IDH1 / 2 mutations in WHO grade II astrocytomas associated with localization and seizure as the initial symptom

Abstract Introduction Seizures are the most common initial symptom in patients with low-grade glioma and their occurrence strongly depends on the tumor location. The majority of low-grade gliomas reveal mutations in the genes encoding isocitrate-dehydrogenase 1 ( IDH1 ) or 2 ( IDH2 ). These mutation...

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