Production of bioactive sheep β-defensin-1 in Pichia pastoris

Previous research has shown that sheep β-defensin-1 (sBD-1), a small cationic peptide with a broad range of antimicrobial activities, could inhibit the growth of both Gram-positive and Gram-negative bacteria as well as that of fungi. In order to increase the yield of current ovine defensin purificat...

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Veröffentlicht in:	Journal of industrial microbiology & biotechnology 2012, Vol.39 (1), p.11-17
Hauptverfasser:	Zhao, Pengwei, Cao, Guifang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Anti-Infective Agents - chemistry Anti-Infective Agents - metabolism Anti-Infective Agents - pharmacology antimicrobial properties beta-Defensins - biosynthesis beta-Defensins - genetics beta-Defensins - pharmacology Biochemistry Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biotechnology Escherichia coli Fundamental and applied biological sciences. Psychology fungi Fungi - drug effects Genetic Engineering Gram-negative bacteria Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Inorganic Chemistry Life Sciences Microbiology Molecular Sequence Data Original Paper peptides Pichia - genetics Pichia - metabolism Pichia pastoris Proteus vulgaris Pseudomonas aeruginosa purification methods Sheep Shigella flexneri Staphylococcus aureus
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