Promoter methylation status of VEGF receptor genes: A possible epigenetic biomarker to anticipate the efficacy of intracellular-acting VEGF-targeted drugs in cancer cells

We evaluated whether the inhibitory effects of vascular endothelial growth factor (VEGF)-targeted drugs on the proliferation of cancer cells differed according to VEGF receptor (VEGFR) genes, Flt1 and KDR, promoter methylation status. Five hyper-VEGFR-methylation and six no-VEGFR-methylation cancer...

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Veröffentlicht in:	Epigenetics 2012-02, Vol.7 (2), p.191-200
Hauptverfasser:	Kim, Jeeyeon, Hwang, Junha, Jeong, Hyeseon, Song, Hee-Jung, Shin, Jieun, Hur, Gangmin, Park, Young Woo, Lee, Suk Hoon, Kim, Jei
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Binding Biology Biomarkers, Tumor - genetics Bioscience Calcium Cancer Cell Cell Line, Tumor Cell Proliferation - drug effects CpG Islands - genetics Cycle DNA Methylation - drug effects DNA Methylation - genetics Epigenesis, Genetic - drug effects epigenetic change Extracellular Signal-Regulated MAP Kinases - metabolism Flt1 Human Umbilical Vein Endothelial Cells - metabolism Humans Intracellular Space - drug effects Intracellular Space - metabolism KDR Landes Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - genetics Neoplasms - pathology Organogenesis Phosphorylation - drug effects promoter hypermethylation Promoter Regions, Genetic - genetics Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Proteins Proto-Oncogene Proteins c-akt - metabolism Receptors, Vascular Endothelial Growth Factor - genetics Treatment Outcome vascular endothelial growth factor (VEGF) Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - metabolism VEGF receptor (VEGFR) VEGF-specific antibody VEGF-specific tyrosine kinase inhibitor VEGF-targeted drug VEGFR2-specific antibody
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