Influence of Prior Pneumococcal and Influenza Vaccination on Outcomes of Older Adults with Community-Acquired Pneumonia

OBJECTIVES: To determine whether prior pneumococcal and seasonal influenza vaccination improves outcomes in older adults hospitalized for community‐acquired pneumonia (CAP). DESIGN: Prospective, observational, multicenter study. SETTING: Five public hospitals providing universal free care to the who...

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Veröffentlicht in:Journal of the American Geriatrics Society (JAGS) 2011-09, Vol.59 (9), p.1711-1716
Hauptverfasser: Manzur, Adriana, Izquierdo, Conchita, Ruiz, Laura, Sousa, Dolores, Bayas, Jose-María, Celorrio, Jose-Miguel, Varona, Wenceslao, Nebot, Manel, Salleras, Lluis, Domínguez, Angela, Carratalà, Jordi
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container_end_page 1716
container_issue 9
container_start_page 1711
container_title Journal of the American Geriatrics Society (JAGS)
container_volume 59
creator Manzur, Adriana
Izquierdo, Conchita
Ruiz, Laura
Sousa, Dolores
Bayas, Jose-María
Celorrio, Jose-Miguel
Varona, Wenceslao
Nebot, Manel
Salleras, Lluis
Domínguez, Angela
Carratalà, Jordi
description OBJECTIVES: To determine whether prior pneumococcal and seasonal influenza vaccination improves outcomes in older adults hospitalized for community‐acquired pneumonia (CAP). DESIGN: Prospective, observational, multicenter study. SETTING: Five public hospitals providing universal free care to the whole population in three Spanish regions. PARTICIPANTS: Individuals aged 65 and older admitted to the hospital with CAP through the emergency department. MEASUREMENTS: Pneumococcal and influenza vaccination status. The primary study outcomes were intensive care unit (ICU) admission, length of hospital stay (LOS), and overall case‐fatality rate. Outcome variables of individuals vaccinated with both vaccines were compared with outcomes of those who were unvaccinated. RESULTS: Two hundred thirty‐eight individuals had received 23‐valent pneumococcal polysaccharide vaccine and seasonal influenza vaccination and were compared with 195 unvaccinated individuals. No differences were found with respect to combined antibiotic therapy between groups (38.0% vs 39.7%; P=.80). Similar percentages of vaccinated and unvaccinated individuals required ICU admission (7.2% vs 8.2%; P=.69). Mean LOS was significantly shorter in vaccinated individuals (9.9 vs 12.4 days; P=.04). Overall case‐fatality rates were similar in both groups (5.9% vs 5.1%; P=.73). After adjustment, LOS, risk of ICU admission, and overall case‐fatality rate were not associated with prior pneumococcal and seasonal influenza vaccination. CONCLUSION: The clinical outcomes of vaccinated older adults hospitalized with CAP were not better than those observed in unvaccinated individuals.
doi_str_mv 10.1111/j.1532-5415.2011.03541.x
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DESIGN: Prospective, observational, multicenter study. SETTING: Five public hospitals providing universal free care to the whole population in three Spanish regions. PARTICIPANTS: Individuals aged 65 and older admitted to the hospital with CAP through the emergency department. MEASUREMENTS: Pneumococcal and influenza vaccination status. The primary study outcomes were intensive care unit (ICU) admission, length of hospital stay (LOS), and overall case‐fatality rate. Outcome variables of individuals vaccinated with both vaccines were compared with outcomes of those who were unvaccinated. RESULTS: Two hundred thirty‐eight individuals had received 23‐valent pneumococcal polysaccharide vaccine and seasonal influenza vaccination and were compared with 195 unvaccinated individuals. No differences were found with respect to combined antibiotic therapy between groups (38.0% vs 39.7%; P=.80). Similar percentages of vaccinated and unvaccinated individuals required ICU admission (7.2% vs 8.2%; P=.69). Mean LOS was significantly shorter in vaccinated individuals (9.9 vs 12.4 days; P=.04). Overall case‐fatality rates were similar in both groups (5.9% vs 5.1%; P=.73). After adjustment, LOS, risk of ICU admission, and overall case‐fatality rate were not associated with prior pneumococcal and seasonal influenza vaccination. CONCLUSION: The clinical outcomes of vaccinated older adults hospitalized with CAP were not better than those observed in unvaccinated individuals.</description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/j.1532-5415.2011.03541.x</identifier><identifier>PMID: 21806565</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Aged ; Aged, 80 and over ; Antibiotics ; Biological and medical sciences ; Clinical outcomes ; Community-Acquired Infections - epidemiology ; community-acquired pneumonia ; emergency medical services ; Female ; General aspects ; Geriatrics ; Hospitalization ; Hospitals ; Human viral diseases ; Humans ; Immunization ; Infectious diseases ; Influenza ; influenza vaccination ; Influenza Vaccines ; Intensive care units ; Male ; Medical sciences ; Older people ; Outcome Assessment (Health Care) ; pneumococcal vaccination ; Pneumococcal Vaccines ; Pneumonia ; Pneumonia - epidemiology ; Polysaccharides ; Prevention and actions ; Prospective Studies ; Public health. 