The effect of curing light and chemical catalyst on the degree of conversion of two dual cured resin luting cements

The aim of this study was to evaluate the influence of different curing lights and chemical catalysts on the degree of conversion of resin luting cements. A total of 60 disk-shaped specimens of RelyX ARC or Panavia F of diameter 5 mm and thickness 0.5 mm were prepared and the respective chemical cat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Lasers in medical science 2012-01, Vol.27 (1), p.145-151
Hauptverfasser: Souza-Junior, Eduardo José, Prieto, Lúcia Trazzi, Soares, Giulliana Panfiglio, dos Santos Dias, Carlos Tadeu, Aguiar, Flávio Henrique Baggio, Paulillo, Luís Alexandre Maffei Sartini
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 151
container_issue 1
container_start_page 145
container_title Lasers in medical science
container_volume 27
creator Souza-Junior, Eduardo José
Prieto, Lúcia Trazzi
Soares, Giulliana Panfiglio
dos Santos Dias, Carlos Tadeu
Aguiar, Flávio Henrique Baggio
Paulillo, Luís Alexandre Maffei Sartini
description The aim of this study was to evaluate the influence of different curing lights and chemical catalysts on the degree of conversion of resin luting cements. A total of 60 disk-shaped specimens of RelyX ARC or Panavia F of diameter 5 mm and thickness 0.5 mm were prepared and the respective chemical catalyst (Scotchbond Multi-Purpose Plus or ED Primer) was added. The specimens were light-cured using different curing units (an argon ion laser, an LED or a quartz-tungsten-halogen light) through shade A2 composite disks of diameter 10 mm and thickness 2 mm. After 24 h of dry storage at 37°C, the degree of conversion of the resin luting cements was measured by Fourier-transformed infrared spectroscopy. For statistical analysis, ANOVA and the Tukey test were used, with p  ≤ 0.05. Panavia F when used without catalyst and cured using the LED or the argon ion laser showed degree of conversion values significantly lower than RelyX ARC, with and without catalyst, and cured with any of the light sources. Therefore, the degree of conversion of Panavia F with ED Primer cured with the quartz-tungsten-halogen light was significantly different from that of RelyX ARC regardless of the use of the chemical catalyst and light curing source. In conclusion, RelyX ARC can be cured satisfactorily with the argon ion laser, LED or quartz-tungsten-halogen light with or without a chemical catalyst. To obtain a satisfactory degree of conversion, Panavia F luting cement should be used with ED Primer and cured with halogen light.
doi_str_mv 10.1007/s10103-010-0857-y
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_926883171</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>915627164</sourcerecordid><originalsourceid>FETCH-LOGICAL-c468t-23e03828d5a63106608447afd21d4686affbcd99d0fd00ba94e3cba5a2b93ff3</originalsourceid><addsrcrecordid>eNqFkU2LFDEQhoMo7rj6A7xI8OKptSrpTqePsvgFC17m4C2kk8pML_0xJmll_r1pZ1UQxEuFkOd9K1UvY88RXiNA-yYhIMiqlAp001bnB2yHtWwqBfWXh2wHQulKdwKv2JOU7gCwVSgfsyuBCLXQasfS_kicQiCX-RK4W-MwH_g4HI6Z29lzd6RpcHbkzmY7nlOhZp6LxtMhEv3ULPM3imkoD-WWvy_cr5tgjeR5pDTMfFzzZutoojmnp-xRsGOiZ_fnNdu_f7e_-Vjdfv7w6ebtbeVqpXMlJIHUQvvGKomgFOi6bm3wAn0BlA2hd77rPAQP0NuuJul621jRdzIEec1eXWxPcfm6UspmGpKjcbQzLWsyXdmOltji_0lslGhR1YV8-Rd5t6xxLlNsEJQvqq5AeIFcXFKKFMwpDpONZ4NgtuDMJThTitmCM-eieXFvvPYT-d-KX0kVQFyAdNoiovin879dfwDmsaQk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>915060869</pqid></control><display><type>article</type><title>The effect of curing light and chemical catalyst on the degree of conversion of two dual cured resin luting cements</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Souza-Junior, Eduardo José ; Prieto, Lúcia Trazzi ; Soares, Giulliana Panfiglio ; dos Santos Dias, Carlos Tadeu ; Aguiar, Flávio Henrique Baggio ; Paulillo, Luís Alexandre Maffei Sartini</creator><creatorcontrib>Souza-Junior, Eduardo José ; Prieto, Lúcia Trazzi ; Soares, Giulliana Panfiglio ; dos Santos Dias, Carlos Tadeu ; Aguiar, Flávio Henrique Baggio ; Paulillo, Luís Alexandre Maffei Sartini</creatorcontrib><description>The