Intermittent Hypobaric Hypoxia Preconditioning Induced Brain Ischemic Tolerance by Up-Regulating Glial Glutamate Transporter-1 in Rats
Several studies showed that the up-regulation of glial glutamate transporter-1 (GLT-1) participates in the acquisition of brain ischemic tolerance induced by cerebral ischemic preconditioning or ceftriaxone pretreatment in rats. To explore whether GLT-1 plays a role in the acquisition of brain ische...
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| Veröffentlicht in: | Neurochemical research 2012-03, Vol.37 (3), p.527-537 |
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| creator | Gong, Shu-Juan Chen, Ling-Yu Zhang, Min Gong, Jian-Xue Ma, Ya-Xian Zhang, Jian-Mei Wang, Yu-Jing Hu, Yu-Yan Sun, Xiao-Cai Li, Wen-Bin Zhang, Yi |
| description | Several studies showed that the up-regulation of glial glutamate transporter-1 (GLT-1) participates in the acquisition of brain ischemic tolerance induced by cerebral ischemic preconditioning or ceftriaxone pretreatment in rats. To explore whether GLT-1 plays a role in the acquisition of brain ischemic tolerance induced by intermittent hypobaric hypoxia (IH) preconditioning (mimicking 5,000 m high-altitude, 6 h per day, once daily for 28 days), immunohistochemistry and western blot were used to observe the changes in the expression of GLT-1 protein in hippocampal CA1 subfield during the induction of brain ischemic tolerance by IH preconditioning, and the effect of dihydrokainate (DHK), an inhibitor of GLT-1, on the acquisition of brain ischemic tolerance in rats. The basal expression of GLT-1 protein in hippocampal CA1 subfield was significantly up-regulated by IH preconditioning, and at the same time astrocytes were activated by IH preconditioning, which appeared normal soma and aplenty slender processes. The GLT-1 expression was decreased at 7 days after 8-min global brain ischemia. When the rats were pretreated with the IH preconditioning before the global brain ischemia, the down-regulation of GLT-1 protein was prevented clearly. Neuropathological evaluation by thionin staining showed that 200 nmol DHK blocked the protective role of IH preconditioning against delayed neuronal death induced normally by 8-min global brain ischemia. Taken together, the up-regulation of GLT-1 protein participates in the acquisition of brain ischemic tolerance induced by IH preconditioning in rats. |
| doi_str_mv | 10.1007/s11064-011-0639-3 |
| format | Article |
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To explore whether GLT-1 plays a role in the acquisition of brain ischemic tolerance induced by intermittent hypobaric hypoxia (IH) preconditioning (mimicking 5,000 m high-altitude, 6 h per day, once daily for 28 days), immunohistochemistry and western blot were used to observe the changes in the expression of GLT-1 protein in hippocampal CA1 subfield during the induction of brain ischemic tolerance by IH preconditioning, and the effect of dihydrokainate (DHK), an inhibitor of GLT-1, on the acquisition of brain ischemic tolerance in rats. The basal expression of GLT-1 protein in hippocampal CA1 subfield was significantly up-regulated by IH preconditioning, and at the same time astrocytes were activated by IH preconditioning, which appeared normal soma and aplenty slender processes. The GLT-1 expression was decreased at 7 days after 8-min global brain ischemia. When the rats were pretreated with the IH preconditioning before the global brain ischemia, the down-regulation of GLT-1 protein was prevented clearly. Neuropathological evaluation by thionin staining showed that 200 nmol DHK blocked the protective role of IH preconditioning against delayed neuronal death induced normally by 8-min global brain ischemia. Taken together, the up-regulation of GLT-1 protein participates in the acquisition of brain ischemic tolerance induced by IH preconditioning in rats.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-011-0639-3</identifier><identifier>PMID: 22076500</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Animals ; Astrocytes ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Blotting, Western ; Brain ; Brain Ischemia - metabolism ; Brain Ischemia - physiopathology ; Ceftriaxone ; Cell Biology ; excitatory amino acid transporter 2 ; Excitatory Amino Acid Transporter 2 - metabolism ; Hippocampus ; Hypoxia ; Hypoxia - physiopathology ; Immunohistochemistry ; Ischemia ; Ischemic Preconditioning ; Male ; Mimicry ; Neurochemistry ; Neurology ; Neurosciences ; Original Paper ; Rats ; Rats, Wistar ; Up-Regulation ; Western blotting</subject><ispartof>Neurochemical research, 2012-03, Vol.37 (3), p.527-537</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><rights>Springer