Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP4 receptor

J. Neurochem. (2012) 120, 795–805. Amyloid‐β peptide (Aβ), which is generated by the β‐ and γ‐secretase‐mediated proteolysis of β‐amyloid precursor protein (APP), plays an important role in the pathogenesis of Alzheimer’s disease (AD). We recently reported that prostaglandin E2 (PGE2) stimulates the...

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Veröffentlicht in:	Journal of neurochemistry 2012-03, Vol.120 (5), p.795-805
Hauptverfasser:	Hoshino, Tatsuya, Namba, Takushi, Takehara, Masaya, Murao, Naoya, Matsushima, Takahide, Sugimoto, Yukihiko, Narumiya, Shuh, Suzuki, Toshiharu, Mizushima, Tohru
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies aging Alzheimer disease Alzheimer's disease Amyloid precursor protein Animal cognition Animal models beta -Amyloid Biological and medical sciences Brain Cognitive ability Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Endocytosis infammation Medical sciences memory Neurochemistry neurodegeneration Neurodegenerative diseases Neurology Oral administration Organic mental disorders. Neuropsychology Plaques Prostaglandin E2 Proteins Proteolysis Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptor mechanisms Rodents Secretase Transgenic mice
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