Protection Against Staphylococcus aureus by Antibody to the Polyglycerolphosphate Backbone of Heterologous Lipoteichoic Acid
Type 1 lipoteichoic acid (LTA) is present in many clinically important gram-positive bacteria, including enterococci, streptococci, and staphylococci, and antibodies against LTA have been shown to opsonize nonencapsulated Enterococcus faecalis strains. In the present study, we show that antibodies a...
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| Veröffentlicht in: | The Journal of infectious diseases 2012-04, Vol.205 (7), p.1076-1085 |
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| creator | Theilacker, Christian Kropec, Andrea Hammer, Felix Sava, Irina Wobser, Dominique Sakinc, Tuerkan Codée, Jeroen D. C. Hogendorf, Wouter F. J. van der Marel, Gijsbert A. Huebner, Johannes |
| description | Type 1 lipoteichoic acid (LTA) is present in many clinically important gram-positive bacteria, including enterococci, streptococci, and staphylococci, and antibodies against LTA have been shown to opsonize nonencapsulated Enterococcus faecalis strains. In the present study, we show that antibodies against E. faecalis LTA also bind to type 1 LTA from other gram-positive species and opsonized Staphylocccus epidermidis and Staphylcoccus aureus strains as well as group  streptococci. Inhibition studies using teichoic acid oligomers indicated that cross-reactive opsonic antibodies bind to the teichoic acid backbone. Passive immunization with rabbit antibodies against E, faecalis LTA promoted the clearance of bacteremia by E. faecalis and S. epidermidis in mice. Furthermore, passive protection also reduced mortality in a murine S. aureus peritonitis model. The effectiveness of rabbit antibody against LTA suggests that this conserved bacterial structure could function as a single vaccine antigen that targets multiple gram-positive pathogens. |
| doi_str_mv | 10.1093/infdis/jis022 |
| format | Article |
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Passive immunization with rabbit antibodies against E, faecalis LTA promoted the clearance of bacteremia by E. faecalis and S. epidermidis in mice. Furthermore, passive protection also reduced mortality in a murine S. aureus peritonitis model. The effectiveness of rabbit antibody against LTA suggests that this conserved bacterial structure could function as a single vaccine antigen that targets multiple gram-positive pathogens.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jis022</identifier><identifier>PMID: 22362863</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Animals ; Antibodies ; Antibodies, Bacterial - administration & dosage ; Antibodies, Bacterial - immunology ; Antigens ; Antigens, Bacterial - immunology ; Antiserum ; Bacteremia - prevention & control ; Bacteria ; Bacteriology ; Biological and medical sciences ; Disease Models, Animal ; Enterococcus faecalis ; Enterococcus faecalis - immunology ; Female ; Fundamental and applied biological sciences. Psychology ; Glycerophosphates - immunology ; Gram positive bacteria ; Human Experimentation ; Humans ; Immunization, Passive - methods ; Infectious diseases ; Lipopolysaccharides - immunology ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Microbiology ; Miscellaneous ; Opsonin Proteins - immunology ; Peritonitis - prevention & control ; Phagocytosis ; Polysaccharides ; Rabbits ; Staphylococcal Infections - immunology ; Staphylococcal Infections - microbiology ; Staphylococcal Infections - prevention & control ; Staphylococcus aureus ; Staphylococcus aureus - immunology ; Staphylococcus epidermidis - immunology ; Streptococcus agalactiae - immunology ; Survival Analysis ; Teichoic acids ; Teichoic Acids - immunology ; Vaccination</subject><ispartof>The Journal of infectious diseases, 2012-04, Vol.205 (7), p.1076-1085</ispartof><rights>Copyright © 2012 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-90bf1bff8c0400b7c5467697cffceda6675cdb74eba070302c15d452b918c5fe3</citedby><cites>FETCH-LOGICAL-c449t-90bf1bff8c0400b7c5467697cffceda6675cdb74eba070302c15d452b918c5fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41417819$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41417819$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,800,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25866849$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22362863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Theilacker, Christian</creatorcontrib><creatorcontrib>Kropec, Andrea</creatorcontrib><creatorcontrib>Hammer, Felix</creatorcontrib><creatorcontrib>Sava, Irina</creatorcontrib><creatorcontrib>Wobser, Dominique</creatorcontrib><creatorcontrib>Sakinc, Tuerkan</creatorcontrib><creatorcontrib>Codée, Jeroen D. C.