The Effect of Different Ethoxylations for Sorbitan Monolaurate on Enhancing Simultaneous Saccharification and Fermentation (SSF) of Wheat Straw to Ethanol

In this paper, four nonionic surfactants with different hydrophilic–lipophilic balance (HLB) based on sorbitan monolaurate were synthesized by introducing ethylene oxide gas ( n  = 20, 40, 60, and 80 ethylene oxide units). The chemical structure of the prepared ethoxylated surfactants was confirmed...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Applied biochemistry and biotechnology 2012, Vol.166 (1), p.22-35
Hauptverfasser: Badawi, A. M., Fahmy, A. A., Mohamed, Karima A., Noor El-Din, M. R., Riad, M. G.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 35
container_issue 1
container_start_page 22
container_title Applied biochemistry and biotechnology
container_volume 166
creator Badawi, A. M.
Fahmy, A. A.
Mohamed, Karima A.
Noor El-Din, M. R.
Riad, M. G.
description In this paper, four nonionic surfactants with different hydrophilic–lipophilic balance (HLB) based on sorbitan monolaurate were synthesized by introducing ethylene oxide gas ( n  = 20, 40, 60, and 80 ethylene oxide units). The chemical structure of the prepared ethoxylated surfactants was confirmed using Fourier transform-infrared and 1 H NMR spectroscopes. The surface tension and thermodynamic properties of the prepared surfactants have been studied. The simultaneous saccharification and fermentation (SSF) process for ethanol production from microwave/alkali pretreated wheat straw has been assayed using nonionic surfactants have different ethylene oxide units. Ethanol yield was 82% and 61% for Kluyveromyces marxianus and Saccharomyces cerevisiae , respectively, with the addition of 2.5 g/l of the prepared nonionic surfactant (HLB = 18.2). Results show that the production of ethanol from microwave/alkali pretreated wheat straw increased with increasing the (HLB) value of the nonionic surfactant.
doi_str_mv 10.1007/s12010-011-9400-2
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_926883092</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>926883092</sourcerecordid><originalsourceid>FETCH-LOGICAL-c432t-ace7f35bde021824af35dd066a107888c352078f910efcef238b2ef8597ee17e3</originalsourceid><addsrcrecordid>eNqFkcFu1DAQhi0EokvhAbggCwkBh4DHiTf2EZVdQCrikCKOkdcZN6kSu9iOoK_C0-KQhUpIiJPH48__P6OfkMfAXgFj9esInAErGEChKsYKfodsQAhVMK7gLtkwXpcF51KdkAcxXjEGXIr6PjnhoGRVympDflz0SHfWoknUW_p2yGVAl-gu9f77zajT4F2k1gfa-HAYknb0o3d-1HPQCal3dOd67czgLmkzTPOYCfRzpI02ptdhsIP5JUK16-gew5TV18aLptm_XFy_9KgTbVLQ32jyi7XODg_JPavHiI-O5yn5vN9dnL0vzj-9-3D25rwwVclToQ3WthSHDhkHySudL13HtlsNrJZSmlLwXFgFDK1By0t54GilUDUi1Fiekuer7nXwX2eMqZ2GaHAc10VaxbdSlkzx_5NQbWtgUmTy6V_klZ-Dy2ssUJlTk5AhWCETfIwBbXsdhkmHmxZYuwTcrgG3OeB2CbhdRnhyFJ4PE3Z_fvxONAPPjoCORo82LNnEW04IqUAsQnzlYn5ylxhuJ_y3-0_Fk75M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>914301081</pqid></control><display><type>article</type><title>The Effect of Different Ethoxylations for Sorbitan Monolaurate on Enhancing Simultaneous Saccharification and Fermentation (SSF) of Wheat Straw to Ethanol</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Badawi, A. M. ; Fahmy, A. A. ; Mohamed, Karima A. ; Noor El-Din, M. R. ; Riad, M. G.</creator><creatorcontrib>Badawi, A. M. ; Fahmy, A. A. ; Mohamed, Karima A. ; Noor El-Din, M. R. ; Riad, M. G.</creatorcontrib><description>In this paper, four nonionic surfactants with different hydrophilic–lipophilic balance (HLB) based on sorbitan monolaurate were synthesized by introducing ethylene oxide gas ( n  = 20, 40, 60, and 80 ethylene oxide units). The chemical structure of the prepared ethoxylated surfactants was confirmed using Fourier transform-infrared and 1 H NMR spectroscopes. The surface tension and thermodynamic properties of the prepared surfactants have been studied. The simultaneous saccharification and fermentation (SSF) process for ethanol production from microwave/alkali pretreated wheat straw has been assayed using nonionic surfactants have different ethylene oxide units. Ethanol yield was 82% and 61% for Kluyveromyces marxianus and Saccharomyces cerevisiae , respectively, with the addition of 2.5 g/l of the prepared nonionic surfactant (HLB = 18.2). Results show that the production of ethanol from microwave/alkali pretreated wheat straw increased with increasing the (HLB) value of the nonionic surfactant.