Improvement in organic solvent tolerance by double disruptions of proV and marR genes in Escherichia coli

Aims: To investigate the involvement of osmoprotectant transporters in organic solvent tolerance in Escherichia coli and to construct an E. coli strain with high organic solvent tolerance. Methods and Results: The organic solvent tolerance of ΔbetT, ΔproV, ΔproP or ΔputP single‐gene knockout mutants...

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Veröffentlicht in:	Journal of applied microbiology 2012-03, Vol.112 (3), p.464-474
Hauptverfasser:	Doukyu, N, Ishikawa, K, Watanabe, R, Ogino, H
Format:	Artikel
Sprache:	eng
Schlagworte:	biocatalysts Biological and medical sciences Drug Resistance, Bacterial - genetics efflux pump Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Fundamental and applied biological sciences. Psychology Gene Knockout Techniques genes Genes, Bacterial hexane Hexanes - pharmacology knockout mutants Lipoproteins - metabolism marR Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Microbiology Mutation organic solvent tolerant osmoprotectant osmotolerance Periplasmic Binding Proteins - genetics ProU system proV Repressor Proteins - genetics solvents Solvents - pharmacology transporters
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