Expression of stromal-cell-derived factor-1 (SDF-1): a predictor of ischaemic stroke?
Background and purpose: Platelet stromal‐cell‐derived factor‐1 (SDF‐1) plays a pivotal role in angiogenesis and the regeneration of ischaemic tissue through the regulation of haematopoietic progenitor cells and is upregulated at the sites of vascular injury and platelet activation. Thus, SDF‐1 has...
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| Veröffentlicht in: | European journal of neurology 2012-03, Vol.19 (3), p.395-401 |
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| creator | Wurster, T. Stellos, K. Geisler, T. Seizer, P. Andia, M. E. Schuster, A. May, A. E. Melms, A. Gawaz, M. Bigalke, B. |
| description | Background and purpose: Platelet stromal‐cell‐derived factor‐1 (SDF‐1) plays a pivotal role in angiogenesis and the regeneration of ischaemic tissue through the regulation of haematopoietic progenitor cells and is upregulated at the sites of vascular injury and platelet activation. Thus, SDF‐1 has recently been discussed as a predictor in ischaemic diseases such as acute myocardial infarction. However, no clinical data pertinent to the investigation of the platelet SDF‐1 expression in patients with stroke are available.
Methods: We consecutively evaluated 196 patients who were admitted to the stroke unit with symptoms suspected for stroke. Surface expression of the platelet activation markers (P‐selectin and GPIb) and the expression of platelet‐bound SDF‐1 were determined by two‐colour whole blood flow cytometry.
Results: Patients with transient ischaemic attack (TIA) as well as with ischaemic stroke showed similar levels of SDF‐1 expression on hospital admission compared with patients with non‐ischaemic (NI) events and with 30 healthy controls (TIA (mean fluorescence intensity ± SD): 31.5 ± 18.2 vs. NI: 26.4 ± 15.7; P = 0.361; stroke: 28.7 ± 19.8 vs. NI; P = 0.943; control: 26.1 ± 11.3; P > 0.05 compared with all). Platelet SDF‐1 expression showed a trend with the severity of stroke according to National Institute of Health Stroke Scale score (r = 0.125; P = 0.085), but significantly correlated with the peak levels of C‐reactive protein (r = 0.218; P = 0.002) and with the levels of platelet activation (P‐selectin: r = 0.389; P = 0.001). Multifactorial analysis of covariance revealed a significant influence on platelet SDF‐1 expression by smoking (P = 0.019).
Conclusions: Platelet SDF‐1 surface expression did not show any significant difference in patients with TIA and ischaemic stroke compared with patients with NI events. Thus, single biomarker evaluation of platelet SDF‐1 surface expression is not helpful to predict ischaemic stroke. |
| doi_str_mv | 10.1111/j.1468-1331.2011.03527.x |
| format | Article |
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Methods: We consecutively evaluated 196 patients who were admitted to the stroke unit with symptoms suspected for stroke. Surface expression of the platelet activation markers (P‐selectin and GPIb) and the expression of platelet‐bound SDF‐1 were determined by two‐colour whole blood flow cytometry.
Results: Patients with transient ischaemic attack (TIA) as well as with ischaemic stroke showed similar levels of SDF‐1 expression on hospital admission compared with patients with non‐ischaemic (NI) events and with 30 healthy controls (TIA (mean fluorescence intensity ± SD): 31.5 ± 18.2 vs. NI: 26.4 ± 15.7; P = 0.361; stroke: 28.7 ± 19.8 vs. NI; P = 0.943; control: 26.1 ± 11.3; P > 0.05 compared with all). Platelet SDF‐1 expression showed a trend with the severity of stroke according to National Institute of Health Stroke Scale score (r = 0.125; P = 0.085), but significantly correlated with the peak levels of C‐reactive protein (r = 0.218; P = 0.002) and with the levels of platelet activation (P‐selectin: r = 0.389; P = 0.001). Multifactorial analysis of covariance revealed a significant influence on platelet SDF‐1 expression by smoking (P = 0.019).