</description><identifier>ISSN: 0273-2289</identifier><identifier>EISSN: 1559-0291</identifier><identifier>DOI: 10.1007/s12010-011-9400-2</identifier><identifier>PMID: 21984384</identifier><identifier>CODEN: ABIBDL</identifier><language>eng</language><publisher>New York: Humana Press Inc</publisher><subject>Biochemistry ; Biological and medical sciences ; Biotechnology ; Chemical engineering ; Chemical synthesis ; Chemistry ; Chemistry and Materials Science ; Ethanol ; Ethanol - chemistry ; Ethanol - metabolism ; Ethylene Oxide - chemistry ; Fermentation ; Fourier Analysis ; Fourier transforms ; Fundamental and applied biological sciences. Psychology ; Hexoses - chemistry ; Hexoses - metabolism ; Kluyveromyces - chemistry ; Kluyveromyces - metabolism ; Kluyveromyces marxianus ; Lignin - chemistry ; Magnetic Resonance Spectroscopy ; Methods. Procedures. Technologies ; Microbial engineering. Fermentation and microbial culture technology ; Nonionic surfactants ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - chemistry ; Saccharomyces cerevisiae - metabolism ; Surface tension ; Surface-Active Agents - chemistry ; Surface-Active Agents - metabolism ; Surfactants ; Triticum - chemistry ; Triticum aestivum ; Wheat straw ; Yeast</subject><ispartof>Applied biochemistry and biotechnology, 2012, Vol.166 (1), p.22-35</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><rights>2015 INIST-CNRS</rights><rights>Springer Science+Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-ace7f35bde021824af35dd066a107888c352078f910efcef238b2ef8597ee17e3</citedby><cites>FETCH-LOGICAL-c432t-ace7f35bde021824af35dd066a107888c352078f910efcef238b2ef8597ee17e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12010-011-9400-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12010-011-9400-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=25589152$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21984384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Badawi, A. M.</creatorcontrib><creatorcontrib>Fahmy, A. A.</creatorcontrib><creatorcontrib>Mohamed, Karima A.</creatorcontrib><creatorcontrib>Noor El-Din, M. R.</creatorcontrib><creatorcontrib>Riad, M. G.</creatorcontrib><title>The Effect of Different Ethoxylations for Sorbitan Monolaurate on Enhancing Simultaneous Saccharification and Fermentation (SSF) of Wheat Straw to Ethanol</title><title>Applied biochemistry and biotechnology</title><addtitle>Appl Biochem Biotechnol</addtitle><addtitle>Appl Biochem Biotechnol</addtitle><description>In this paper, four nonionic surfactants with different hydrophilic–lipophilic balance (HLB) based on sorbitan monolaurate were synthesized by introducing ethylene oxide gas ( n  = 20, 40, 60, and 80 ethylene oxide units). The chemical structure of the prepared ethoxylated surfactants was confirmed using Fourier transform-infrared and 1 H NMR spectroscopes. The surface tension and thermodynamic properties of the prepared surfactants have been studied. The simultaneous saccharification and fermentation (SSF) process for ethanol production from microwave/alkali pretreated wheat straw has been assayed using nonionic surfactants have different ethylene oxide units. Ethanol yield was 82% and 61% for Kluyveromyces marxianus and Saccharomyces cerevisiae , respectively, with the addition of 2.5 g/l of the prepared nonionic surfactant (HLB = 18.2). Results show that the production of ethanol from microwave/alkali pretreated wheat straw increased with increasing the (HLB) value of the nonionic surfactant.