Protection Against Protein Aggregation by Alpha-Crystallin as a Mechanism of Preconditioning

Anesthetic preconditioning occurs when cells previously exposed to inhaled anesthetics are protected against subsequent injury. We hypothesize that inhaled anesthetics may cause slight protein misfolding that involves site-specific dehydration, stimulating cytoprotective mechanisms. Human neuroblast...

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Veröffentlicht in:	Neurochemical research 2012-02, Vol.37 (2), p.244-252
Hauptverfasser:	Ferns, Jonathan E., Theisen, Christopher S., Fibuch, Eugene E., Seidler, Norbert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Crystallins - physiology Anesthetics, Inhalation - adverse effects Base Sequence Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cell Line, Tumor DNA Primers Electrophoresis, Polyacrylamide Gel Heat-Shock Proteins - metabolism Humans Neurochemistry Neurology Neurosciences Original Paper Real-Time Polymerase Chain Reaction
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