aim of this study was to evaluate the influence of different curing lights and chemical catalysts on the degree of conversion of resin luting cements. A total of 60 disk-shaped specimens of RelyX ARC or Panavia F of diameter 5 mm and thickness 0.5 mm were prepared and the respective chemical catalyst (Scotchbond Multi-Purpose Plus or ED Primer) was added. The specimens were light-cured using different curing units (an argon ion laser, an LED or a quartz-tungsten-halogen light) through shade A2 composite disks of diameter 10 mm and thickness 2 mm. After 24 h of dry storage at 37°C, the degree of conversion of the resin luting cements was measured by Fourier-transformed infrared spectroscopy. For statistical analysis, ANOVA and the Tukey test were used, with p  ≤ 0.05. Panavia F when used without catalyst and cured using the LED or the argon ion laser showed degree of conversion values significantly lower than RelyX ARC, with and without catalyst, and cured with any of the light sources. Therefore, the degree of conversion of Panavia F with ED Primer cured with the quartz-tungsten-halogen light was significantly different from that of RelyX ARC regardless of the use of the chemical catalyst and light curing source. In conclusion, RelyX ARC can be cured satisfactorily with the argon ion laser, LED or quartz-tungsten-halogen light with or without a chemical catalyst. To obtain a satisfactory degree of conversion, Panavia F luting cement should be used with ED Primer and cured with halogen light.</description><identifier>ISSN: 0268-8921</identifier><identifier>EISSN: 1435-604X</identifier><identifier>DOI: 10.1007/s10103-010-0857-y</identifier><identifier>PMID: 21104286</identifier><identifier>CODEN: LMSCEZ</identifier><language>eng</language><publisher>London: Springer-Verlag</publisher><subject>Bisphenol A-Glycidyl Methacrylate - chemistry ; Catalysis ; Catalysts ; Cement ; Chemicals ; Curing Lights, Dental ; Dentistry ; Lasers ; Lasers, Gas ; Lighting - instrumentation ; Medicine ; Medicine &amp; Public Health ; Optical Devices ; Optics ; Original Article ; Photonics ; Polyethylene Glycols - chemistry ; Polymethacrylic Acids - chemistry ; Quantum Optics ; Resin Cements - chemistry ; Resins ; Spectroscopy, Fourier Transform Infrared</subject><ispartof>Lasers in medical science, 2012-01, Vol.27 (1), p.145-151</ispartof><rights>Springer-Verlag London Ltd 2010</rights><rights>Springer-Verlag London Ltd 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-23e03828d5a63106608447afd21d4686affbcd99d0fd00ba94e3cba5a2b93ff3</citedby><cites>FETCH-LOGICAL-c468t-23e03828d5a63106608447afd21d4686affbcd99d0fd00ba94e3cba5a2b93ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10103-010-0857-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10103-010-0857-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21104286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Souza-Junior, Eduardo José</creatorcontrib><creatorcontrib>Prieto, Lúcia Trazzi</creatorcontrib><creatorcontrib>Soares, Giulliana Panfiglio</creatorcontrib><creatorcontrib>dos Santos Dias, Carlos Tadeu</creatorcontrib><creatorcontrib>Aguiar, Flávio Henrique Baggio</creatorcontrib><creatorcontrib>Paulillo, Luís Alexandre Maffei Sartini</creatorcontrib><title>The effect of curing light and chemical catalyst on the degree of conversion of two dual cured resin luting cements</title><title>Lasers in medical science</title><addtitle>Lasers Med Sci</addtitle><addtitle>Lasers Med Sci</addtitle><description>The aim of this study was to evaluate the influence of different curing lights and chemical catalysts on the degree of conversion of resin luting cements. A total of 60 disk-shaped specimens of RelyX ARC or Panavia F of diameter 5 mm and thickness 0.5 mm were prepared and the respective chemical catalyst (Scotchbond Multi-Purpose Plus or ED Primer) was added. The specimens were light-cured using different curing units (an argon ion laser, an LED or a quartz-tungsten-halogen light) through shade A2 composite disks of diameter 10 mm and thickness 2 mm. After 24 h of dry storage at 37°C, the degree