Genotoxic effects of the cyanobacterial hepatotoxin cylindrospermopsin in the HepG2 cell line

The cyanobacterial alkaloid cylindrospermopsin (CYN) is being increasingly identified in drinking water supplies worldwide. It is a potent protein synthesis inhibitor and causes human intoxications and animal mortality. The few genotoxicity studies available indicate that CYN is genotoxic, generally...

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Veröffentlicht in:	Archives of toxicology 2011-12, Vol.85 (12), p.1617-1626
Hauptverfasser:	STRASER, Alja, FILIPIC, Metka, ZEGURA, Bojana
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimicrobial agents Bacterial Toxins Bacteriology Biological and medical sciences Biomedical and Life Sciences Biomedicine DNA Breaks - drug effects DNA damage DNA Damage - drug effects Dose-Response Relationship, Drug Environmental Health Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation - drug effects Genotoxicity and Carcinogenicity Health risk assessment Hep G2 Cells Humans Liver Medical sciences Microbiology Mutagenicity Tests Mutagens - administration & dosage Mutagens - toxicity Occupational Medicine/Industrial Medicine Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Pharmacology/Toxicology Polymerase Chain Reaction Time Factors Toxicity Toxicology Uracil - administration & dosage Uracil - analogs & derivatives Uracil - toxicity
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