Science+Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-3bfccd502f5fc84ff2cb544838970aee142b1c923db60151fe5013c365d0fd2b3</citedby><cites>FETCH-LOGICAL-c402t-3bfccd502f5fc84ff2cb544838970aee142b1c923db60151fe5013c365d0fd2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11064-011-0639-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11064-011-0639-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22076500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gong, Shu-Juan</creatorcontrib><creatorcontrib>Chen, Ling-Yu</creatorcontrib><creatorcontrib>Zhang, Min</creatorcontrib><creatorcontrib>Gong, Jian-Xue</creatorcontrib><creatorcontrib>Ma, Ya-Xian</creatorcontrib><creatorcontrib>Zhang, Jian-Mei</creatorcontrib><creatorcontrib>Wang, Yu-Jing</creatorcontrib><creatorcontrib>Hu, Yu-Yan</creatorcontrib><creatorcontrib>Sun, Xiao-Cai</creatorcontrib><creatorcontrib>Li, Wen-Bin</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><title>Intermittent Hypobaric Hypoxia Preconditioning Induced Brain Ischemic Tolerance by Up-Regulating Glial Glutamate Transporter-1 in Rats</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><addtitle>Neurochem Res</addtitle><description>Several studies showed that the up-regulation of glial glutamate transporter-1 (GLT-1) participates in the acquisition of brain ischemic tolerance induced by cerebral ischemic preconditioning or ceftriaxone pretreatment in rats. To explore whether GLT-1 plays a role in the acquisition of brain ischemic tolerance induced by intermittent hypobaric hypoxia (IH) preconditioning (mimicking 5,000 m high-altitude, 6 h per day, once daily for 28 days), immunohistochemistry and western blot were used to observe the changes in the expression of GLT-1 protein in hippocampal CA1 subfield during the induction of brain ischemic tolerance by IH preconditioning, and the effect of dihydrokainate (DHK), an inhibitor of GLT-1, on the acquisition of brain ischemic tolerance in rats. The basal expression of GLT-1 protein in hippocampal CA1 subfield was significantly up-regulated by IH preconditioning, and at the same time astrocytes were activated by IH preconditioning, which appeared normal soma and aplenty slender processes. The GLT-1 expression was decreased at 7 days after 8-min global brain ischemia. When the rats were pretreated with the IH preconditioning before the global brain ischemia, the down-regulation of GLT-1 protein was prevented clearly. Neuropathological evaluation by thionin staining showed that 200 nmol DHK blocked the protective role of IH preconditioning against delayed neuronal death induced normally by 8-min global brain ischemia. Taken together, the up-regulation of GLT-1 protein participates in the acquisition of brain ischemic tolerance induced by IH preconditioning in rats.</description><subject>Animals</subject><subject>Astrocytes</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blotting, Western</subject><subject>Brain</subject><subject>Brain Ischemia - metabolism</subject><subject>Brain Ischemia - physiopathology</subject><subject>Ceftriaxone</subject><subject>Cell Biology</subject><subject>excitatory amino acid transporter 2</subject><subject>Excitatory Amino Acid Transporter 2 - metabolism</subject><subject>Hippocampus</subject><subject>Hypoxia</subject><subject>Hypoxia - physiopathology</subject><subject>Immunohistochemistry</subject><subject>Ischemia</subject><subject>Ischemic Preconditioning</subject><subject>Male</subject><subject>Mimicry</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Up-Regulation</subject><subject>Western blotting</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkcFu1DAQhi1ERZfCA3BBERdOpjN2nGyOUEG7UqWianuOHGeyuErsYDtS9wV4brxsAQkJqRfb0nz_PzP-GXuD8AEB6vOICFXJAZFDJRsun7EVqlryqgH5nK1A5qrEBk7ZyxjvAbJK4At2KgTUlQJYsR8blyhMNiVyqbjaz77TwZpfrweri6-BjHe9TdY763bFxvWLob74FLR1xSaabzRlfOtHCtoZKrp9cTfzW9oto04HxeVo9ZjPJelJJyq2mYuzD7ktxyKb3OoUX7GTQY-RXj_eZ-zuy-ftxRW_vrncXHy85qYEkbjsBmN6BWJQg1mXwyBMp8pyLddNDZoIS9GhaYTsuwpQ4UAKUBpZqR6GXnTyjL0_-s7Bf18opnay0dA4akd-iW0jqnVT5i97AinqSopGZfLdP-S9X4LLa2QID8OpKkN4hEzwMQYa2jnYSYd9i9AewmyPYbY5zPYQZiuz5u2j8dJN1P9R_E4vA-IIxFxyOwp_O__f9Sf7B6rG</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Gong, Shu-Juan</creator><creator>Chen, Ling-Yu</creator><creator>Zhang, Min</creator><creator>Gong, Jian-Xue</creator><creator>Ma, Ya-Xian</creator><creator>Zhang, Jian-Mei</creator><creator>Wang, Yu-Jing</creator><creator>Hu, Yu-Yan</creator><creator>Sun, Xiao-Cai</creator><creator>Li, Wen-Bin</creator><creator>Zhang, Yi</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Intermittent Hypobaric Hypoxia Preconditioning Induced Brain Ischemic Tolerance by Up-Regulating Glial Glutamate Transporter-1 in Rats</title><author>Gong, Shu-Juan ; Chen, Ling-Yu ; Zhang, Min ; Gong, Jian-Xue ; Ma, Ya-Xian ; Zhang, Jian-Mei ; Wang, Yu-Jing ; Hu, Yu-Yan ; Sun, Xiao-Cai ; Li, Wen-Bin ; Zhang, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-3bfccd502f5fc84ff2cb544838970aee142b1c923db60151fe5013c365d0fd2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Astrocytes</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blotting, Western</topic><topic>Brain</topic><topic>Brain Ischemia - metabolism</topic><topic>Brain Ischemia - physiopathology</topic><topic>Ceftriaxone</topic><topic>Cell Biology</topic><topic>excitatory amino acid transporter 2</topic><topic>Excitatory Amino Acid Transporter 2 - metabolism</topic><topic>Hippocampus</topic><topic>Hypoxia</topic><topic>Hypoxia - physiopathology</topic><topic>Immunohistochemistry</topic><topic>Ischemia</topic><topic>Ischemic Preconditioning</topic><topic>Male</topic><topic>Mimicry</topic><topic>Neurochemistry</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Original Paper</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Up-Regulation</topic><topic>Western blotting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gong, Shu-Juan</creatorcontrib><creatorcontrib>Chen, Ling-Yu</creatorcontrib><creatorcontrib>Zhang, Min</creatorcontrib><creatorcontrib>Gong, Jian-Xue</creatorcontrib><creatorcontrib>Ma, Ya-Xian</creatorcontrib><creatorcontrib>Zhang, Jian-Mei</creatorcontrib><creatorcontrib>Wang, Yu-Jing</creatorcontrib><creatorcontrib>Hu, Yu-Yan</creatorcontrib><creatorcontrib>Sun, Xiao-Cai</creatorcontrib><creatorcontrib>Li, Wen-Bin</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gong, Shu-Juan</au><au>Chen, Ling-Yu</au><au>Zhang, Min</au><au>Gong, Jian-Xue</au><au>Ma, Ya-Xian</au><au>Zhang, Jian-Mei</au><au>Wang, Yu-Jing</au><au>Hu, Yu-Yan</au><au>Sun, Xiao-Cai</au><au>Li, Wen-Bin</au><au>Zhang, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intermittent Hypobaric Hypoxia Preconditioning Induced Brain Ischemic Tolerance by Up-Regulating Glial Glutamate Transporter-1 in Rats</atitle><jtitle>Neurochemical research</jtitle><stitle>Neurochem Res</stitle><addtitle>Neurochem Res</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>37</volume><issue>3</issue><spage>527</spage><epage>537</epage><pages>527-537</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><abstract>Several studies showed that the up-regulation of glial glutamate transporter-1 (GLT-1) participates in the acquisition of brain ischemic tolerance induced by cerebral ischemic preconditioning or ceftriaxone pretreatment in rats. To explore whether GLT-1 plays a role in the acquisition of brain ischemic tolerance induced by intermittent hypobaric hypoxia (IH) preconditioning (mimicking 5,000 m high-altitude, 6 h per day, once daily for 28 days), immunohistochemistry and western blot were used to observe the changes in the expression of GLT-1 protein in hippocampal CA1 subfield during the induction of brain ischemic tolerance by IH preconditioning, and the effect of dihydrokainate (DHK), an inhibitor of GLT-1, on the acquisition of brain ischemic tolerance in rats. The basal expression of GLT-1 protein in hippocampal CA1 subfield was significantly up-regulated by IH preconditioning, and at the same time astrocytes were activated by IH preconditioning, which appeared normal soma and aplenty slender processes. The GLT-1 expression was decreased at 7 days after 8-min global brain ischemia. When the rats were pretreated with the IH preconditioning before the global brain ischemia, the down-regulation of GLT-1 protein was prevented clearly. Neuropathological evaluation by thionin staining showed that 200 nmol DHK blocked the protective role of IH preconditioning against delayed neuronal death induced normally by 8-min global brain ischemia. Taken together, the up-regulation of GLT-1 protein participates in the acquisition of brain ischemic tolerance induced by IH preconditioning in rats.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22076500</pmid><doi>10.1007/s11064-011-0639-3</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Astrocytes Biochemistry Biomedical and Life Sciences Biomedicine Blotting, Western Brain Brain Ischemia - metabolism Brain Ischemia - physiopathology Ceftriaxone Cell Biology excitatory amino acid transporter 2 Excitatory Amino Acid Transporter 2 - metabolism Hippocampus Hypoxia Hypoxia - physiopathology Immunohistochemistry Ischemia Ischemic Preconditioning Male Mimicry Neurochemistry Neurology Neurosciences Original Paper Rats Rats, Wistar Up-Regulation Western blotting |
| title | Intermittent Hypobaric Hypoxia Preconditioning Induced Brain Ischemic Tolerance by Up-Regulating Glial Glutamate Transporter-1 in Rats |
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