of conversion of the resin luting cements was measured by Fourier-transformed infrared spectroscopy. For statistical analysis, ANOVA and the Tukey test were used, with p  ≤ 0.05. Panavia F when used without catalyst and cured using the LED or the argon ion laser showed degree of conversion values significantly lower than RelyX ARC, with and without catalyst, and cured with any of the light sources. Therefore, the degree of conversion of Panavia F with ED Primer cured with the quartz-tungsten-halogen light was significantly different from that of RelyX ARC regardless of the use of the chemical catalyst and light curing source. In conclusion, RelyX ARC can be cured satisfactorily with the argon ion laser, LED or quartz-tungsten-halogen light with or without a chemical catalyst. To obtain a satisfactory degree of conversion, Panavia F luting cement should be used with ED Primer and cured with halogen light.</description><subject>Bisphenol A-Glycidyl Methacrylate - chemistry</subject><subject>Catalysis</subject><subject>Catalysts</subject><subject>Cement</subject><subject>Chemicals</subject><subject>Curing Lights, Dental</subject><subject>Dentistry</subject><subject>Lasers</subject><subject>Lasers, Gas</subject><subject>Lighting - instrumentation</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Original Article</subject><subject>Photonics</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polymethacrylic Acids - chemistry</subject><subject>Quantum Optics</subject><subject>Resin Cements - chemistry</subject><subject>Resins</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><issn>0268-8921</issn><issn>1435-604X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU2LFDEQhoMo7rj6A7xI8OKptSrpTqePsvgFC17m4C2kk8pML_0xJmll_r1pZ1UQxEuFkOd9K1UvY88RXiNA-yYhIMiqlAp001bnB2yHtWwqBfWXh2wHQulKdwKv2JOU7gCwVSgfsyuBCLXQasfS_kicQiCX-RK4W-MwH_g4HI6Z29lzd6RpcHbkzmY7nlOhZp6LxtMhEv3ULPM3imkoD-WWvy_cr5tgjeR5pDTMfFzzZutoojmnp-xRsGOiZ_fnNdu_f7e_-Vjdfv7w6ebtbeVqpXMlJIHUQvvGKomgFOi6bm3wAn0BlA2hd77rPAQP0NuuJul621jRdzIEec1eXWxPcfm6UspmGpKjcbQzLWsyXdmOltji_0lslGhR1YV8-Rd5t6xxLlNsEJQvqq5AeIFcXFKKFMwpDpONZ4NgtuDMJThTitmCM-eieXFvvPYT-d-KX0kVQFyAdNoiovin879dfwDmsaQk</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Souza-Junior, Eduardo José</creator><creator>Prieto, Lúcia Trazzi</creator><creator>Soares, Giulliana Panfiglio</creator><creator>dos Santos Dias, Carlos Tadeu</creator><creator>Aguiar, Flávio Henrique Baggio</creator><creator>Paulillo, Luís Alexandre Maffei Sartini</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7SP</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L7M</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120101</creationdate><title>The effect of curing light and chemical catalyst on the degree of conversion of two dual cured resin luting cements</title><author>Souza-Junior, Eduardo José ; Prieto, Lúcia Trazzi ; Soares, Giulliana Panfiglio ; dos Santos Dias, Carlos Tadeu ; Aguiar, Flávio Henrique Baggio ; Paulillo, Luís Alexandre Maffei Sartini</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-23e03828d5a63106608447afd21d4686affbcd99d0fd00ba94e3cba5a2b93ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Bisphenol A-Glycidyl Methacrylate - chemistry</topic><topic>Catalysis</topic><topic>Catalysts</topic><topic>Cement</topic><topic>Chemicals</topic><topic>Curing Lights, Dental</topic><topic>Dentistry</topic><topic>Lasers</topic><topic>Lasers, Gas</topic><topic>Lighting - instrumentation</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Optical Devices</topic><topic>Optics</topic><topic>Original Article</topic><topic>Photonics</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polymethacrylic Acids - chemistry</topic><topic>Quantum Optics</topic><topic>Resin Cements - chemistry</topic><topic>Resins</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Souza-Junior, Eduardo José</creatorcontrib><creatorcontrib>Prieto, Lúcia Trazzi</creatorcontrib><creatorcontrib>Soares, Giulliana Panfiglio</creatorcontrib><creatorcontrib>dos Santos Dias, Carlos Tadeu</creatorcontrib><creatorcontrib>Aguiar, Flávio Henrique