O-GlcNAc modification of the anti-malarial vaccine candidate PfAMA1: in silico-defined structural changes and potential to generate a better vaccine

The complex life cycle of plasmodial parasites makes the selection of a single subunit protein a less than optimal strategy to generate an efficient vaccinal protection against malaria. Moreover, the full protection afforded by malarial proteins carried by intact parasites implies that immune respon...

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Veröffentlicht in:	Molecular biology reports 2012-04, Vol.39 (4), p.4663-4672
Hauptverfasser:	Uddin, Nasir, Hoessli, Daniel C., Butt, Asma, Kaleem, Afshan, Iqbal, Zeeshan, Afzal, Imran, Muhammad Hammad, Zamani, Zahra, Shakoori, Abdul Rauf
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - metabolism Amino Acid Sequence Amino Acids - metabolism Animal Anatomy Animal Biochemistry Antigens Biomedical and Life Sciences Computational Biology Glycosylation Histology Humans Hydrogen Bonding Immunology Life Sciences Malaria Malaria Vaccines - immunology Models, Molecular Molecular biology Molecular Sequence Data Morphology N-Acetylglucosaminyltransferases - chemistry Plasmodium falciparum - immunology Protein Processing, Post-Translational Protein Structure, Secondary Protozoan Proteins - chemistry Protozoan Proteins - immunology Sequence Alignment Vaccines
Online-Zugang:	Volltext
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