Aging impairs the control of prefrontal cortex on the release of corticosterone in response to stress and on memory consolidation

Abstract This study investigated the role of the dorsomedial prefrontal cortex (dmPFC) on the activity of the hypothalamus-pituitary-adrenal axis and memory consolidation in young and aged rats. The messenger RNA (mRNA) expression of several gamma-aminobutyric acid (GABA) and glutamate receptor subu...

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Veröffentlicht in:	Neurobiology of aging 2012-04, Vol.33 (4), p.827.e1-827.e9
Hauptverfasser:	Garrido, Pedro, De Blas, Marta, Giné, Elena, Santos, Ángel, Mora, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Analysis of Variance Animals Avoidance Learning - drug effects Corticosterone Corticosterone - blood GABA Antagonists - pharmacology GABA-A Receptor Agonists Inhibition (Psychology) Inhibitory avoidance Internal Medicine Male Memory - drug effects Memory - physiology Microinjection Microinjections - methods Muscimol Muscimol - pharmacology Neurology Picrotoxin Picrotoxin - pharmacology Prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - physiology Rat Rats Rats, Wistar Reaction Time - drug effects Restraint, Physical - methods Stress Time Factors
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