Conclusions: Platelet SDF‐1 surface expression did not show any significant difference in patients with TIA and ischaemic stroke compared with patients with NI events. Thus, single biomarker evaluation of platelet SDF‐1 surface expression is not helpful to predict ischaemic stroke.</description><identifier>ISSN: 1351-5101</identifier><identifier>EISSN: 1468-1331</identifier><identifier>DOI: 10.1111/j.1468-1331.2011.03527.x</identifier><identifier>PMID: 21951424</identifier><identifier>CODEN: EJNEFL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Aged, 80 and over ; Angiogenesis ; biomarkers ; Biomarkers - blood ; Blood Platelets - metabolism ; C-reactive protein ; Chemokine CXCL12 - analysis ; Chemokine CXCL12 - blood ; Data processing ; Female ; Flow Cytometry ; Fluorescence ; Hospitals ; Humans ; Injuries ; Ischemic Attack, Transient - blood ; Ischemic Attack, Transient - diagnosis ; Male ; Myocardial infarction ; P-selectin ; Platelets ; Regeneration ; SDF-1 ; SDF-1 protein ; Smoking ; Stem cells ; Stroke ; Stroke - blood ; Stroke - diagnosis ; TIA ; Transient ischemic attack</subject><ispartof>European journal of neurology, 2012-03, Vol.19 (3), p.395-401</ispartof><rights>2011 The Author(s). European Journal of Neurology © 2011 EFNS</rights><rights>2011 The Author(s). European Journal of Neurology © 2011 EFNS.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4667-2ba0950077195e299c601a49c9fcd7fc3e39c83f82332826123f5e9fb2a4107a3</citedby><cites>FETCH-LOGICAL-c4667-2ba0950077195e299c601a49c9fcd7fc3e39c83f82332826123f5e9fb2a4107a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1468-1331.2011.03527.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1468-1331.2011.03527.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21951424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wurster, T.</creatorcontrib><creatorcontrib>Stellos, K.</creatorcontrib><creatorcontrib>Geisler, T.</creatorcontrib><creatorcontrib>Seizer, P.</creatorcontrib><creatorcontrib>Andia, M. E.</creatorcontrib><creatorcontrib>Schuster, A.</creatorcontrib><creatorcontrib>May, A. E.</creatorcontrib><creatorcontrib>Melms, A.</creatorcontrib><creatorcontrib>Gawaz, M.</creatorcontrib><creatorcontrib>Bigalke, B.</creatorcontrib><title>Expression of stromal-cell-derived factor-1 (SDF-1): a predictor of ischaemic stroke?</title><title>European journal of neurology</title><addtitle>Eur J Neurol</addtitle><description>Background and purpose: Platelet stromal‐cell‐derived factor‐1 (SDF‐1) plays a pivotal role in angiogenesis and the regeneration of ischaemic tissue through the regulation of haematopoietic progenitor cells and is upregulated at the sites of vascular injury and platelet activation. Thus, SDF‐1 has recently been discussed as a predictor in ischaemic diseases such as acute myocardial infarction. However, no clinical data pertinent to the investigation of the platelet SDF‐1 expression in patients with stroke are available.
Methods: We consecutively evaluated 196 patients who were admitted to the stroke unit with symptoms suspected for stroke. Surface expression of the platelet activation markers (P‐selectin and GPIb) and the expression of platelet‐bound SDF‐1 were determined by two‐colour whole blood flow cytometry.
Results: Patients with transient ischaemic attack (TIA) as well as with ischaemic stroke showed similar levels of SDF‐1 expression on hospital admission compared with patients with non‐ischaemic (NI) events and with 30 healthy controls (TIA (mean fluorescence intensity ± SD): 31.5 ± 18.2 vs. NI: 26.4 ± 15.7; P = 0.361; stroke: 28.7 ± 19.8 vs. NI; P = 0.943; control: 26.1 ± 11.3; P > 0.05 compared with all). Platelet SDF‐1 expression showed a trend with the severity of stroke according to National Institute of Health Stroke Scale score (r = 0.125; P = 0.085), but significantly correlated with the peak levels of C‐reactive protein (r = 0.218; P = 0.002) and with the levels of platelet activation (P‐selectin: r = 0.389; P = 0.001). Multifactorial analysis of covariance revealed a significant influence on platelet SDF‐1 expression by smoking (P = 0.019).
