A carrier fusion significantly induces unfolded protein response in heterologous protein production by Aspergillus oryzae

In heterologous protein production by filamentous fungi, target proteins are expressed as fusions with homologous secretory proteins, called carriers, for higher production yields. Although carrier fusion is thought to overcome the bottleneck in transcriptional and (post)translational processes duri...

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Veröffentlicht in:	Applied microbiology and biotechnology 2011-12, Vol.92 (6), p.1197-1206
Hauptverfasser:	Ohno, Ayako, Maruyama, Jun-ichi, Nemoto, Takashi, Arioka, Manabu, Kitamoto, Katsuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Applied Genetics and Molecular Biotechnology Aspergillus oryzae Aspergillus oryzae - genetics Aspergillus oryzae - metabolism Biological and medical sciences Biomedical and Life Sciences Biotechnology Cattle Chymosin - genetics Chymosin - metabolism Cloning Deoxyribonucleic acid DNA Endoplasmic reticulum Endoplasmic Reticulum - genetics Endoplasmic Reticulum - metabolism Fundamental and applied biological sciences. Psychology Fungi Gene Expression Gene Expression Regulation, Fungal Genetic engineering Genomes Life Sciences Microbial Genetics and Genomics Microbiology Peptides Physiology Plasmids Protein Transport Proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Studies Unfolded Protein Response
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