Iron accumulation in human spleen in autoimmune thrombocytopenia and hereditary spherocytosis
Although the iron is an essential element for the physiological functions of cells, tissues and organs, it is also an important inductor of reactive oxygen species (ROS). Three groups of human spleen with autoimmune thrombocytopenia (AITP), hereditary spherocytosis (HS) and reference samples stained...
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| Veröffentlicht in: | Bratislava Medical Journal 2012, Vol.113 (2), p.92-94 |
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| container_title | Bratislava Medical Journal |
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| creator | Biro, C Kopani, M Kopaniova, A Zitnanova, I El-Hassoun, O Minoo, P Kolenova, L Sisovsky, V Caplovicova, M Stvrtina, S Galfiova, P Guller, L Jakubovsky, J |
| description | Although the iron is an essential element for the physiological functions of cells, tissues and organs, it is also an important inductor of reactive oxygen species (ROS).
Three groups of human spleen with autoimmune thrombocytopenia (AITP), hereditary spherocytosis (HS) and reference samples stained by haematoxylin and eosin, Perls' reaction for nonheme Fe(III) iron and Alcian blue for glycoconjugates detection were studied.
Positive Perls' reaction in both AITP and HS groups was seen. Higher positivity in the HS than in AITP group was observed. HS group showed a higher amount of acidic glycoconjugates deposits than AITP group. Iron overload in HS and AITP leads to overproduction of ROS.
We suggest that acidic glycoconjugates deposits are involved in antioxidant defence by elimination and restriction of iron as a ROS inducer (Fig. 4, Ref. 19). |
| doi_str_mv | 10.4149//BLL_2012_021 |
| format | Article |
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Three groups of human spleen with autoimmune thrombocytopenia (AITP), hereditary spherocytosis (HS) and reference samples stained by haematoxylin and eosin, Perls' reaction for nonheme Fe(III) iron and Alcian blue for glycoconjugates detection were studied.
Positive Perls' reaction in both AITP and HS groups was seen. Higher positivity in the HS than in AITP group was observed. HS group showed a higher amount of acidic glycoconjugates deposits than AITP group. Iron overload in HS and AITP leads to overproduction of ROS.
We suggest that acidic glycoconjugates deposits are involved in antioxidant defence by elimination and restriction of iron as a ROS inducer (Fig. 4, Ref. 19).</description><identifier>ISSN: 0006-9248</identifier><identifier>ISSN: 1336-0345</identifier><identifier>EISSN: 1336-0345</identifier><identifier>DOI: 10.4149//BLL_2012_021</identifier><identifier>PMID: 22394038</identifier><language>eng</language><publisher>Slovakia</publisher><subject>Ferric Compounds - metabolism ; Glycoconjugates - metabolism ; Histocytochemistry ; Humans ; Purpura, Thrombocytopenic, Idiopathic - metabolism ; Reactive Oxygen Species - metabolism ; Spherocytosis, Hereditary - metabolism ; Spleen - metabolism</subject><ispartof>Bratislava Medical Journal, 2012, Vol.113 (2), p.92-94</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-c44fcbff81a0e82f7d6686ff2db320dbaecb05ed80b5df55bf383cbb071f3053</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22394038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Biro, C</creatorcontrib><creatorcontrib>Kopani, M</creatorcontrib><creatorcontrib>Kopaniova, A</creatorcontrib><creatorcontrib>Zitnanova, I</creatorcontrib><creatorcontrib>El-Hassoun, O</creatorcontrib><creatorcontrib>Minoo, P</creatorcontrib><creatorcontrib>Kolenova, L</creatorcontrib><creatorcontrib>Sisovsky, V</creatorcontrib><creatorcontrib>Caplovicova, M</creatorcontrib><creatorcontrib>Stvrtina, S</creatorcontrib><creatorcontrib>Galfiova, P</creatorcontrib><creatorcontrib>Guller, L</creatorcontrib><creatorcontrib>Jakubovsky, J</creatorcontrib><title>Iron accumulation in human spleen in autoimmune thrombocytopenia and hereditary spherocytosis</title><title>Bratislava Medical Journal</title><addtitle>Bratisl Lek Listy</addtitle><description>Although the iron is an essential element for the physiological functions of cells, tissues and organs, it is also an important inductor of reactive oxygen species (ROS).
Three groups of human spleen with autoimmune thrombocytopenia (AITP), hereditary spherocytosis (HS) and reference samples stained by haematoxylin and eosin, Perls' reaction for nonheme Fe(III) iron and Alcian blue for glycoconjugates detection were studied.
Positive Perls' reaction in both AITP and HS groups was seen. Higher positivity in the HS than in AITP group was observed. HS group showed a higher amount of acidic glycoconjugates deposits than AITP group. Iron overload in HS and AITP leads to overproduction of ROS.
