The ubiquitin proteasome system in neurodegenerative diseases: culprit, accomplice or victim?

A shared hallmark for many neurodegenerative disorders is the accumulation of toxic protein species which is assumed to be the cause for these diseases. Since the ubiquitin proteasome system (UPS) is the most important pathway for selective protein degradation it is likely that it is involved in the...

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Veröffentlicht in:	Progress in neurobiology 2012-02, Vol.96 (2), p.190-207
Hauptverfasser:	Dennissen, F J A, Kholod, N, van Leeuwen, F W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Humans Models, Molecular Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurodegenerative Diseases - physiopathology Proteasome Endopeptidase Complex - metabolism Protein Conformation Proteolysis Signal Transduction - physiology Ubiquitin - chemistry Ubiquitin - metabolism Ubiquitination
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