Baggio</creatorcontrib><creatorcontrib>Paulillo, Luís Alexandre Maffei Sartini</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Electronics &amp; Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aerospace Database</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Lasers in medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Souza-Junior, Eduardo José</au><au>Prieto, Lúcia Trazzi</au><au>Soares, Giulliana Panfiglio</au><au>dos Santos Dias, Carlos Tadeu</au><au>Aguiar, Flávio Henrique Baggio</au><au>Paulillo, Luís Alexandre Maffei Sartini</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of curing light and chemical catalyst on the degree of conversion of two dual cured resin luting cements</atitle><jtitle>Lasers in medical science</jtitle><stitle>Lasers Med Sci</stitle><addtitle>Lasers Med Sci</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>27</volume><issue>1</issue><spage>145</spage><epage>151</epage><pages>145-151</pages><issn>0268-8921</issn><eissn>1435-604X</eissn><coden>LMSCEZ</coden><abstract>The aim of this study was to evaluate the influence of different curing lights and chemical catalysts on the degree of conversion of resin luting cements. A total of 60 disk-shaped specimens of RelyX ARC or Panavia F of diameter 5 mm and thickness 0.5 mm were prepared and the respective chemical catalyst (Scotchbond Multi-Purpose Plus or ED Primer) was added. The specimens were light-cured using different curing units (an argon ion laser, an LED or a quartz-tungsten-halogen light) through shade A2 composite disks of diameter 10 mm and thickness 2 mm. After 24 h of dry storage at 37°C, the degree of conversion of the resin luting cements was measured by Fourier-transformed infrared spectroscopy. For statistical analysis, ANOVA and the Tukey test were used, with p  ≤ 0.05. Panavia F when used without catalyst and cured using the LED or the argon ion laser showed degree of conversion values significantly lower than RelyX ARC, with and without catalyst, and cured with any of the light sources. Therefore, the degree of conversion of Panavia F with ED Primer cured with the quartz-tungsten-halogen light was significantly different from that of RelyX ARC regardless of the use of the chemical catalyst and light curing source. In conclusion, RelyX ARC can be cured satisfactorily with the argon ion laser, LED or quartz-tungsten-halogen light with or without a chemical catalyst. To obtain a satisfactory degree of conversion, Panavia F luting cement should be used with ED Primer and cured with halogen light.</abstract><cop>London</cop><pub>Springer-Verlag</pub><pmid>21104286</pmid><doi>10.1007/s10103-010-0857-y</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0268-8921
ispartof Lasers in medical science, 2012-01, Vol.27 (1), p.145-151
issn 0268-8921
1435-604X
language eng
recordid cdi_proquest_miscellaneous_926883171
source MEDLINE; SpringerNature Journals
subjects Bisphenol A-Glycidyl Methacrylate - chemistry
Catalysis
Catalysts
Cement
Chemicals
Curing Lights, Dental
Dentistry
Lasers
Lasers, Gas
Lighting - instrumentation
Medicine
Medicine & Public Health
Optical Devices
Optics
Original Article
Photonics
Polyethylene Glycols - chemistry
Polymethacrylic Acids - chemistry
Quantum Optics
Resin Cements - chemistry
Resins
Spectroscopy, Fourier Transform Infrared
title The effect of curing light and chemical catalyst on the degree of conversion of two dual cured resin luting cements
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T11%3A00%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effect%20of%20curing%20light%20and%20chemical%20catalyst%20on%20the%20degree%20of%20conversion%20of%20two%20dual%20cured%20resin%20luting%20cements&rft.jtitle=Lasers%20in%20medical%20science&rft.au=Souza-Junior,%20Eduardo%20Jos%C3%A9&rft.date=2012-01-01&rft.volume=27&rft.issue=1&rft.spage=145&rft.epage=151&rft.pages=145-151&rft.issn=0268-8921&rft.eissn=1435-604X&rft.coden=LMSCEZ&rft_id=info:doi/10.1007/s10103-010-0857-y&rft_dat=%3Cproquest_cross%3E915627164%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=915060869&rft_id=info:pmid/21104286&rfr_iscdi=true