><creator>Fedorenko, E. A. ; Semenova, O. V. ; Marchenko, S. M.</creator><creatorcontrib>Fedorenko, E. A. ; Semenova, O. V. ; Marchenko, S. M.</creatorcontrib><description>The genetic apparatus of the nucleus of eukaryotic cells is surrounded by the nuclear envelope containing ion channels with different biophysical properties. The channels responsible for calcium release from the nuclear envelope into the intranuclear space have attracted special attention. As we found, a great number of large-conductance ion channels selective with respect to monovalent cations and impermeable for bivalent cations are present in all membranes where inositol trisphosphate receptors are expressed. We showed that channels of this type are insensitive to blockers of potassium channels and, according to their properties, cannot be attributed to one well-known type of ion channels or another. In addition, since their blockers remain unknown, these channels at present cannot be isolated and cloned. Channels of this type deserve further investigation; we hypothesize that large-conductance cationic channels can be involved in the control of the duration of Ca
2+
release from the calcium store.</description><identifier>ISSN: 0090-2977</identifier><identifier>EISSN: 1573-9007</identifier><identifier>DOI: 10.1007/s11062-011-9202-8</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Analysis ; Biomedical and Life Sciences ; Biomedicine ; Calcium ; Calcium channels ; Cellular biology ; Inositol ; Inositol 1,4,5-trisphosphate receptors ; Ion channels ; Membranes ; Neurobiology ; Neurons ; Neurosciences ; Nuclear membranes ; Potassium channels</subject><ispartof>Neurophysiology (New York), 2011-11, Vol.43 (3), p.192-194</ispartof><rights>Springer Science+Business Media, Inc. 2011</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-3c2de74ff60ce05c1f041d84065190027c6b04497fc3477c9b84e09c3d311f5b3</citedby><cites>FETCH-LOGICAL-c420t-3c2de74ff60ce05c1f041d84065190027c6b04497fc3477c9b84e09c3d311f5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11062-011-9202-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11062-011-9202-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Fedorenko, E. A.</creatorcontrib><creatorcontrib>Semenova, O. V.</creatorcontrib><creatorcontrib>Marchenko, S. M.</creatorcontrib><title>Properties of Large-Conductance Cationic Channels in the Neuronal Nuclear Envelope</title><title>Neurophysiology (New York)</title><addtitle>Neurophysiology</addtitle><description>The genetic apparatus of the nucleus of eukaryotic cells is surrounded by the nuclear envelope containing ion channels with different biophysical properties. The channels responsible for calcium release from the nuclear envelope into the intranuclear space have attracted special attention. As we found, a great number of large-conductance ion channels selective with respect to monovalent cations and impermeable for bivalent cations are present in all membranes where inositol trisphosphate receptors are expressed. We showed that channels of this type are insensitive to blockers of potassium channels and, according to their properties, cannot be attributed to one well-known type of ion channels or another. In addition, since their blockers remain unknown, these channels at present cannot be isolated and cloned. Channels of this type deserve further investigation; we hypothesize that large-conductance cationic channels can be involved in the control of the duration of Ca
2+
release from the calcium store.</description><subject>Analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Calcium</subject><subject>Calcium channels</subject><subject>Cellular biology</subject><subject>Inositol</subject><subject>Inositol 1,4,5-trisphosphate receptors</subject><subject>Ion channels</subject><subject>Membranes</subject><subject>Neurobiology</subject><subject>Neurons</subject><subject>Neurosciences</subject><subject>Nuclear membranes</subject><subject>Potassium channels</subject><issn>0090-2977</issn><issn>1573-9007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kVFrFDEUhYMouK7-AN-CL-JD6k0yM5k8lqHVwlKl6nPIZm62U2aTNcmI_nuzjCAVJJDAzXcO53IIec3hggOo95lz6AQDzpkWIFj_hGx4qyTT9fcp2QBoYEIr9Zy8yPkBALpetxty9znFE6YyYabR051NB2RDDOPiig0O6WDLFMPk6HBvQ8A50ynQco_0FpcUg53p7eJmtIlehR84V7OX5Jm3c8ZXf94t-XZ99XX4yHafPtwMlzvmGgGFSSdGVI33HTiE1nEPDR_7BrqW19BCuW4PTaOVd7JRyul93yBoJ0fJuW_3ckverr6nFL8vmIs5TtnhPNuAcclGi_OKndaVfPMP-RCXVLNXCNq-l1qKCl2s0MHOaKbgY0nW1TPicXIxoJ_q_FK2fSdB12tL3j0SVKbgz3KwS87m5svdY5avrEsx54TenNJ0tOmX4WDOBZq1QFMLNOcCTV81YtXkyoYDpr-p_y_6Dds8mxI</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Fedorenko, E. A.