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DESIGN: Prospective, observational, multicenter study. SETTING: Five public hospitals providing universal free care to the whole population in three Spanish regions. PARTICIPANTS: Individuals aged 65 and older admitted to the hospital with CAP through the emergency department. MEASUREMENTS: Pneumococcal and influenza vaccination status. The primary study outcomes were intensive care unit (ICU) admission, length of hospital stay (LOS), and overall case‐fatality rate. Outcome variables of individuals vaccinated with both vaccines were compared with outcomes of those who were unvaccinated. RESULTS: Two hundred thirty‐eight individuals had received 23‐valent pneumococcal polysaccharide vaccine and seasonal influenza vaccination and were compared with 195 unvaccinated individuals. No differences were found with respect to combined antibiotic therapy between groups (38.0% vs 39.7%; P=.80). Similar percentages of vaccinated and unvaccinated individuals required ICU admission (7.2% vs 8.2%; P=.69). Mean LOS was significantly shorter in vaccinated individuals (9.9 vs 12.4 days; P=.04). Overall case‐fatality rates were similar in both groups (5.9% vs 5.1%; P=.73). After adjustment, LOS, risk of ICU admission, and overall case‐fatality rate were not associated with prior pneumococcal and seasonal influenza vaccination. 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Hygiene-occupational medicine</topic><topic>Residence Characteristics</topic><topic>Seasonal variations</topic><topic>Streptococcus pneumoniae</topic><topic>Sulfur dioxide</topic><topic>Vaccines</topic><topic>Viral diseases</topic><topic>Viral diseases of the respiratory system and ent viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manzur, Adriana</creatorcontrib><creatorcontrib>Izquierdo, Conchita</creatorcontrib><creatorcontrib>Ruiz, Laura</creatorcontrib><creatorcontrib>Sousa, Dolores</creatorcontrib><creatorcontrib>Bayas, Jose-María</creatorcontrib><creatorcontrib>Celorrio, Jose-Miguel</creatorcontrib><creatorcontrib>Varona, Wenceslao</creatorcontrib><creatorcontrib>Nebot, Manel</creatorcontrib><creatorcontrib>Salleras, Lluis</creatorcontrib><creatorcontrib>Domínguez, Angela</creatorcontrib><creatorcontrib>Carratalà, Jordi</creatorcontrib><creatorcontrib>Working Group for the Study of Prevention of Community‐Acquired Pneumonia in the Elderly</creatorcontrib><creatorcontrib>for the Working Group for the Study of Prevention of Community‐Acquired Pneumonia in the Elderly</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manzur, Adriana</au><au>Izquierdo, Conchita</au><au>Ruiz, Laura</au><au>Sousa, Dolores</au><au>Bayas, Jose-María</au><au>Celorrio, Jose-Miguel</au><au>Varona, Wenceslao</au><au>Nebot, Manel</au><au>Salleras, Lluis</au><au>Domínguez, Angela</au><au>Carratalà, Jordi</au><aucorp>Working Group for the Study of Prevention of Community‐Acquired Pneumonia in the Elderly</aucorp><aucorp>for the Working Group for the Study of Prevention of Community‐Acquired Pneumonia in the Elderly</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Prior Pneumococcal and Influenza Vaccination on Outcomes of Older Adults with Community-Acquired Pneumonia</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>2011-09</date><risdate>2011</risdate><volume>59</volume><issue>9</issue><spage>1711</spage><epage>1716</epage><pages>1711-1716</pages><issn>0002-8614</issn><eissn>1532-5415</eissn><coden>JAGSAF</coden><abstract>OBJECTIVES: To determine whether prior pneumococcal and seasonal influenza vaccination improves outcomes in older adults hospitalized for community‐acquired pneumonia (CAP). DESIGN: Prospective, observational, multicenter study. SETTING: Five public hospitals providing universal free care to the whole population in three Spanish regions. PARTICIPANTS: Individuals aged 65 and older admitted to the hospital with CAP through the emergency department. MEASUREMENTS: Pneumococcal and influenza vaccination status. The primary study outcomes were intensive care unit (ICU) admission, length of hospital stay (LOS), and overall case‐fatality rate. Outcome variables of individuals vaccinated with both vaccines were compared with outcomes of those who were unvaccinated. RESULTS: Two hundred thirty‐eight individuals had received 23‐valent pneumococcal polysaccharide vaccine and seasonal influenza vaccination and were compared with 195 unvaccinated individuals. No differences were found with respect to combined antibiotic therapy between groups (38.0% vs 39.7%; P=.80). Similar percentages of vaccinated and unvaccinated individuals required ICU admission (7.2% vs 8.2%; P=.69). Mean LOS was significantly shorter in vaccinated individuals (9.9 vs 12.4 days; P=.04). Overall case‐fatality rates were similar in both groups (5.9% vs 5.1%; P=.73). After adjustment, LOS, risk of ICU admission, and overall case‐fatality rate were not associated with prior pneumococcal and seasonal influenza vaccination. CONCLUSION: The clinical outcomes of vaccinated older adults hospitalized with CAP were not better than those observed in unvaccinated individuals.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>21806565</pmid><doi>10.1111/j.1532-5415.2011.03541.x</doi><tpages>6</tpages></addata></record>
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subjects Aged
Aged, 80 and over
Antibiotics
Biological and medical sciences
Clinical outcomes
Community-Acquired Infections - epidemiology
community-acquired pneumonia
emergency medical services
Female
General aspects
Geriatrics
Hospitalization
Hospitals
Human viral diseases
Humans
Immunization
Infectious diseases
Influenza
influenza vaccination
Influenza Vaccines
Intensive care units
Male
Medical sciences
Older people
Outcome Assessment (Health Care)
pneumococcal vaccination
Pneumococcal Vaccines
Pneumonia
Pneumonia - epidemiology
Polysaccharides
Prevention and actions
Prospective Studies
Public health. Hygiene
Public health. Hygiene-occupational medicine
Residence Characteristics
Seasonal variations
Streptococcus pneumoniae
Sulfur dioxide
Vaccines
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
title Influence of Prior Pneumococcal and Influenza Vaccination on Outcomes of Older Adults with Community-Acquired Pneumonia
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