Associations of polymorphisms of folate cycle enzymes and risk of breast cancer in a Brazilian population are age dependent
Polymorphisms in genes involved in folate metabolism have been shown to be implicated in breast cancer risk but with contradictory results. In this case–control study, we investigated the association between MTHFR C677T and A1298C, TYMS 5′-UTR, MTR A2756G and c SHMT C1420T and also the folate carrie...
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| Veröffentlicht in: | Molecular biology reports 2012-04, Vol.39 (4), p.4899-4907 |
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| description | Polymorphisms in genes involved in folate metabolism have been shown to be implicated in breast cancer risk but with contradictory results. In this case–control study, we investigated the association between
MTHFR
C677T and A1298C, TYMS 5′-UTR,
MTR
A2756G and c
SHMT
C1420T and also the folate carrier (
RFC1
G80A) and breast cancer risk in a northeastern Brazilian population. The study included 183 women diagnosed with breast cancer and 183 controls volunteers without any history of cancer. Also a significant number of healthy individuals were included for allelic frequency in the population studied. Risk of breast cancer was estimated by conditional logistic regression. An association with risk was found for women carrying the
MTR
A2756G polymorphic allele (AG,
P
= 0.0036; AG/GG,
P
= 0.0040), and a protective effect in carriers of the
RFC1
G80A polymorphic allele (GA,
P
= 0.0015; AA,
P
= 0.0042). Stratifying the data by age (cutoff point of 50 years old), different distributions were observed for breast cancer risk. For women ≤50 years, the risk observed in the presence of the polymorphic allele
MTR
2756 (AG/GG) in the general analysis was, restricted to this age group (
P
= 0.0118). Conversely, for women over 50, the risk of breast cancer development was statistically associated with the
MTHFR
677CT genotype, but especially significant was risk associated with the presence of the polymorphic allele of
cSHMT
C1420T (
P
= 0.0120) and the protective effect associated with the
RFC1
G80A polymorphism allele (
P
= 0.0021), was restrict to this age group. These data indicate that the cutoff age used (50 years old) was appropriate, since it was able to discriminate risk in each age group in the population studied and also to point to the importance of age in the analyses of cancer-associated polymorphisms. |
| doi_str_mv | 10.1007/s11033-011-1285-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_926644620</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2602651811</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-d799639c2c217f74efe280700f1cafcf496e0017e0b690182006335a6de62d6b3</originalsourceid><addsrcrecordid>eNp1kU1v1DAQQC0EokvhB3BBFhdOgRk7sZNjqfiSKnGBs-V1xsUlsYOdHLb8ebzdAhISJ0v2mzeWHmPPEV4jgH5TEEHKBhAbFH3X4AO2w07Lph10_5DtQAI2bd_hGXtSyg0AtKi7x-xMCJSt7sSO_bwoJblg15Bi4cnzJU2HOeXlWyjz3YVPk12Ju4ObiFO8PcxUuI0jz6F8PwL7TLas3NnoKPMQueVvs70NU7Cx6pZturNzm4nba-IjLRRHiutT9sjbqdCz-_OcfX3_7svlx-bq84dPlxdXjZMa1mbUw6Dk4IQTqL1uyZPoQQN4dNY73w6KAFAT7NUA2AsAJWVn1UhKjGovz9mrk3fJ6cdGZTVzKI6myUZKWzGDUKptlYBKvvyHvElbjvVzR0i2ddVQITxBLqdSMnmz5DDbfDAI5tjFnLqY2sUcuxisMy_uxdt-pvHPxO8QFRAnoNSneE357-b_W38BFMaYkg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>926344969</pqid></control><display><type>article</type><title>Associations of polymorphisms of folate cycle enzymes and risk of breast cancer in a Brazilian population are age dependent</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Carvalho Barbosa, Rita de Cássia ; Menezes, Débora Costa ; Freire, Thiago Fernando Vasconcelos ; Sales, Diogo Campos ; Alencar, Victor Hugo Medeiros ; Rabenhorst, Silvia Helena Barem</creator><creatorcontrib>Carvalho Barbosa, Rita de Cássia ; Menezes, Débora Costa ; Freire, Thiago Fernando Vasconcelos ; Sales, Diogo Campos ; Alencar, Victor Hugo Medeiros ; Rabenhorst, Silvia Helena Barem</creatorcontrib><description>Polymorphisms in genes involved in folate metabolism have been shown to be implicated in breast cancer risk but with contradictory results. In this case–control study, we investigated the association between
