Is there any association between GLY82 ser polymorphism of rage gene and Turkish diabetic and non diabetic patients with coronary artery disease?
This study was carried out in 52 non-diabetic, 62 diabetic patients with coronary artery disease (CAD) and 55 controls. A Gly to Ser change RAGE gene was analyzed by PCR-RFLP techniques. GlyGly genotype frequency is higher in non-diabetics versus controls ( P non-diabetics. These results reveals n...
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| Veröffentlicht in: | Molecular biology reports 2012-04, Vol.39 (4), p.4423-4428 |
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| creator | Kucukhuseyin, Ozlem Yilmaz-Aydogan, Hulya Isbir, C. Selim Isbir, Turgay |
| description | This study was carried out in 52 non-diabetic, 62 diabetic patients with coronary artery disease (CAD) and 55 controls. A Gly to Ser change RAGE gene was analyzed by PCR-RFLP techniques. GlyGly genotype frequency is higher in non-diabetics versus controls (
P
non-diabetics. These results reveals none association between Gly82Ser and the development of disease in non-diabetic patients. In diabetics with Ser allele, higher prevalence of left-ventricule-hypertrophy was observed, but the significant difference between Gly82Ser and left-ventricule-hypertrophy only found in the whole patient group. As a result Ser allele has much more importance in the development of left-ventricule-hypertrophy than other cardiovascular risk factors. In this study we found the presence of Gly allele contributes to the CAD in non-diabetics and Ser allele may contribute to disease in diabetics. |
| doi_str_mv | 10.1007/s11033-011-1230-3 |
| format | Article |
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P
< 0.001). GlySer frequency is higher in diabetics than controls and non-diabetics (
P
< 0.001). Ser allele frequency is respectively increased in the order of diabetics > Controls > non-diabetics. These results reveals none association between Gly82Ser and the development of disease in non-diabetic patients. In diabetics with Ser allele, higher prevalence of left-ventricule-hypertrophy was observed, but the significant difference between Gly82Ser and left-ventricule-hypertrophy only found in the whole patient group. As a result Ser allele has much more importance in the development of left-ventricule-hypertrophy than other cardiovascular risk factors. In this study we found the presence of Gly allele contributes to the CAD in non-diabetics and Ser allele may contribute to disease in diabetics.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-011-1230-3</identifier><identifier>PMID: 21947881</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animal Anatomy ; Animal Biochemistry ; Biomedical and Life Sciences ; Cardiovascular disease ; Coronary Artery Disease - complications ; Coronary Artery Disease - genetics ; Demography ; Diabetes ; Diabetes Complications - genetics ; Female ; Gene Frequency - genetics ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype & phenotype ; Glycine - genetics ; Histology ; Humans ; Life Sciences ; Male ; Middle Aged ; Morphology ; Polymorphism ; Polymorphism, Single Nucleotide - genetics ; Population genetics ; Receptor for Advanced Glycation End Products ; Receptors, Immunologic - genetics ; Risk Factors ; Serine - genetics ; Turkey</subject><ispartof>Molecular biology reports, 2012-04, Vol.39 (4), p.4423-4428</ispartof><rights>Springer Science+Business Media B.V. 2011</rights><rights>Springer Science+Business Media B.V. 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-d923c47015700927be926efa5dee5231f7933495dde274b58a897ae463d9d30f3</citedby><cites>FETCH-LOGICAL-c370t-d923c47015700927be926efa5dee5231f7933495dde274b58a897ae463d9d30f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-011-1230-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-011-1230-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21947881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kucukhuseyin, Ozlem</creatorcontrib><creatorcontrib>Yilmaz-Aydogan, Hulya</creatorcontrib><creatorcontrib>Isbir, C. Selim</creatorcontrib><creatorcontrib>Isbir, Turgay</creatorcontrib><title>Is there any association between GLY82 ser polymorphism of rage gene and Turkish diabetic and non diabetic patients with coronary artery disease?</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>This study was carried out in 52 non-diabetic, 62 diabetic patients with coronary artery disease (CAD) and 55 controls. A Gly to Ser change RAGE gene was analyzed by PCR-RFLP techniques. GlyGly genotype frequency is higher in non-diabetics versus controls (
P
< 0.001). GlySer frequency is higher in diabetics than controls and non-diabetics (
P