</creatorcontrib><creatorcontrib>Hogendorf, Wouter F. J.</creatorcontrib><creatorcontrib>van der Marel, Gijsbert A.</creatorcontrib><creatorcontrib>Huebner, Johannes</creatorcontrib><title>Protection Against Staphylococcus aureus by Antibody to the Polyglycerolphosphate Backbone of Heterologous Lipoteichoic Acid</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Type 1 lipoteichoic acid (LTA) is present in many clinically important gram-positive bacteria, including enterococci, streptococci, and staphylococci, and antibodies against LTA have been shown to opsonize nonencapsulated Enterococcus faecalis strains. In the present study, we show that antibodies against E. faecalis LTA also bind to type 1 LTA from other gram-positive species and opsonized Staphylocccus epidermidis and Staphylcoccus aureus strains as well as group  streptococci. Inhibition studies using teichoic acid oligomers indicated that cross-reactive opsonic antibodies bind to the teichoic acid backbone. Passive immunization with rabbit antibodies against E, faecalis LTA promoted the clearance of bacteremia by E. faecalis and S. epidermidis in mice. Furthermore, passive protection also reduced mortality in a murine S. aureus peritonitis model. The effectiveness of rabbit antibody against LTA suggests that this conserved bacterial structure could function as a single vaccine antigen that targets multiple gram-positive pathogens.</description><subject>Adult</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - administration & dosage</subject><subject>Antibodies, Bacterial - immunology</subject><subject>Antigens</subject><subject>Antigens, Bacterial - immunology</subject><subject>Antiserum</subject><subject>Bacteremia - prevention & control</subject><subject>Bacteria</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Enterococcus faecalis</subject><subject>Enterococcus faecalis - immunology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycerophosphates - immunology</subject><subject>Gram positive bacteria</subject><subject>Human Experimentation</subject><subject>Humans</subject><subject>Immunization, Passive - methods</subject><subject>Infectious diseases</subject><subject>Lipopolysaccharides - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Opsonin Proteins - immunology</subject><subject>Peritonitis - prevention & control</subject><subject>Phagocytosis</subject><subject>Polysaccharides</subject><subject>Rabbits</subject><subject>Staphylococcal Infections - immunology</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcal Infections - prevention & control</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - immunology</subject><subject>Staphylococcus epidermidis - immunology</subject><subject>Streptococcus agalactiae - immunology</subject><subject>Survival Analysis</subject><subject>Teichoic acids</subject><subject>Teichoic Acids - immunology</subject><subject>Vaccination</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90MGP1CAUBnBiNO7s6tGjhovxVBcKhXKc3eiuySRuop4beIUpY6dUYA5N_ONl03FOL-H9-CAfQu8o-UyJYrd-cr1PtwefSF2_QBvaMFkJQdlLtCHlqKKtUlfoOqUDIYQzIV-jq7pmom4F26C_TzFkC9mHCW_32k8p4x9Zz8MyBggAp4T1KdoyzIK3U_Ym9AvOAefB4qcwLvtxARvDOA8hzYPOFt9p-G3CZHFw-NHm52XYh5Kw83N5y8MQPOAt-P4NeuX0mOzb87xBv75--Xn_WO2-P3y73-4q4FzlShHjqHGuBcIJMRIaLqRQEpwD22shZAO9kdwaTSRhpAba9LypjaItNM6yG_RpzZ1j-HOyKXdHn8COo55s-VinatFKqSgvslolxJBStK6boz_quHSUdM99d2vf3dp38R_OySdztP1F_y-4gI9noBPo0UU9Qbl-cU0rRMtVce9Xd0g5xMueU05lSxX7B5P7l9A</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Theilacker, Christian</creator><creator>Kropec, Andrea</creator><creator>Hammer, Felix</creator><creator>Sava, Irina</creator><creator>Wobser, Dominique</creator><creator>Sakinc, Tuerkan</creator><creator>Codée, Jeroen D. 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J. ; van der Marel, Gijsbert A. ; Huebner, Johannes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-90bf1bff8c0400b7c5467697cffceda6675cdb74eba070302c15d452b918c5fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial - administration & dosage</topic><topic>Antibodies, Bacterial - immunology</topic><topic>Antigens</topic><topic>Antigens, Bacterial - immunology</topic><topic>Antiserum</topic><topic>Bacteremia - prevention & control</topic><topic>Bacteria</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Enterococcus faecalis</topic><topic>Enterococcus faecalis - immunology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycerophosphates - immunology</topic><topic>Gram positive