Prime-boost regimens with adjuvanted synthetic long peptides elicit T cells and antibodies to conserved regions of HIV-1 in macaques

Administration of synthetic long peptides (SLPs) derived from human papillomavirus to cervical cancer patients resulted in clinical benefit correlated with expansions of tumour-specific T cells. Because vaginal mucosa is an important port of entry for HIV-1, we have explored SLP for HIV-1 vaccinatio...

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Veröffentlicht in:	AIDS (London) 2012-01, Vol.26 (3), p.275-284
Hauptverfasser:	ROSARIO, Maximillian, BORTHWICK, Nicola, DRIJFHOUT, Jan W, MELIEF, Cornelis J. M, HANKE, Tomas, STEWART-JONES, Guillaume B, MBEWE-MVULA, Alice, BRIDGEMAN, Anne, COLLOCA, Stefano, MONTEFIORI, David, MCMICHAEL, Andrew J, NICOSIA, Alfredo, QUAKKELAAR, Esther D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus Adjuvants, Immunologic - pharmacology AIDS Vaccines - immunology AIDS Vaccines - pharmacology AIDS/HIV Animals Biological and medical sciences Cell Proliferation - drug effects DNA, Viral - immunology Electroporation HIV Antibodies - immunology HIV-1 - drug effects Human immunodeficiency virus 1 Human viral diseases Immunization, Secondary - methods Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Lymphocyte Activation Macaca mulatta Medical sciences Pan troglodytes Vaccines, Synthetic - immunology Vaccines, Synthetic - pharmacology Vaccinia virus Vaccinia virus - immunology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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