Molecular pathology and genetic advances in amyotrophic lateral sclerosis: an emerging molecular pathway and the significance of glial pathology

Research into amyotrophic lateral sclerosis (ALS) has been stimulated by a series of genetic and molecular pathology discoveries. The hallmark neuronal cytoplasmic inclusions of sporadic ALS (sALS) predominantly comprise a nuclear RNA processing protein, TDP-43 encoded by the gene TARDBP , a discove...

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Veröffentlicht in:	Acta neuropathologica 2011-12, Vol.122 (6), p.657-671
Hauptverfasser:	Ince, Paul G., Highley, J. Robin, Kirby, Janine, Wharton, Stephen B., Takahashi, Hitoshi, Strong, Michael J., Shaw, Pamela J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Brain Dementia DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Frontotemporal dementia FUS gene Genes Genetics Humans Hypotheses Inclusion bodies Medicine Medicine & Public Health Motor neurone disease Motor systems Mutation Mutation - genetics Neurodegeneration Neuroglia - pathology Neuronal-glial interactions Neuropathology Neurosciences Pathogenesis Pathogenicity Pathology Pathology, Molecular - trends Proteins Review RNA processing RNA-Binding Protein FUS - genetics RNA-Binding Protein FUS - metabolism Sarcoma Signal Transduction - genetics Superoxide dismutase
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