Expression of metallothionein in ameloblastoma. A regulatory molecule?
J Oral Pathol Med (2010) 40: 516–519 Background: Ameloblastoma is a benign odontogenic tumor, exhibiting local invasiveness and high rate of recurrence. Metallothionein is a protein associated with tumorigenesis, serving as prognostic factor in different neoplasms. We are interested in mechanisms u...
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| creator | Ribeiro, André Luis Ribeiro Nobre, Rafaela Moutinho Rocha, Gabriela Cristina Marçal Avertano de Souza Lobato, Isabella Haber de Melo Alves Junior, Sérgio Jaeger, Ruy Gastaldoni de Jesus Viana Pinheiro, João |
| description | J Oral Pathol Med (2010) 40: 516–519
Background: Ameloblastoma is a benign odontogenic tumor, exhibiting local invasiveness and high rate of recurrence. Metallothionein is a protein associated with tumorigenesis, serving as prognostic factor in different neoplasms. We are interested in mechanisms underlying ameloblastoma local invasiveness. Thus, we decided to analyze expression of metallothionein in this tumor.
Materials and methods: An immunohistochemical evaluation of metallothionein in ameloblastoma was carried out. As control, we assessed expression of the same molecule in calcifying cystic odontogenic tumor (CCOT), a non‐invasive odontogenic neoplasm with ameloblastomatous epithelium.
Results: We studied 12 cases of solid/multicystic ameloblastomas. Metallothionein was observed in all samples. This molecule was observed in columnar cells in the periphery and in central polyhedral cells. CCOT (four cases) also showed the presence of metallothionein. Morphometry of stained areas showed that expression of metallothionein in ameloblastoma was significantly higher compared to CCOT (P |
| doi_str_mv | 10.1111/j.1600-0714.2011.01025.x |
| format | Article |
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Background: Ameloblastoma is a benign odontogenic tumor, exhibiting local invasiveness and high rate of recurrence. Metallothionein is a protein associated with tumorigenesis, serving as prognostic factor in different neoplasms. We are interested in mechanisms underlying ameloblastoma local invasiveness. Thus, we decided to analyze expression of metallothionein in this tumor.
Materials and methods: An immunohistochemical evaluation of metallothionein in ameloblastoma was carried out. As control, we assessed expression of the same molecule in calcifying cystic odontogenic tumor (CCOT), a non‐invasive odontogenic neoplasm with ameloblastomatous epithelium.
Results: We studied 12 cases of solid/multicystic ameloblastomas. Metallothionein was observed in all samples. This molecule was observed in columnar cells in the periphery and in central polyhedral cells. CCOT (four cases) also showed the presence of metallothionein. Morphometry of stained areas showed that expression of metallothionein in ameloblastoma was significantly higher compared to CCOT (P < 0.0001).
Conclusions: This protein may have an impact on ameloblastoma behavior. Metallothionein would act as a zinc reservoir for important proteases related to ameloblastoma biology, such as MMPs. This protein could also display pro‐mitotic and anti‐apoptotic features in the tumor.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/j.1600-0714.2011.01025.x</identifier><identifier>PMID: 21371124</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>ameloblastoma ; Ameloblastoma - metabolism ; Benign ; Biological and medical sciences ; Case-Control Studies ; Dentistry ; Epithelium ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Gene Expression Regulation, Neoplastic ; Humans ; Invasiveness ; matrix metalloproteinases ; Medical sciences ; Metallothionein ; Metallothionein - biosynthesis ; Metallothionein - genetics ; Morphometry ; Neoplasm Invasiveness ; odontogenic tumor ; Odontogenic tumors ; Odontogenic Tumors - metabolism ; oral pathology ; Otorhinolaryngology. Stomatology ; Polyhedra ; Proteinase ; Skin Neoplasms - metabolism ; Tumorigenesis ; Tumors ; Zinc</subject><ispartof>Journal of oral pathology & medicine, 2011-07, Vol.40 (6), p.516-519</ispartof><rights>2011 John Wiley & Sons A/S</rights><rights>2015 INIST-CNRS</rights><rights>2011 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4195-533a14b2a1f92da5fe5a9dea2fa06649ccec83b4baa5dd296a0d63463a3123963</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0714.2011.01025.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0714.2011.01025.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24301638$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21371124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ribeiro, André Luis Ribeiro</creatorcontrib><creatorcontrib>Nobre, Rafaela Moutinho</creatorcontrib><creatorcontrib>Rocha, Gabriela Cristina Marçal Avertano</creatorcontrib><creatorcontrib>de Souza Lobato, Isabella Haber</creatorcontrib><creatorcontrib>de Melo Alves Junior, Sérgio</creatorcontrib><creatorcontrib>Jaeger, Ruy Gastaldoni</creatorcontrib><creatorcontrib>de Jesus Viana Pinheiro, João</creatorcontrib><title>Expression of metallothionein in ameloblastoma. A regulatory molecule?</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>J Oral Pathol Med (2010) 40: 516–519
Background: Ameloblastoma is a benign odontogenic tumor, exhibiting local invasiveness and high rate of recurrence. Metallothionein is a protein associated with tumorigenesis, serving as prognostic factor in different neoplasms. We are interested in mechanisms underlying ameloblastoma local invasiveness. Thus, we decided to analyze expression of metallothionein in this tumor.
