Caspase-4 is required for activation of inflammasomes

IL-1β and IL-18 are crucial regulators of inflammation and immunity. Both cytokines are initially expressed as inactive precursors, which require processing by the protease caspase-1 for biological activity. Caspase-1 itself is activated in different innate immune complexes called inflammasomes. In...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-02, Vol.188 (4), p.1992-2000
Hauptverfasser:	Sollberger, Gabriel, Strittmatter, Gerhard E, Kistowska, Magdalena, French, Lars E, Beer, Hans-Dietmar
Format:	Artikel
Sprache:	eng
Schlagworte:	Carrier Proteins - metabolism Caspase 1 - biosynthesis Caspase 1 - genetics Caspase 1 - immunology Caspase 1 - metabolism Caspases, Initiator - genetics Caspases, Initiator - immunology Caspases, Initiator - metabolism Cells, Cultured Cytoskeletal Proteins - metabolism Humans Inflammasomes - immunology Inflammasomes - metabolism Interleukin-18 - biosynthesis Interleukin-18 - immunology Interleukin-18 - metabolism Interleukin-1beta - biosynthesis Interleukin-1beta - immunology Interleukin-1beta - metabolism Keratinocytes - metabolism Macrophages - immunology Macrophages - metabolism NLR Family, Pyrin Domain-Containing 3 Protein Pyrin RNA Interference RNA, Small Interfering Ultraviolet Rays
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