Conclusions: Platelet SDF‐1 surface expression did not show any significant difference in patients with TIA and ischaemic stroke compared with patients with NI events. Thus, single biomarker evaluation of platelet SDF‐1 surface expression is not helpful to predict ischaemic stroke.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angiogenesis</subject><subject>biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood Platelets - metabolism</subject><subject>C-reactive protein</subject><subject>Chemokine CXCL12 - analysis</subject><subject>Chemokine CXCL12 - blood</subject><subject>Data processing</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Fluorescence</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Injuries</subject><subject>Ischemic Attack, Transient - blood</subject><subject>Ischemic Attack, Transient - diagnosis</subject><subject>Male</subject><subject>Myocardial infarction</subject><subject>P-selectin</subject><subject>Platelets</subject><subject>Regeneration</subject><subject>SDF-1</subject><subject>SDF-1 protein</subject><subject>Smoking</subject><subject>Stem cells</subject><subject>Stroke</subject><subject>Stroke - blood</subject><subject>Stroke - diagnosis</subject><subject>TIA</subject><subject>Transient ischemic attack</subject><issn>1351-5101</issn><issn>1468-1331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtPGzEURq2qVXm0fwGNxKJl4amvPX4hoaqCJK0UUQlKu7Qcjy0mzGRSO4Hw7_EQmkVXeOMr-5zra30IFUBKyOvLvIRKKAyMQUkJQEkYp7LcvEH7u4u3uWYcMAcCe-ggpTkhhEpK3qM9CppDRat9dDPaLKNPqekXRR-KtIp9Z1vsfNvi2sfm3tdFsG7VRwzF5-uLMYaT08IWWaqb4XiwmuRure8a9-zf-a8f0Ltg2-Q_vuyH6GY8-nX-HU9_Tn6cf5tiVwkhMZ1ZojkhUuZ5PNXaCQK20k4HV8vgmGfaKRYUZYwqKoCywL0OM2orINKyQ_Rp23cZ-79rn1amy7Pk2e3C9-tkNBVKUy71K0jgAoCoTB7_R877dVzkbxiQQihQirNMqS3lYp9S9MEsY9PZ-GiAmCEjMzdDFGaIwgwZmeeMzCarRy8PrGedr3fiv1AycLYFHprWP766sRldjoYq-3jrN2nlNzvfxjsjJJPc_LmcGBhPf19fVRNzxZ4AzOCrIQ</recordid><startdate>201203</startdate><enddate>201203</enddate><creator>Wurster, T.</creator><creator>Stellos, K.</creator><creator>Geisler, T.</creator><creator>Seizer, P.</creator><creator>Andia, M. E.</creator><creator>Schuster, A.</creator><creator>May, A. E.</creator><creator>Melms, A.</creator><creator>Gawaz, M.</creator><creator>Bigalke, B.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201203</creationdate><title>Expression of stromal-cell-derived factor-1 (SDF-1): a predictor of ischaemic stroke?</title><author>Wurster, T. ; Stellos, K. ; Geisler, T. ; Seizer, P. ; Andia, M. E. ; Schuster, A. ; May, A. E. ; Melms, A. ; Gawaz, M. ; Bigalke, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4667-2ba0950077195e299c601a49c9fcd7fc3e39c83f82332826123f5e9fb2a4107a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angiogenesis</topic><topic>biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood Platelets - metabolism</topic><topic>C-reactive protein</topic><topic>Chemokine CXCL12 - analysis</topic><topic>Chemokine CXCL12 - blood</topic><topic>Data processing</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Fluorescence</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Injuries</topic><topic>Ischemic Attack, Transient - blood</topic><topic>Ischemic Attack, Transient - diagnosis</topic><topic>Male</topic><topic>Myocardial infarction</topic><topic>P-selectin</topic><topic>Platelets</topic><topic>Regeneration</topic><topic>SDF-1</topic><topic>SDF-1 protein</topic><topic>Smoking</topic><topic>Stem cells</topic><topic>Stroke</topic><topic>Stroke - blood</topic><topic>Stroke - diagnosis</topic><topic>TIA</topic><topic>Transient ischemic attack</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wurster, T.</creatorcontrib><creatorcontrib>Stellos, K.</creatorcontrib><creatorcontrib>Geisler, T.