</description><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Chemical engineering</subject><subject>Chemical synthesis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Ethanol</subject><subject>Ethanol - chemistry</subject><subject>Ethanol - metabolism</subject><subject>Ethylene Oxide - chemistry</subject><subject>Fermentation</subject><subject>Fourier Analysis</subject><subject>Fourier transforms</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hexoses - chemistry</subject><subject>Hexoses - metabolism</subject><subject>Kluyveromyces - chemistry</subject><subject>Kluyveromyces - metabolism</subject><subject>Kluyveromyces marxianus</subject><subject>Lignin - chemistry</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Methods. Procedures. Technologies</subject><subject>Microbial engineering. Fermentation and microbial culture technology</subject><subject>Nonionic surfactants</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - chemistry</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>Surface tension</subject><subject>Surface-Active Agents - chemistry</subject><subject>Surface-Active Agents - metabolism</subject><subject>Surfactants</subject><subject>Triticum - chemistry</subject><subject>Triticum aestivum</subject><subject>Wheat straw</subject><subject>Yeast</subject><issn>0273-2289</issn><issn>1559-0291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkcFu1DAQhi0EokvhAbggCwkBh4DHiTf2EZVdQCrikCKOkdcZN6kSu9iOoK_C0-KQhUpIiJPH48__P6OfkMfAXgFj9esInAErGEChKsYKfodsQAhVMK7gLtkwXpcF51KdkAcxXjEGXIr6PjnhoGRVympDflz0SHfWoknUW_p2yGVAl-gu9f77zajT4F2k1gfa-HAYknb0o3d-1HPQCal3dOd67czgLmkzTPOYCfRzpI02ptdhsIP5JUK16-gew5TV18aLptm_XFy_9KgTbVLQ32jyi7XODg_JPavHiI-O5yn5vN9dnL0vzj-9-3D25rwwVclToQ3WthSHDhkHySudL13HtlsNrJZSmlLwXFgFDK1By0t54GilUDUi1Fiekuer7nXwX2eMqZ2GaHAc10VaxbdSlkzx_5NQbWtgUmTy6V_klZ-Dy2ssUJlTk5AhWCETfIwBbXsdhkmHmxZYuwTcrgG3OeB2CbhdRnhyFJ4PE3Z_fvxONAPPjoCORo82LNnEW04IqUAsQnzlYn5ylxhuJ_y3-0_Fk75M</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Badawi, A. M.</creator><creator>Fahmy, A. A.</creator><creator>Mohamed, Karima A.</creator><creator>Noor El-Din, M. R.</creator><creator>Riad, M. G.</creator><general>Humana Press Inc</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7ST</scope><scope>7T7</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>SOI</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>2012</creationdate><title>The Effect of Different Ethoxylations for Sorbitan Monolaurate on Enhancing Simultaneous Saccharification and Fermentation (SSF) of Wheat Straw to Ethanol</title><author>Badawi, A. M. ; Fahmy, A. A. ; Mohamed, Karima A. ; Noor El-Din, M. R. ; Riad, M. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-ace7f35bde021824af35dd066a107888c352078f910efcef238b2ef8597ee17e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Chemical engineering</topic><topic>Chemical synthesis</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Ethanol</topic><topic>Ethanol - chemistry</topic><topic>Ethanol - metabolism</topic><topic>Ethylene Oxide - chemistry</topic><topic>Fermentation</topic><topic>Fourier Analysis</topic><topic>Fourier transforms</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hexoses - chemistry</topic><topic>Hexoses - metabolism</topic><topic>Kluyveromyces - chemistry</topic><topic>Kluyveromyces - metabolism</topic><topic>Kluyveromyces marxianus</topic><topic>Lignin - chemistry</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Methods. Procedures. Technologies</topic><topic>Microbial engineering. Fermentation and microbial culture technology</topic><topic>Nonionic surfactants</topic><topic>Saccharomyces cerevisiae</topic><topic>Saccharomyces cerevisiae - chemistry</topic><topic>Saccharomyces cerevisiae - metabolism</topic><topic>Surface tension</topic><topic>Surface-Active Agents - chemistry</topic><topic>Surface-Active Agents - metabolism</topic><topic>Surfactants</topic><topic>Triticum - chemistry</topic><topic>Triticum aestivum</topic><topic>Wheat straw</topic><topic>Yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Badawi, A. M.</creatorcontrib><creatorcontrib>Fahmy, A. A.</creatorcontrib><creatorcontrib>Mohamed, Karima A.