Resveratrol Pretreatment Attenuates Cerebral Ischemic Injury by Upregulating Expression of Transcription Factor Nrf2 and HO-1 in Rats

Oxidative stress damage plays a vital role in cerebral ischemia/reperfusion (I/R) pathogenesis. The nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway can be activated by pharmacological and dietary means to attenuate cellular oxidative stress. Re...

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Veröffentlicht in:	Neurochemical research 2011-12, Vol.36 (12), p.2352-2362
Hauptverfasser:	Ren, Junwei, Fan, Cengceng, Chen, Na, Huang, Jiagui, Yang, Qin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - therapeutic use Biochemistry Biomedical and Life Sciences Biomedicine Brain Ischemia - drug therapy Brain Ischemia - metabolism Caspase 3 - biosynthesis Cell Biology DNA Fragmentation - drug effects Down-Regulation Heme Oxygenase-1 - biosynthesis Infarction, Middle Cerebral Artery - pathology Male Neurochemistry Neurology Neurosciences NF-E2-Related Factor 2 - biosynthesis Original Paper Oxidative Stress - drug effects Rats Rats, Sprague-Dawley Reperfusion Injury - pathology Reperfusion Injury - prevention & control Stilbenes - therapeutic use Up-Regulation - drug effects
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