Functional genomics of trypanosomatids
Summary The decoding of the Tritryp reference genomes nearly 7 years ago provided a first peek into the biology of pathogenic trypanosomatids and a blueprint that has paved the way for genome‐wide studies. Although 60–70% of the predicted protein coding genes in Trypanosoma brucei, Trypanosoma cruzi...
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| Veröffentlicht in: | Parasite immunology 2012-02, Vol.34 (2-3), p.72-79 |
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| container_title | Parasite immunology |
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| creator | CHOI, J. EL-SAYED, N. M. |
| description | Summary
The decoding of the Tritryp reference genomes nearly 7 years ago provided a first peek into the biology of pathogenic trypanosomatids and a blueprint that has paved the way for genome‐wide studies. Although 60–70% of the predicted protein coding genes in Trypanosoma brucei, Trypanosoma cruzi and Leishmania major remain unannotated, the functional genomics landscape is rapidly changing. Facilitated by the advent of next‐generation sequencing technologies, improved structural and functional annotation and genes and their products are emerging. Information is also growing for the interactions between cellular components as transcriptomes, regulatory networks and metabolomes are characterized, ushering in a new era of systems biology. Simultaneously, the launch of comparative sequencing of multiple strains of kinetoplastids will finally lead to the investigation of a vast, yet to be explored, evolutionary and pathogenomic space. |
| doi_str_mv | 10.1111/j.1365-3024.2011.01347.x |
| format | Article |
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The decoding of the Tritryp reference genomes nearly 7 years ago provided a first peek into the biology of pathogenic trypanosomatids and a blueprint that has paved the way for genome‐wide studies. Although 60–70% of the predicted protein coding genes in Trypanosoma brucei, Trypanosoma cruzi and Leishmania major remain unannotated, the functional genomics landscape is rapidly changing. Facilitated by the advent of next‐generation sequencing technologies, improved structural and functional annotation and genes and their products are emerging. Information is also growing for the interactions between cellular components as transcriptomes, regulatory networks and metabolomes are characterized, ushering in a new era of systems biology. Simultaneously, the launch of comparative sequencing of multiple strains of kinetoplastids will finally lead to the investigation of a vast, yet to be explored, evolutionary and pathogenomic space.</description><subject>Animals</subject><subject>comparative</subject><subject>Genome, Protozoan - genetics</subject><subject>genomics</subject><subject>Genomics - methods</subject><subject>Humans</subject><subject>Leishmania major</subject><subject>metabolome</subject><subject>protein-protein interactions</subject><subject>Proteome</subject><subject>Protozoan Proteins - genetics</subject><subject>Protozoan Proteins - metabolism</subject><subject>Transcriptome</subject><subject>Trypanosoma brucei</subject><subject>Trypanosoma cruzi</subject><subject>trypanosomatids</subject><subject>Trypanosomatina - classification</subject><subject>Trypanosomatina - genetics</subject><subject>Trypanosomatina - metabolism</subject><issn>0141-9838</issn><issn>1365-3024</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMlOwzAUAC0EoqXwCygnOCV4d3zgABVpK5VFYpO4WG7ioJQsJU5E-_c4pPRcX_wkzzxLA4CHYIDcuVoGiHDmE4hpgCFCAUSEimB9AIa7h0MwhIgiX4YkHIATa5fQUZiTYzDA2E1CsiG4iNoybrKq1Ln3acqqyGLrVanX1JuVLitbFbrJEnsKjlKdW3O2vUfgNbp7GU_9-eNkNr6Z-zElofAXoeSJFBgaQYRIZCJJnFICRYK0EdogSDTHjGtCEwlRjMhChswwmnIOocZkBC77vau6-m6NbVSR2djkuS5N1VolMQ9DJtE-JKKYSSIdGfZkXFfW1iZVqzordL1RCKoup1qqrprqqqkup_rLqdZOPd9-0i4Kk-zE_34OuO6Bnyw3m70Xq6fZfTc53-_9zDZmvfN1_aW4S8jU-8NEfURv89vps1QR-QW-05BG</recordid><startdate>201202</startdate><enddate>201202</enddate><creator>CHOI, J.</creator><creator>EL-SAYED, N. M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope></search><sort><creationdate>201202</creationdate><title>Functional genomics of trypanosomatids</title><author>CHOI, J. ; EL-SAYED, N. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4387-b896d9720e7377d9d93cf4307d1ae7ae103a6256a34d901c13b985e54f6600a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>comparative</topic><topic>Genome, Protozoan - genetics</topic><topic>genomics</topic><topic>Genomics - methods</topic><topic>Humans</topic><topic>Leishmania major</topic><topic>metabolome</topic><topic>protein-protein interactions</topic><topic>Proteome</topic><topic>Protozoan Proteins - genetics</topic><topic>Protozoan Proteins - metabolism</topic><topic>Transcriptome</topic><topic>Trypanosoma brucei</topic><topic>Trypanosoma cruzi</topic><topic>trypanosomatids</topic><topic>Trypanosomatina - classification</topic><topic>Trypanosomatina - genetics</topic><topic>Trypanosomatina - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHOI, J.</creatorcontrib><creatorcontrib>EL-SAYED, N. 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M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional genomics of trypanosomatids</atitle><jtitle>Parasite immunology</jtitle><addtitle>Parasite Immunol</addtitle><date>2012-02</date><risdate>2012</risdate><volume>34</volume><issue>2-3</issue><spage>72</spage><epage>79</epage><pages>72-79</pages><issn>0141-9838</issn><eissn>1365-3024</eissn><abstract>Summary
The decoding of the Tritryp reference genomes nearly 7 years ago provided a first peek into the biology of pathogenic trypanosomatids and a blueprint that has paved the way for genome‐wide studies. Although 60–70% of the predicted protein coding genes in Trypanosoma brucei, Trypanosoma cruzi and Leishmania major remain unannotated, the functional genomics landscape is rapidly changing. Facilitated by the advent of next‐generation sequencing technologies, improved structural and functional annotation and genes and their products are emerging. Information is also growing for the interactions between cellular components as transcriptomes, regulatory networks and metabolomes are characterized, ushering in a new era of systems biology. Simultaneously, the launch of comparative sequencing of multiple strains of kinetoplastids will finally lead to the investigation of a vast, yet to be explored, evolutionary and pathogenomic space.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22132795</pmid><doi>10.1111/j.1365-3024.2011.01347.x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Parasite immunology, 2012-02, Vol.34 (2-3), p.72-79 |
| issn | 0141-9838 1365-3024 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Free Content; Access via Wiley Online Library; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals comparative Genome, Protozoan - genetics genomics Genomics - methods Humans Leishmania major metabolome protein-protein interactions Proteome Protozoan Proteins - genetics Protozoan Proteins - metabolism Transcriptome Trypanosoma brucei Trypanosoma cruzi trypanosomatids Trypanosomatina - classification Trypanosomatina - genetics Trypanosomatina - metabolism |
| title | Functional genomics of trypanosomatids |
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