Phospho-Rb Mediating Cell Cycle Reentry Induces Early Apoptosis Following Oxygen–Glucose Deprivation in Rat Cortical Neurons

The aim of this study was to investigate the relationship between cell cycle reentry and apoptosis in cultured cortical neurons following oxygen–glucose deprivation (OGD). We found that the percentage of neurons with BrdU uptake, TUNEL staining, and colocalized BrdU uptake and TUNEL staining was inc...

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Veröffentlicht in:	Neurochemical research 2012-03, Vol.37 (3), p.503-511
Hauptverfasser:	Yu, Ying, Ren, Qing-Guo, Zhang, Zhao-Hui, Zhou, Ke, Yu, Zhi-Yuan, Luo, Xiang, Wang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - physiology Biochemistry Biomedical and Life Sciences Biomedicine Blotting, Western Cell Biology Cell cycle Cell Cycle - physiology Cerebral Cortex - cytology Cerebral Cortex - metabolism Cortex cyclin-dependent kinase inhibitors Flow Cytometry Glucose Glucose - metabolism Hypoxia Immunohistochemistry In Situ Nick-End Labeling Ischemia Neurochemistry Neurology Neurons Neurons - cytology Neurons - metabolism Neuroprotection Neurosciences Original Paper Oxygen Oxygen - metabolism Phosphorylation Rats Retinoblastoma protein Retinoblastoma Protein - physiology roscovitine
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