< 0.001). Ser allele frequency is respectively increased in the order of diabetics > Controls > non-diabetics. These results reveals none association between Gly82Ser and the development of disease in non-diabetic patients. In diabetics with Ser allele, higher prevalence of left-ventricule-hypertrophy was observed, but the significant difference between Gly82Ser and left-ventricule-hypertrophy only found in the whole patient group. As a result Ser allele has much more importance in the development of left-ventricule-hypertrophy than other cardiovascular risk factors. In this study we found the presence of Gly allele contributes to the CAD in non-diabetics and Ser allele may contribute to disease in diabetics.</description><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cardiovascular disease</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - genetics</subject><subject>Demography</subject><subject>Diabetes</subject><subject>Diabetes Complications - genetics</subject><subject>Female</subject><subject>Gene Frequency - genetics</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype & phenotype</subject><subject>Glycine - genetics</subject><subject>Histology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Population genetics</subject><subject>Receptor for Advanced Glycation End Products</subject><subject>Receptors, Immunologic - genetics</subject><subject>Risk Factors</subject><subject>Serine - genetics</subject><subject>Turkey</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc9u1DAQxi0EokvLA3BBFhdOof6XtX1CqIJSaaVeyqEnyxtPdl02dvAkqvoYvDEOW4qExGmkmd_3zYw-Qt5w9oEzps-RcyZlwzhvuJCskc_IirdaNspq85ysmGS8UablJ-QV4h1jTHHdviQngluljeEr8vMK6bSHAtSnB-oRcxf9FHOiW5juARK93NwaQREKHfPhYchl3EccaO5p8TugO0iLNtCbuXyPuKch-iqN3e9mqkZPjbEaQ5qQ3sdpT7tccvKlLi0T1BIigkf4eEZe9P6A8PqxnpJvXz7fXHxtNteXVxefNk0nNZuaYIXslGb1X8as0FuwYg29bwNAKyTvtZVS2TYEEFptW-ON1R7UWgYbJOvlKXl_9B1L_jEDTm6I2MHh4BPkGV21Wyu1NqqS7_4h7_JcUj1ugaRShi8QP0JdyYgFejeWONT_HGduScsd03I1Lbek5WTVvH00nrcDhCfFn3gqII4A1lHaQfm7-f-uvwCwxaA6</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Kucukhuseyin, Ozlem</creator><creator>Yilmaz-Aydogan, Hulya</creator><creator>Isbir, C. 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Selim ; Isbir, Turgay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-d923c47015700927be926efa5dee5231f7933495dde274b58a897ae463d9d30f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cardiovascular disease</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - genetics</topic><topic>Demography</topic><topic>Diabetes</topic><topic>Diabetes Complications - genetics</topic><topic>Female</topic><topic>Gene Frequency - genetics</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype & phenotype</topic><topic>Glycine - genetics</topic><topic>Histology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Morphology</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Population genetics</topic><topic>Receptor for Advanced Glycation End Products</topic><topic>Receptors, Immunologic - genetics</topic><topic>Risk Factors</topic><topic>Serine - genetics</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kucukhuseyin, Ozlem</creatorcontrib><creatorcontrib>Yilmaz-Aydogan, Hulya</creatorcontrib><creatorcontrib>Isbir, C. 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Selim</au><au>Isbir, Turgay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is there any association between GLY82 ser polymorphism of rage gene and Turkish diabetic and non diabetic patients with coronary artery disease?</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>39</volume><issue>4</issue><spage>4423</spage><epage>4428</epage><pages>4423-4428</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>This study was carried out in 52 non-diabetic, 62 diabetic patients with coronary artery disease (CAD) and 55 controls. A Gly to Ser change RAGE gene was analyzed by PCR-RFLP techniques. GlyGly genotype frequency is higher in non-diabetics versus controls (
P
< 0.001). GlySer frequency is higher in diabetics than controls and non-diabetics (
P
< 0.001). Ser allele frequency is respectively increased in the order of diabetics > Controls > non-diabetics. These results reveals none association between Gly82Ser and the development of disease in non-diabetic patients. In diabetics with Ser allele, higher prevalence of left-ventricule-hypertrophy was observed, but the significant difference between Gly82Ser and left-ventricule-hypertrophy only found in the whole patient group. As a result Ser allele has much more importance in the development of left-ventricule-hypertrophy than other cardiovascular risk factors. In this study we found the presence of Gly allele contributes to the CAD in non-diabetics and Ser allele may contribute to disease in diabetics.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>21947881</pmid><doi>10.1007/s11033-011-1230-3</doi><tpages>6</tpages></addata></record> |
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| ispartof | Molecular biology reports, 2012-04, Vol.39 (4), p.4423-4428 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animal Anatomy Animal Biochemistry Biomedical and Life Sciences Cardiovascular disease Coronary Artery Disease - complications Coronary Artery Disease - genetics Demography Diabetes Diabetes Complications - genetics Female Gene Frequency - genetics Genetic Association Studies Genetic Predisposition to Disease Genotype & phenotype Glycine - genetics Histology Humans Life Sciences Male Middle Aged Morphology Polymorphism Polymorphism, Single Nucleotide - genetics Population genetics Receptor for Advanced Glycation End Products Receptors, Immunologic - genetics Risk Factors Serine - genetics Turkey |
| title | Is there any association between GLY82 ser polymorphism of rage gene and Turkish diabetic and non diabetic patients with coronary artery disease? |
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