MTHFR
C677T and A1298C, TYMS 5′-UTR,
MTR
A2756G and c
SHMT
C1420T and also the folate carrier (
RFC1
G80A) and breast cancer risk in a northeastern Brazilian population. The study included 183 women diagnosed with breast cancer and 183 controls volunteers without any history of cancer. Also a significant number of healthy individuals were included for allelic frequency in the population studied. Risk of breast cancer was estimated by conditional logistic regression. An association with risk was found for women carrying the
MTR
A2756G polymorphic allele (AG,
P
= 0.0036; AG/GG,
P
= 0.0040), and a protective effect in carriers of the
RFC1
G80A polymorphic allele (GA,
P
= 0.0015; AA,
P
= 0.0042). Stratifying the data by age (cutoff point of 50 years old), different distributions were observed for breast cancer risk. For women ≤50 years, the risk observed in the presence of the polymorphic allele
MTR
2756 (AG/GG) in the general analysis was, restricted to this age group (
P
= 0.0118). Conversely, for women over 50, the risk of breast cancer development was statistically associated with the
MTHFR
677CT genotype, but especially significant was risk associated with the presence of the polymorphic allele of
cSHMT
C1420T (
P
= 0.0120) and the protective effect associated with the
RFC1
G80A polymorphism allele (
P
= 0.0021), was restrict to this age group. These data indicate that the cutoff age used (50 years old) was appropriate, since it was able to discriminate risk in each age group in the population studied and also to point to the importance of age in the analyses of cancer-associated polymorphisms.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-011-1285-1</identifier><identifier>PMID: 22134752</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>5' Untranslated Regions - genetics ; Adult ; Aged ; Aging - pathology ; Animal Anatomy ; Animal Biochemistry ; Biomedical and Life Sciences ; Brazil ; Breast cancer ; Breast Neoplasms - enzymology ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Enzymes ; Female ; Folic Acid - metabolism ; Gene Frequency - genetics ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genetics, Population ; Genotype & phenotype ; Histology ; Humans ; Life Sciences ; Metabolism ; Middle Aged ; Morphology ; Neoplasm Staging ; Polymerase Chain Reaction ; Polymorphism ; Polymorphism, Single Nucleotide - genetics ; Risk Factors ; Vitamin B</subject><ispartof>Molecular biology reports, 2012-04, Vol.39 (4), p.4899-4907</ispartof><rights>Springer Science+Business Media B.V. 2011</rights><rights>Springer Science+Business Media B.V. 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-d799639c2c217f74efe280700f1cafcf496e0017e0b690182006335a6de62d6b3</citedby><cites>FETCH-LOGICAL-c370t-d799639c2c217f74efe280700f1cafcf496e0017e0b690182006335a6de62d6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-011-1285-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-011-1285-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22134752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carvalho Barbosa, Rita de Cássia</creatorcontrib><creatorcontrib>Menezes, Débora Costa</creatorcontrib><creatorcontrib>Freire, Thiago Fernando Vasconcelos</creatorcontrib><creatorcontrib>Sales, Diogo Campos</creatorcontrib><creatorcontrib>Alencar, Victor Hugo Medeiros</creatorcontrib><creatorcontrib>Rabenhorst, Silvia Helena Barem</creatorcontrib><title>Associations of polymorphisms of folate cycle enzymes and risk of breast cancer in a Brazilian population are age dependent</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Polymorphisms in genes involved in folate metabolism have been shown to be implicated in breast cancer risk but with contradictory results. In this case–control study, we investigated the association between
MTHFR
C677T and A1298C, TYMS 5′-UTR,
MTR
A2756G and c
SHMT
C1420T and also the folate carrier (
RFC1
