Human monoclonal ScFv neutralize lethal Thai cobra, Naja kaouthia, neurotoxin

Animal derived anti-Naja. kaouthia (Thai cobra) venom is used for specific treatment of the snake bitten victims. Many recipients develop allergic reaction or anti-isotype response which causes serum sickness. A better therapeutic antibody is needed. In this study, long α-neurotoxin was purified fro...

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Veröffentlicht in:	Journal of proteomics 2009-03, Vol.72 (2), p.270-282
Hauptverfasser:	Kulkeaw, Kasem, Sakolvaree, Yuwaporn, Srimanote, Potjanee, Tongtawe, Pongsri, Maneewatch, Santi, Sookrung, Nitat, Tungtrongchitr, Anchalee, Tapchaisri, Pramuan, Kurazono, Hisao, Chaicumpa, Wanpen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors Amino Acid Sequence Animals Antibodies, Monoclonal - chemistry antibody libraries Base Sequence Blood donors Chromatography, Liquid - methods Elapid Venoms - analysis Elapid Venoms - chemistry Elapidae Epitopes Escherichia coli Hypersensitivity Immunoglobulin Fragments - analysis Immunoglobulin Fragments - chemistry Immunoglobulins Lethality Male Mice Mice, Inbred ICR Molecular Sequence Data Naja kaouthia Neurotoxins Neurotoxins - analysis Neurotoxins - chemistry Phage display proteomics Sequence Homology, Amino Acid Serum sickness Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Toxicity Venom
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