High-Throughput Simultaneous Analysis of RNA, Protein, and Lipid Biomarkers in Heterogeneous Tissue Samples

With expanding biomarker discovery efforts and increasing costs of drug development, it is critical to maximize the value of mass-limited clinical samples. The main limitation of available methods is the inability to isolate and analyze, from a single sample, molecules requiring incompatible extract...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2011-11, Vol.57 (11), p.1545-1555
Hauptverfasser:	REISER, Vladimir, SMITH, Ryan C, TANEN, Michael R, LAZAR, Gloria, ZIEBA, Renata, ICHETOVKIN, Marina, ZHU CHEN, O'NEILL, Edward A, TANAKA, Wesley K, MARTON, Matthew J, JASON LIAO, MORRIS, Mark, JIYAN XUE, HAILMAN, Eric, TOKIWA, George Y, PLUMP, Andrew S, KURTZ, Marc M, RONG LIU, LEGRAND, Cheryl, XUANMIN HE, XIANG YU, PEGGY WONG, HINCHCLIFFE, John S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Biomarkers Biomarkers - analysis Cholesterol Cryopreservation Design Dissection Freezing Fundamental and applied biological sciences. Psychology Gene expression Humans Investigative techniques, diagnostic techniques (general aspects) Lipids - analysis Lipids - isolation & purification Medical instruments Medical sciences Methods Molecular biophysics Nitrogen Plaque, Atherosclerotic - chemistry Proteins - analysis Proteins - isolation & purification RNA - analysis RNA - isolation & purification RNA, Messenger - analysis RNA, Messenger - isolation & purification Shipments Specimen Handling - methods Tissue Extracts - chemistry Tissue Preservation - methods Tissues
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