Metabolic network analysis revealed distinct routes of deletion effects between essential and non-essential genes

Interest in essential genes has arisen recently given their importance in antimicrobial drug development. Although knockouts of essential genes are commonly known to cause lethal phenotypes, there is insufficient understanding on the intermediate changes followed by genetic perturbation and to what...

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Veröffentlicht in:	Molecular bioSystems 2012-04, Vol.8 (4), p.1179-1186
Hauptverfasser:	Ma, Jing, Zhang, Xun, Ung, Choong Yong, Chen, Yu Zong, Li, Baowen
Format:	Artikel
Sprache:	eng
Schlagworte:	Escherichia Escherichia coli - genetics Escherichia coli - metabolism Gene Deletion Gene Knockout Techniques Genes, Bacterial Genes, Essential Genes, Fungal Metabolic Networks and Pathways - genetics Models, Genetic Phenotype Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism
Online-Zugang:	Volltext
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