Materials and methods: An immunohistochemical evaluation of metallothionein in ameloblastoma was carried out. As control, we assessed expression of the same molecule in calcifying cystic odontogenic tumor (CCOT), a non‐invasive odontogenic neoplasm with ameloblastomatous epithelium.
Results: We studied 12 cases of solid/multicystic ameloblastomas. Metallothionein was observed in all samples. This molecule was observed in columnar cells in the periphery and in central polyhedral cells. CCOT (four cases) also showed the presence of metallothionein. Morphometry of stained areas showed that expression of metallothionein in ameloblastoma was significantly higher compared to CCOT (P < 0.0001).
Conclusions: This protein may have an impact on ameloblastoma behavior. Metallothionein would act as a zinc reservoir for important proteases related to ameloblastoma biology, such as MMPs. This protein could also display pro‐mitotic and anti‐apoptotic features in the tumor.</description><subject>ameloblastoma</subject><subject>Ameloblastoma - metabolism</subject><subject>Benign</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Dentistry</subject><subject>Epithelium</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Invasiveness</subject><subject>matrix metalloproteinases</subject><subject>Medical sciences</subject><subject>Metallothionein</subject><subject>Metallothionein - biosynthesis</subject><subject>Metallothionein - genetics</subject><subject>Morphometry</subject><subject>Neoplasm Invasiveness</subject><subject>odontogenic tumor</subject><subject>Odontogenic tumors</subject><subject>Odontogenic Tumors - metabolism</subject><subject>oral pathology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Polyhedra</subject><subject>Proteinase</subject><subject>Skin Neoplasms - metabolism</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><subject>Zinc</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EotvCX0C5IE4JHn8lPiDUrtoCqlo-xdGaJBPI4qy3cSJ2_z0Ju2yPWJZsa57X0szDWAI8g2m9XmVgOE95DioTHCDjwIXOto_Y4lh4zBbccpUKDeKEnca44hxyqeApOxEgcwChFuzqcrvpKcY2rJPQJB0N6H0Yfk5vatfJtLEjH0qPcQgdZsl50tOP0eMQ-l3SBU_V6OntM_akQR_p-eE8Y9-uLr8u36U3d9fvl-c3aaXA6lRLiaBKgdBYUaNuSKOtCUWD3Bhlq4qqQpaqRNR1LaxBXhupjEQJQlojz9ir_b-bPtyPFAfXtbEi73FNYYzOClPYqcf8v2SRq8IqZWEiXxzIseyodpu-7bDfuX9DmoCXBwBjhb7pcV218YFTkoORxcS92XO_W0-7Yx24m6W5lZvduNmNm6W5v9Lc1n24-zjfpny6z7dxoO0xj_0vZ3KZa_f99tpdfNGF_vR56ZbyD6QRmFE</recordid><startdate>201107</startdate><enddate>201107</enddate><creator>Ribeiro, André Luis Ribeiro</creator><creator>Nobre, Rafaela Moutinho</creator><creator>Rocha, Gabriela Cristina Marçal Avertano</creator><creator>de Souza Lobato, Isabella Haber</creator><creator>de Melo Alves Junior, Sérgio</creator><creator>Jaeger, Ruy Gastaldoni</creator><creator>de Jesus Viana Pinheiro, João</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7QP</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>201107</creationdate><title>Expression of metallothionein in ameloblastoma. A regulatory molecule?</title><author>Ribeiro, André Luis Ribeiro ; Nobre, Rafaela Moutinho ; Rocha, Gabriela Cristina Marçal Avertano ; de Souza Lobato, Isabella Haber ; de Melo Alves Junior, Sérgio ; Jaeger, Ruy Gastaldoni ; de Jesus Viana Pinheiro, João</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4195-533a14b2a1f92da5fe5a9dea2fa06649ccec83b4baa5dd296a0d63463a3123963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>ameloblastoma</topic><topic>Ameloblastoma - metabolism</topic><topic>Benign</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Dentistry</topic><topic>Epithelium</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Invasiveness</topic><topic>matrix metalloproteinases</topic><topic>Medical sciences</topic><topic>Metallothionein</topic><topic>Metallothionein - biosynthesis</topic><topic>Metallothionein - genetics</topic><topic>Morphometry</topic><topic>Neoplasm Invasiveness</topic><topic>odontogenic tumor</topic><topic>Odontogenic tumors</topic><topic>Odontogenic Tumors - metabolism</topic><topic>oral pathology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Polyhedra</topic><topic>Proteinase</topic><topic>Skin Neoplasms - metabolism</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ribeiro, André Luis Ribeiro</creatorcontrib><creatorcontrib>Nobre, Rafaela Moutinho</creatorcontrib><creatorcontrib>Rocha, Gabriela Cristina Marçal Avertano</creatorcontrib><creatorcontrib>de Souza Lobato, Isabella Haber</creatorcontrib><creatorcontrib>de Melo Alves Junior, Sérgio</creatorcontrib><creatorcontrib>Jaeger, Ruy Gastaldoni</creatorcontrib><creatorcontrib>de Jesus Viana Pinheiro, João</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ribeiro, André Luis Ribeiro</au><au>Nobre, Rafaela Moutinho</au><au>Rocha, Gabriela Cristina Marçal Avertano</au><au>de Souza Lobato, Isabella Haber</au><au>de Melo Alves Junior, Sérgio</au><au>Jaeger, Ruy Gastaldoni</au><au>de Jesus Viana Pinheiro, João</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of metallothionein in ameloblastoma. A regulatory molecule?</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2011-07</date><risdate>2011</risdate><volume>40</volume><issue>6</issue><spage>516</spage><epage>519</epage><pages>516-519</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>J Oral Pathol Med (2010) 40: 516–519
Background: Ameloblastoma is a benign odontogenic tumor, exhibiting local invasiveness and high rate of recurrence. Metallothionein is a protein associated with tumorigenesis, serving as prognostic factor in different neoplasms. We are interested in mechanisms underlying ameloblastoma local invasiveness. Thus, we decided to analyze expression of metallothionein in this tumor.
Materials and methods: An immunohistochemical evaluation of metallothionein in ameloblastoma was carried out. As control, we assessed expression of the same molecule in calcifying cystic odontogenic tumor (CCOT), a non‐invasive odontogenic neoplasm with ameloblastomatous epithelium.
Results: We studied 12 cases of solid/multicystic ameloblastomas. Metallothionein was observed in all samples. This molecule was observed in columnar cells in the periphery and in central polyhedral cells. CCOT (four cases) also showed the presence of metallothionein. Morphometry of stained areas showed that expression of metallothionein in ameloblastoma was significantly higher compared to CCOT (P < 0.0001).
Conclusions: This protein may have an impact on ameloblastoma behavior. Metallothionein would act as a zinc reservoir for important proteases related to ameloblastoma biology, such as MMPs. This protein could also display pro‐mitotic and anti‐apoptotic features in the tumor.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21371124</pmid><doi>10.1111/j.1600-0714.2011.01025.x</doi><tpages>4</tpages></addata></record> |
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| subjects | ameloblastoma Ameloblastoma - metabolism Benign Biological and medical sciences Case-Control Studies Dentistry Epithelium Facial bones, jaws, teeth, parodontium: diseases, semeiology Gene Expression Regulation, Neoplastic Humans Invasiveness matrix metalloproteinases Medical sciences Metallothionein Metallothionein - biosynthesis Metallothionein - genetics Morphometry Neoplasm Invasiveness odontogenic tumor Odontogenic tumors Odontogenic Tumors - metabolism oral pathology Otorhinolaryngology. Stomatology Polyhedra Proteinase Skin Neoplasms - metabolism Tumorigenesis Tumors Zinc |
| title | Expression of metallothionein in ameloblastoma. A regulatory molecule? |
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