MicroRNA-23b promotes tolerogenic properties of dendritic cells in vitro through inhibiting Notch1/NF-κB signalling pathways

Background: MicroRNAs (miRNAs) are known to regulate the inflammatory response in various cell types. However, the ability of miRNAs to modulate dendritic cells (DCs) function for allergen immunotherapy is unclear. Objective: To assess the role of miR‐23b in the regulation of ovalbumin (OVA)‐induced...

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Veröffentlicht in:	Allergy (Copenhagen) 2012-03, Vol.67 (3), p.362-370
Hauptverfasser:	Zheng, J., Jiang, H.-Y., Li, J., Tang, H.-C., Zhang, X.-M., Wang, X.-R., Du, J.-T., Li, H.-B., Xu, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens Allergens - administration & dosage Allergens - immunology Allergic diseases Animals Biological and medical sciences Bone marrow Bone Marrow Cells - immunology CD4 antigen Cell Differentiation Cells, Cultured Dendritic cells Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - metabolism Dermatology Differentiation Foxp3 protein Fundamental and applied biological sciences. Psychology Fundamental immunology Gene expression Humans Hypersensitivity - immunology Hypersensitivity - therapy Immune Tolerance Immunoregulation Immunotherapy in vitro Inflammation Interleukin 10 Interleukin 12 Lymphocytes T Male Medical sciences Mice Mice, Inbred BALB C microRNAs MicroRNAs - immunology MicroRNAs - metabolism MicroRNAs - pharmacology miRNA Molecular modelling Monocytes NF- Kappa B protein NF-kappa B - antagonists & inhibitors NF-κB Notch Notch protein Osteoprogenitor cells Ovalbumin Ovalbumin - administration & dosage Ovalbumin - immunology Receptor, Notch1 - antagonists & inhibitors Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Signal transduction Signal Transduction - drug effects signalling pathway Surface markers T regulatory cells Transfection Up-Regulation
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