bacteria</topic><topic>Human Experimentation</topic><topic>Humans</topic><topic>Immunization, Passive - methods</topic><topic>Infectious diseases</topic><topic>Lipopolysaccharides - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Opsonin Proteins - immunology</topic><topic>Peritonitis - prevention & control</topic><topic>Phagocytosis</topic><topic>Polysaccharides</topic><topic>Rabbits</topic><topic>Staphylococcal Infections - immunology</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcal Infections - prevention & control</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - immunology</topic><topic>Staphylococcus epidermidis - immunology</topic><topic>Streptococcus agalactiae - immunology</topic><topic>Survival Analysis</topic><topic>Teichoic acids</topic><topic>Teichoic Acids - immunology</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Theilacker, Christian</creatorcontrib><creatorcontrib>Kropec, Andrea</creatorcontrib><creatorcontrib>Hammer, Felix</creatorcontrib><creatorcontrib>Sava, Irina</creatorcontrib><creatorcontrib>Wobser, Dominique</creatorcontrib><creatorcontrib>Sakinc, Tuerkan</creatorcontrib><creatorcontrib>Codée, Jeroen D. C.</creatorcontrib><creatorcontrib>Hogendorf, Wouter F. J.</creatorcontrib><creatorcontrib>van der Marel, Gijsbert A.</creatorcontrib><creatorcontrib>Huebner, Johannes</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Theilacker, Christian</au><au>Kropec, Andrea</au><au>Hammer, Felix</au><au>Sava, Irina</au><au>Wobser, Dominique</au><au>Sakinc, Tuerkan</au><au>Codée, Jeroen D. C.</au><au>Hogendorf, Wouter F. J.</au><au>van der Marel, Gijsbert A.</au><au>Huebner, Johannes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protection Against Staphylococcus aureus by Antibody to the Polyglycerolphosphate Backbone of Heterologous Lipoteichoic Acid</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>205</volume><issue>7</issue><spage>1076</spage><epage>1085</epage><pages>1076-1085</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Type 1 lipoteichoic acid (LTA) is present in many clinically important gram-positive bacteria, including enterococci, streptococci, and staphylococci, and antibodies against LTA have been shown to opsonize nonencapsulated Enterococcus faecalis strains. In the present study, we show that antibodies against E. faecalis LTA also bind to type 1 LTA from other gram-positive species and opsonized Staphylocccus epidermidis and Staphylcoccus aureus strains as well as group  streptococci. Inhibition studies using teichoic acid oligomers indicated that cross-reactive opsonic antibodies bind to the teichoic acid backbone. Passive immunization with rabbit antibodies against E, faecalis LTA promoted the clearance of bacteremia by E. faecalis and S. epidermidis in mice. Furthermore, passive protection also reduced mortality in a murine S. aureus peritonitis model. The effectiveness of rabbit antibody against LTA suggests that this conserved bacterial structure could function as a single vaccine antigen that targets multiple gram-positive pathogens.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>22362863</pmid><doi>10.1093/infdis/jis022</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 2012-04, Vol.205 (7), p.1076-1085 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | MEDLINE; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Animals Antibodies Antibodies, Bacterial - administration & dosage Antibodies, Bacterial - immunology Antigens Antigens, Bacterial - immunology Antiserum Bacteremia - prevention & control Bacteria Bacteriology Biological and medical sciences Disease Models, Animal Enterococcus faecalis Enterococcus faecalis - immunology Female Fundamental and applied biological sciences. Psychology Glycerophosphates - immunology Gram positive bacteria Human Experimentation Humans Immunization, Passive - methods Infectious diseases Lipopolysaccharides - immunology Medical sciences Mice Mice, Inbred BALB C Microbiology Miscellaneous Opsonin Proteins - immunology Peritonitis - prevention & control Phagocytosis Polysaccharides Rabbits Staphylococcal Infections - immunology Staphylococcal Infections - microbiology Staphylococcal Infections - prevention & control Staphylococcus aureus Staphylococcus aureus - immunology Staphylococcus epidermidis - immunology Streptococcus agalactiae - immunology Survival Analysis Teichoic acids Teichoic Acids - immunology Vaccination |
| title | Protection Against Staphylococcus aureus by Antibody to the Polyglycerolphosphate Backbone of Heterologous Lipoteichoic Acid |
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