We suggest that acidic glycoconjugates deposits are involved in antioxidant defence by elimination and restriction of iron as a ROS inducer (Fig. 4, Ref. 19).</description><subject>Ferric Compounds - metabolism</subject><subject>Glycoconjugates - metabolism</subject><subject>Histocytochemistry</subject><subject>Humans</subject><subject>Purpura, Thrombocytopenic, Idiopathic - metabolism</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Spherocytosis, Hereditary - metabolism</subject><subject>Spleen - metabolism</subject><issn>0006-9248</issn><issn>1336-0345</issn><issn>1336-0345</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkDtPwzAURi0EoqUwsqJsTKHXjyTuCBWPSpFYuiLLT9UoiUMcD_33hLYgpqtP99xPVwehWwwPDLPVcvlU14IAJgIIPkNzTGmZA2XFOZoDQJmvCOMzdBXjJwCjBS4v0YwQumJA-Rx9bIbQZVLr1KZGjn4Kvst2qZVdFvvG2kOWaQy-bVNns3E3hFYFvR9DbzsvM9mZbGcHa_woh_10NIXDOvp4jS6cbKK9Oc0F2r48b9dvef3-ulk_1rmmJRlzzZjTyjmOJVhOXGXKkpfOEaMoAaOk1QoKaziowriiUI5yqpWCCjsKBV2g-2NtP4SvZOMoWh-1bRrZ2ZCiWJGSVxXhdCLzI6mHEONgnegH305_Cwzix6cQ_31O_N2pOanWmj_6VyD9Bub2dA0</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Biro, C</creator><creator>Kopani, M</creator><creator>Kopaniova, A</creator><creator>Zitnanova, I</creator><creator>El-Hassoun, O</creator><creator>Minoo, P</creator><creator>Kolenova, L</creator><creator>Sisovsky, V</creator><creator>Caplovicova, M</creator><creator>Stvrtina, S</creator><creator>Galfiova, P</creator><creator>Guller, L</creator><creator>Jakubovsky, J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>Iron accumulation in human spleen in autoimmune thrombocytopenia and hereditary spherocytosis</title><author>Biro, C ; Kopani, M ; Kopaniova, A ; Zitnanova, I ; El-Hassoun, O ; Minoo, P ; Kolenova, L ; Sisovsky, V ; Caplovicova, M ; Stvrtina, S ; Galfiova, P ; Guller, L ; Jakubovsky, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-c44fcbff81a0e82f7d6686ff2db320dbaecb05ed80b5df55bf383cbb071f3053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Ferric Compounds - metabolism</topic><topic>Glycoconjugates - metabolism</topic><topic>Histocytochemistry</topic><topic>Humans</topic><topic>Purpura, Thrombocytopenic, Idiopathic - metabolism</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Spherocytosis, Hereditary - metabolism</topic><topic>Spleen - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Biro, C</creatorcontrib><creatorcontrib>Kopani, M</creatorcontrib><creatorcontrib>Kopaniova, A</creatorcontrib><creatorcontrib>Zitnanova, I</creatorcontrib><creatorcontrib>El-Hassoun, O</creatorcontrib><creatorcontrib>Minoo, P</creatorcontrib><creatorcontrib>Kolenova, L</creatorcontrib><creatorcontrib>Sisovsky, V</creatorcontrib><creatorcontrib>Caplovicova, M</creatorcontrib><creatorcontrib>Stvrtina, S</creatorcontrib><creatorcontrib>Galfiova, P</creatorcontrib><creatorcontrib>Guller, L</creatorcontrib><creatorcontrib>Jakubovsky, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bratislava Medical Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Biro, C</au><au>Kopani, M</au><au>Kopaniova, A</au><au>Zitnanova, I</au><au>El-Hassoun, O</au><au>Minoo, P</au><au>Kolenova, L</au><au>Sisovsky, V</au><au>Caplovicova, M</au><au>Stvrtina, S</au><au>Galfiova, P</au><au>Guller, L</au><au>Jakubovsky, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iron accumulation in human spleen in autoimmune thrombocytopenia and hereditary spherocytosis</atitle><jtitle>Bratislava Medical Journal</jtitle><addtitle>Bratisl Lek Listy</addtitle><date>2012</date><risdate>2012</risdate><volume>113</volume><issue>2</issue><spage>92</spage><epage>94</epage><pages>92-94</pages><issn>0006-9248</issn><issn>1336-0345</issn><eissn>1336-0345</eissn><abstract>Although the iron is an essential element for the physiological functions of cells, tissues and organs, it is also an important inductor of reactive oxygen species (ROS).
Three groups of human spleen with autoimmune thrombocytopenia (AITP), hereditary spherocytosis (HS) and reference samples stained by haematoxylin and eosin, Perls' reaction for nonheme Fe(III) iron and Alcian blue for glycoconjugates detection were studied.
Positive Perls' reaction in both AITP and HS groups was seen. Higher positivity in the HS than in AITP group was observed. HS group showed a higher amount of acidic glycoconjugates deposits than AITP group. Iron overload in HS and AITP leads to overproduction of ROS.
We suggest that acidic glycoconjugates deposits are involved in antioxidant defence by elimination and restriction of iron as a ROS inducer (Fig. 4, Ref. 19).</abstract><cop>Slovakia</cop><pmid>22394038</pmid><doi>10.4149//BLL_2012_021</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Ferric Compounds - metabolism Glycoconjugates - metabolism Histocytochemistry Humans Purpura, Thrombocytopenic, Idiopathic - metabolism Reactive Oxygen Species - metabolism Spherocytosis, Hereditary - metabolism Spleen - metabolism |
| title | Iron accumulation in human spleen in autoimmune thrombocytopenia and hereditary spherocytosis |
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