Transcriptomic profiling of astrocytes treated with the Rho kinase inhibitor Fasudil reveals cytoskeletal and pro-survival responses

Inhibitors of Rho kinase (ROCK) have potential for management of neurological disorders by inhibition of glial scarring. Since astrocytes play key roles in brain physiology and pathology, we determined changes in the astrocytic transcriptome produced by the ROCK inhibitor Fasudil to obtain mechanist...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of cellular physiology 2012-03, Vol.227 (3), p.1199-1211
Hauptverfasser:	Lau, Chew L., Perreau, Victoria M., Chen, Minghui J., Cate, Holly S., Merlo, Daniel, Cheung, Nam S., O'Shea, Ross D., Beart, Philip M.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology Animals Astrocytes - cytology Astrocytes - drug effects Astrocytes - enzymology Gene Expression Profiling - methods Mice Mice, Inbred C57BL Primary Cell Culture Protein Kinase Inhibitors - pharmacology rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - genetics Transcriptome - drug effects Transcriptome - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!