</creatorcontrib><creatorcontrib>Noor El-Din, M. R.</creatorcontrib><creatorcontrib>Riad, M. G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Applied biochemistry and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Badawi, A. M.</au><au>Fahmy, A. A.</au><au>Mohamed, Karima A.</au><au>Noor El-Din, M. R.</au><au>Riad, M. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Different Ethoxylations for Sorbitan Monolaurate on Enhancing Simultaneous Saccharification and Fermentation (SSF) of Wheat Straw to Ethanol</atitle><jtitle>Applied biochemistry and biotechnology</jtitle><stitle>Appl Biochem Biotechnol</stitle><addtitle>Appl Biochem Biotechnol</addtitle><date>2012</date><risdate>2012</risdate><volume>166</volume><issue>1</issue><spage>22</spage><epage>35</epage><pages>22-35</pages><issn>0273-2289</issn><eissn>1559-0291</eissn><coden>ABIBDL</coden><abstract>In this paper, four nonionic surfactants with different hydrophilic–lipophilic balance (HLB) based on sorbitan monolaurate were synthesized by introducing ethylene oxide gas ( n  = 20, 40, 60, and 80 ethylene oxide units). The chemical structure of the prepared ethoxylated surfactants was confirmed using Fourier transform-infrared and 1 H NMR spectroscopes. The surface tension and thermodynamic properties of the prepared surfactants have been studied. The simultaneous saccharification and fermentation (SSF) process for ethanol production from microwave/alkali pretreated wheat straw has been assayed using nonionic surfactants have different ethylene oxide units. Ethanol yield was 82% and 61% for Kluyveromyces marxianus and Saccharomyces cerevisiae , respectively, with the addition of 2.5 g/l of the prepared nonionic surfactant (HLB = 18.2). Results show that the production of ethanol from microwave/alkali pretreated wheat straw increased with increasing the (HLB) value of the nonionic surfactant.</abstract><cop>New York</cop><pub>Humana Press Inc</pub><pmid>21984384</pmid><doi>10.1007/s12010-011-9400-2</doi><tpages>14</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0273-2289
ispartof Applied biochemistry and biotechnology, 2012, Vol.166 (1), p.22-35
issn 0273-2289
1559-0291
language eng
recordid cdi_proquest_miscellaneous_926883092
source MEDLINE; SpringerLink Journals - AutoHoldings
subjects Biochemistry
Biological and medical sciences
Biotechnology
Chemical engineering
Chemical synthesis
Chemistry
Chemistry and Materials Science
Ethanol
Ethanol - chemistry
Ethanol - metabolism
Ethylene Oxide - chemistry
Fermentation
Fourier Analysis
Fourier transforms
Fundamental and applied biological sciences. Psychology
Hexoses - chemistry
Hexoses - metabolism
Kluyveromyces - chemistry
Kluyveromyces - metabolism
Kluyveromyces marxianus
Lignin - chemistry
Magnetic Resonance Spectroscopy
Methods. Procedures. Technologies
Microbial engineering. Fermentation and microbial culture technology
Nonionic surfactants
Saccharomyces cerevisiae
Saccharomyces cerevisiae - chemistry
Saccharomyces cerevisiae - metabolism
Surface tension
Surface-Active Agents - chemistry
Surface-Active Agents - metabolism
Surfactants
Triticum - chemistry
Triticum aestivum
Wheat straw
Yeast
title The Effect of Different Ethoxylations for Sorbitan Monolaurate on Enhancing Simultaneous Saccharification and Fermentation (SSF) of Wheat Straw to Ethanol
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T10%3A54%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Effect%20of%20Different%20Ethoxylations%20for%20Sorbitan%20Monolaurate%20on%20Enhancing%20Simultaneous%20Saccharification%20and%20Fermentation%20(SSF)%20of%20Wheat%20Straw%20to%20Ethanol&rft.jtitle=Applied%20biochemistry%20and%20biotechnology&rft.au=Badawi,%20A.%20M.&rft.date=2012&rft.volume=166&rft.issue=1&rft.spage=22&rft.epage=35&rft.pages=22-35&rft.issn=0273-2289&rft.eissn=1559-0291&rft.coden=ABIBDL&rft_id=info:doi/10.1007/s12010-011-9400-2&rft_dat=%3Cproquest_cross%3E926883092%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=914301081&rft_id=info:pmid/21984384&rfr_iscdi=true