</creatorcontrib><creatorcontrib>Seizer, P.</creatorcontrib><creatorcontrib>Andia, M. E.</creatorcontrib><creatorcontrib>Schuster, A.</creatorcontrib><creatorcontrib>May, A. E.</creatorcontrib><creatorcontrib>Melms, A.</creatorcontrib><creatorcontrib>Gawaz, M.</creatorcontrib><creatorcontrib>Bigalke, B.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wurster, T.</au><au>Stellos, K.</au><au>Geisler, T.</au><au>Seizer, P.</au><au>Andia, M. E.</au><au>Schuster, A.</au><au>May, A. E.</au><au>Melms, A.</au><au>Gawaz, M.</au><au>Bigalke, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of stromal-cell-derived factor-1 (SDF-1): a predictor of ischaemic stroke?</atitle><jtitle>European journal of neurology</jtitle><addtitle>Eur J Neurol</addtitle><date>2012-03</date><risdate>2012</risdate><volume>19</volume><issue>3</issue><spage>395</spage><epage>401</epage><pages>395-401</pages><issn>1351-5101</issn><eissn>1468-1331</eissn><coden>EJNEFL</coden><abstract>Background and purpose: Platelet stromal‐cell‐derived factor‐1 (SDF‐1) plays a pivotal role in angiogenesis and the regeneration of ischaemic tissue through the regulation of haematopoietic progenitor cells and is upregulated at the sites of vascular injury and platelet activation. Thus, SDF‐1 has recently been discussed as a predictor in ischaemic diseases such as acute myocardial infarction. However, no clinical data pertinent to the investigation of the platelet SDF‐1 expression in patients with stroke are available.
Methods: We consecutively evaluated 196 patients who were admitted to the stroke unit with symptoms suspected for stroke. Surface expression of the platelet activation markers (P‐selectin and GPIb) and the expression of platelet‐bound SDF‐1 were determined by two‐colour whole blood flow cytometry.
Results: Patients with transient ischaemic attack (TIA) as well as with ischaemic stroke showed similar levels of SDF‐1 expression on hospital admission compared with patients with non‐ischaemic (NI) events and with 30 healthy controls (TIA (mean fluorescence intensity ± SD): 31.5 ± 18.2 vs. NI: 26.4 ± 15.7; P = 0.361; stroke: 28.7 ± 19.8 vs. NI; P = 0.943; control: 26.1 ± 11.3; P > 0.05 compared with all). Platelet SDF‐1 expression showed a trend with the severity of stroke according to National Institute of Health Stroke Scale score (r = 0.125; P = 0.085), but significantly correlated with the peak levels of C‐reactive protein (r = 0.218; P = 0.002) and with the levels of platelet activation (P‐selectin: r = 0.389; P = 0.001). Multifactorial analysis of covariance revealed a significant influence on platelet SDF‐1 expression by smoking (P = 0.019).
Conclusions: Platelet SDF‐1 surface expression did not show any significant difference in patients with TIA and ischaemic stroke compared with patients with NI events. Thus, single biomarker evaluation of platelet SDF‐1 surface expression is not helpful to predict ischaemic stroke.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21951424</pmid><doi>10.1111/j.1468-1331.2011.03527.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Angiogenesis biomarkers Biomarkers - blood Blood Platelets - metabolism C-reactive protein Chemokine CXCL12 - analysis Chemokine CXCL12 - blood Data processing Female Flow Cytometry Fluorescence Hospitals Humans Injuries Ischemic Attack, Transient - blood Ischemic Attack, Transient - diagnosis Male Myocardial infarction P-selectin Platelets Regeneration SDF-1 SDF-1 protein Smoking Stem cells Stroke Stroke - blood Stroke - diagnosis TIA Transient ischemic attack |
| title | Expression of stromal-cell-derived factor-1 (SDF-1): a predictor of ischaemic stroke? |
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