Genetic polymorphisms in TNFA/TNFR2 genes and Chagas disease in a Colombian endemic population

► About 15–30% of individuals infected by Trypanosoma cruzi develop clinical symptoms. ► Chagas’ disease is characterized by heart inflammation and dysfunction. ► We studied the association of genetic variants of TNFA and TNFR2 in Chagas’ disease. ► TNFA -1031C and -308A alleles are associated with...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2012-03, Vol.57 (3), p.398-401
Hauptverfasser:	Criado, Libeth, Flórez, Oscar, Martín, Javier, González, Clara Isabel
Format:	Artikel
Sprache:	eng
Schlagworte:	alleles antigens cardiomyopathy Chagas disease Chagas Disease - epidemiology Chagas Disease - genetics Colombia Colombia - epidemiology cytokines Endemic Diseases Gene Frequency - genetics Genetic Predisposition to Disease genotype Haplotypes - genetics Humans Middle Aged necrosis patients polymerase chain reaction Polymorphism, Single Nucleotide - genetics Receptors, Tumor Necrosis Factor, Type II - genetics single nucleotide polymorphism Single nucleotide polymorphisms Trypanosoma cruzi Tumor necrosis factor-alfa Tumor Necrosis Factor-alpha - genetics
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