G80A) and breast cancer risk in a northeastern Brazilian population. The study included 183 women diagnosed with breast cancer and 183 controls volunteers without any history of cancer. Also a significant number of healthy individuals were included for allelic frequency in the population studied. Risk of breast cancer was estimated by conditional logistic regression. An association with risk was found for women carrying the
MTR
A2756G polymorphic allele (AG,
P
= 0.0036; AG/GG,
P
= 0.0040), and a protective effect in carriers of the
RFC1
G80A polymorphic allele (GA,
P
= 0.0015; AA,
P
= 0.0042). Stratifying the data by age (cutoff point of 50 years old), different distributions were observed for breast cancer risk. For women ≤50 years, the risk observed in the presence of the polymorphic allele
MTR
2756 (AG/GG) in the general analysis was, restricted to this age group (
P
= 0.0118). Conversely, for women over 50, the risk of breast cancer development was statistically associated with the
MTHFR
677CT genotype, but especially significant was risk associated with the presence of the polymorphic allele of
cSHMT
C1420T (
P
= 0.0120) and the protective effect associated with the
RFC1
G80A polymorphism allele (
P
= 0.0021), was restrict to this age group. These data indicate that the cutoff age used (50 years old) was appropriate, since it was able to discriminate risk in each age group in the population studied and also to point to the importance of age in the analyses of cancer-associated polymorphisms.</description><subject>5' Untranslated Regions - genetics</subject><subject>Adult</subject><subject>Aged</subject><subject>Aging - pathology</subject><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Brazil</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - enzymology</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Enzymes</subject><subject>Female</subject><subject>Folic Acid - metabolism</subject><subject>Gene Frequency - genetics</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics, Population</subject><subject>Genotype & phenotype</subject><subject>Histology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Neoplasm Staging</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Risk Factors</subject><subject>Vitamin B</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1v1DAQQC0EokvhB3BBFhdOgRk7sZNjqfiSKnGBs-V1xsUlsYOdHLb8ebzdAhISJ0v2mzeWHmPPEV4jgH5TEEHKBhAbFH3X4AO2w07Lph10_5DtQAI2bd_hGXtSyg0AtKi7x-xMCJSt7sSO_bwoJblg15Bi4cnzJU2HOeXlWyjz3YVPk12Ju4ObiFO8PcxUuI0jz6F8PwL7TLas3NnoKPMQueVvs70NU7Cx6pZturNzm4nba-IjLRRHiutT9sjbqdCz-_OcfX3_7svlx-bq84dPlxdXjZMa1mbUw6Dk4IQTqL1uyZPoQQN4dNY73w6KAFAT7NUA2AsAJWVn1UhKjGovz9mrk3fJ6cdGZTVzKI6myUZKWzGDUKptlYBKvvyHvElbjvVzR0i2ddVQITxBLqdSMnmz5DDbfDAI5tjFnLqY2sUcuxisMy_uxdt-pvHPxO8QFRAnoNSneE357-b_W38BFMaYkg</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Carvalho Barbosa, Rita de Cássia</creator><creator>Menezes, Débora Costa</creator><creator>Freire, Thiago Fernando Vasconcelos</creator><creator>Sales, Diogo Campos</creator><creator>Alencar, Victor Hugo Medeiros</creator><creator>Rabenhorst, Silvia Helena Barem</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20120401</creationdate><title>Associations of polymorphisms of folate cycle enzymes and risk of breast cancer in a Brazilian population are age dependent</title><author>Carvalho Barbosa, Rita de Cássia ; Menezes, Débora Costa ; Freire, Thiago Fernando Vasconcelos ; Sales, Diogo Campos ; Alencar, Victor Hugo Medeiros ; Rabenhorst, Silvia Helena Barem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-d799639c2c217f74efe280700f1cafcf496e0017e0b690182006335a6de62d6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>5' Untranslated Regions - genetics</topic><topic>Adult</topic><topic>Aged</topic><topic>Aging - pathology</topic><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Brazil</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - enzymology</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Enzymes</topic><topic>Female</topic><topic>Folic Acid - metabolism</topic><topic>Gene Frequency - genetics</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics, Population</topic><topic>Genotype & phenotype</topic><topic>Histology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Morphology</topic><topic>Neoplasm Staging</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Risk Factors</topic><topic>Vitamin B</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carvalho Barbosa, Rita de Cássia</creatorcontrib><creatorcontrib>Menezes, Débora Costa</creatorcontrib><creatorcontrib>Freire, Thiago Fernando Vasconcelos</creatorcontrib><creatorcontrib>Sales, Diogo Campos</creatorcontrib><creatorcontrib>Alencar, Victor Hugo Medeiros</creatorcontrib><creatorcontrib>Rabenhorst, Silvia Helena Barem</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carvalho Barbosa, Rita de Cássia</au><au>Menezes, Débora Costa</au><au>Freire, Thiago Fernando Vasconcelos</au><au>Sales, Diogo Campos</au><au>Alencar, Victor Hugo Medeiros</au><au>Rabenhorst, Silvia Helena Barem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of polymorphisms of folate cycle enzymes and risk of breast cancer in a Brazilian population are age dependent</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>39</volume><issue>4</issue><spage>4899</spage><epage>4907</epage><pages>4899-4907</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>Polymorphisms in genes involved in folate metabolism have been shown to be implicated in breast cancer risk but with contradictory results. In this case–control study, we investigated the association between
MTHFR
C677T and A1298C, TYMS 5′-UTR,
MTR
A2756G and c
SHMT
C1420T and also the folate carrier (
RFC1
G80A) and breast cancer risk in a northeastern Brazilian population. The study included 183 women diagnosed with breast cancer and 183 controls volunteers without any history of cancer. Also a significant number of healthy individuals were included for allelic frequency in the population studied. Risk of breast cancer was estimated by conditional logistic regression. An association with risk was found for women carrying the
MTR
A2756G polymorphic allele (AG,
P
= 0.0036; AG/GG,
P
= 0.0040), and a protective effect in carriers of the
RFC1
G80A polymorphic allele (GA,
P
= 0.0015; AA,
P
= 0.0042). Stratifying the data by age (cutoff point of 50 years old), different distributions were observed for breast cancer risk. For women ≤50 years, the risk observed in the presence of the polymorphic allele
MTR
2756 (AG/GG) in the general analysis was, restricted to this age group (
P
= 0.0118). Conversely, for women over 50, the risk of breast cancer development was statistically associated with the
MTHFR
677CT genotype, but especially significant was risk associated with the presence of the polymorphic allele of
cSHMT
C1420T (
P
= 0.0120) and the protective effect associated with the
RFC1
G80A polymorphism allele (
P
= 0.0021), was restrict to this age group. These data indicate that the cutoff age used (50 years old) was appropriate, since it was able to discriminate risk in each age group in the population studied and also to point to the importance of age in the analyses of cancer-associated polymorphisms.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>22134752</pmid><doi>10.1007/s11033-011-1285-1</doi><tpages>9</tpages></addata></record> |
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| ispartof | Molecular biology reports, 2012-04, Vol.39 (4), p.4899-4907 |
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| subjects | 5' Untranslated Regions - genetics Adult Aged Aging - pathology Animal Anatomy Animal Biochemistry Biomedical and Life Sciences Brazil Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - genetics Breast Neoplasms - pathology Enzymes Female Folic Acid - metabolism Gene Frequency - genetics Genetic Association Studies Genetic Predisposition to Disease Genetics, Population Genotype & phenotype Histology Humans Life Sciences Metabolism Middle Aged Morphology Neoplasm Staging Polymerase Chain Reaction Polymorphism Polymorphism, Single Nucleotide - genetics Risk Factors Vitamin B |
| title | Associations of polymorphisms of folate cycle enzymes and risk of breast cancer in a Brazilian population are age dependent |
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