</creator><creator>Semenova, O. V.</creator><creator>Marchenko, S. M.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M2M</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20111101</creationdate><title>Properties of Large-Conductance Cationic Channels in the Neuronal Nuclear Envelope</title><author>Fedorenko, E. A. ; Semenova, O. V. ; Marchenko, S. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-3c2de74ff60ce05c1f041d84065190027c6b04497fc3477c9b84e09c3d311f5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Analysis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Calcium</topic><topic>Calcium channels</topic><topic>Cellular biology</topic><topic>Inositol</topic><topic>Inositol 1,4,5-trisphosphate receptors</topic><topic>Ion channels</topic><topic>Membranes</topic><topic>Neurobiology</topic><topic>Neurons</topic><topic>Neurosciences</topic><topic>Nuclear membranes</topic><topic>Potassium channels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fedorenko, E. A.</creatorcontrib><creatorcontrib>Semenova, O. V.</creatorcontrib><creatorcontrib>Marchenko, S. M.</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Neurophysiology (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fedorenko, E. A.</au><au>Semenova, O. V.</au><au>Marchenko, S. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Properties of Large-Conductance Cationic Channels in the Neuronal Nuclear Envelope</atitle><jtitle>Neurophysiology (New York)</jtitle><stitle>Neurophysiology</stitle><date>2011-11-01</date><risdate>2011</risdate><volume>43</volume><issue>3</issue><spage>192</spage><epage>194</epage><pages>192-194</pages><issn>0090-2977</issn><eissn>1573-9007</eissn><abstract>The genetic apparatus of the nucleus of eukaryotic cells is surrounded by the nuclear envelope containing ion channels with different biophysical properties. The channels responsible for calcium release from the nuclear envelope into the intranuclear space have attracted special attention. As we found, a great number of large-conductance ion channels selective with respect to monovalent cations and impermeable for bivalent cations are present in all membranes where inositol trisphosphate receptors are expressed. We showed that channels of this type are insensitive to blockers of potassium channels and, according to their properties, cannot be attributed to one well-known type of ion channels or another. In addition, since their blockers remain unknown, these channels at present cannot be isolated and cloned. Channels of this type deserve further investigation; we hypothesize that large-conductance cationic channels can be involved in the control of the duration of Ca
2+
release from the calcium store.</abstract><cop>Boston</cop><pub>Springer US</pub><doi>10.1007/s11062-011-9202-8</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-2977 |
| ispartof | Neurophysiology (New York), 2011-11, Vol.43 (3), p.192-194 |
| issn | 0090-2977 1573-9007 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_926895699 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Analysis Biomedical and Life Sciences Biomedicine Calcium Calcium channels Cellular biology Inositol Inositol 1,4,5-trisphosphate receptors Ion channels Membranes Neurobiology Neurons Neurosciences Nuclear membranes Potassium channels |
| title | Properties of Large-Conductance Cationic Channels in the Neuronal Nuclear Envelope |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T00%3A29%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Properties%20of%20Large-Conductance%20Cationic%20Channels%20in%20the%20Neuronal%20Nuclear%20Envelope&rft.jtitle=Neurophysiology%20(New%20York)&rft.au=Fedorenko,%20E.%20A.&rft.date=2011-11-01&rft.volume=43&rft.issue=3&rft.spage=192&rft.epage=194&rft.pages=192-194&rft.issn=0090-2977&rft.eissn=1573-9007&rft_id=info:doi/10.1007/s11062-011-9202-8&rft_dat=%3Cgale_proqu%3EA358630986%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=905883932&rft_id=info:pmid/&rft_galeid=A358630986&rfr_iscdi=true |