Immunomodulatory and antioxidant effects of carboxymethylpachymaran on the mice infected with PCV2
The objective of the current study is to investigate the protective effect of carboxymethylpachymaran (CMP) on the immune system of mice via multiple infections with porcine circovirus type 2 (PCV2). The in vivo results showed that CMP administration significantly improved the spleen or thymus index...
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| Veröffentlicht in: | International journal of biological macromolecules 2012-04, Vol.50 (3), p.713-719 |
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| container_title | International journal of biological macromolecules |
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| creator | Wei, Ying-Yi Hu, Ting-Jun Su, Zi-Jie Zeng, Yun Wei, Xiao-Jie Zhang, Shu-Xia |
| description | The objective of the current study is to investigate the protective effect of carboxymethylpachymaran (CMP) on the immune system of mice via multiple infections with porcine circovirus type 2 (PCV2). The in vivo results showed that CMP administration significantly improved the spleen or thymus index, promoted the proliferation activities of T or B lymphocytes, and increased the production of glutathione, the superoxidase dismutase capacity, and the total antioxidant capacity in the spleen or thymus of PCV2-infected mice. The administration of different CMP doses to PVC2-inoculated mice resulted in the upregulation of IL-2 and IFN-α or the downregulation of IL-10 levels in the serum. These findings suggest that CMP has potential applications in regulating immunological functions to overcome the immunosuppresion caused by PCV2 infection in mice. The findings may also prove useful in designing effective therapies against PCV2 infection. |
| doi_str_mv | 10.1016/j.ijbiomac.2011.12.024 |
| format | Article |
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The in vivo results showed that CMP administration significantly improved the spleen or thymus index, promoted the proliferation activities of T or B lymphocytes, and increased the production of glutathione, the superoxidase dismutase capacity, and the total antioxidant capacity in the spleen or thymus of PCV2-infected mice. The administration of different CMP doses to PVC2-inoculated mice resulted in the upregulation of IL-2 and IFN-α or the downregulation of IL-10 levels in the serum. These findings suggest that CMP has potential applications in regulating immunological functions to overcome the immunosuppresion caused by PCV2 infection in mice. The findings may also prove useful in designing effective therapies against PCV2 infection.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2011.12.024</identifier><identifier>PMID: 22214825</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; antioxidant activity ; Antioxidants ; Antioxidants - pharmacology ; B-lymphocytes ; blood serum ; Carboxymethylpachymaran ; Cell Line ; Cell Proliferation - drug effects ; Circoviridae Infections - blood ; Circoviridae Infections - enzymology ; Circoviridae Infections - immunology ; Circoviridae Infections - metabolism ; Circovirus - pathogenicity ; Cytokines ; Cytokines - blood ; Female ; Glucans - pharmacology ; Glutathione ; Glutathione - biosynthesis ; Immune system ; Immune Tolerance - drug effects ; Immunologic Factors - pharmacology ; Immunomodulation ; Infection ; interferon-alpha ; Interleukin 10 ; Interleukin 2 ; Lymphocytes - cytology ; Lymphocytes - drug effects ; Lymphocytes B ; Macromolecules ; Male ; Mice ; PCV2 ; Porcine circovirus ; Porcine circovirus-2 ; Proliferation ; protective effect ; Spleen ; Spleen - cytology ; Spleen - drug effects ; Spleen - metabolism ; Superoxide Dismutase - metabolism ; Thymus ; thymus gland ; Thymus Gland - cytology ; Thymus Gland - drug effects ; Thymus Gland - metabolism</subject><ispartof>International journal of biological macromolecules, 2012-04, Vol.50 (3), p.713-719</ispartof><rights>2011 Elsevier B.V.</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-71be6710276642540a23b4f9daccf916cdd9489b31b75c97b971d3960e176eb63</citedby><cites>FETCH-LOGICAL-c424t-71be6710276642540a23b4f9daccf916cdd9489b31b75c97b971d3960e176eb63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijbiomac.2011.12.024$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22214825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wei, Ying-Yi</creatorcontrib><creatorcontrib>Hu, Ting-Jun</creatorcontrib><creatorcontrib>Su, Zi-Jie</creatorcontrib><creatorcontrib>Zeng, Yun</creatorcontrib><creatorcontrib>Wei, Xiao-Jie</creatorcontrib><creatorcontrib>Zhang, Shu-Xia</creatorcontrib><title>Immunomodulatory and antioxidant effects of carboxymethylpachymaran on the mice infected with PCV2</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>The objective of the current study is to investigate the protective effect of carboxymethylpachymaran (CMP) on the immune system of mice via multiple infections with porcine circovirus type 2 (PCV2). The in vivo results showed that CMP administration significantly improved the spleen or thymus index, promoted the proliferation activities of T or B lymphocytes, and increased the production of glutathione, the superoxidase dismutase capacity, and the total antioxidant capacity in the spleen or thymus of PCV2-infected mice. The administration of different CMP doses to PVC2-inoculated mice resulted in the upregulation of IL-2 and IFN-α or the downregulation of IL-10 levels in the serum. These findings suggest that CMP has potential applications in regulating immunological functions to overcome the immunosuppresion caused by PCV2 infection in mice. The findings may also prove useful in designing effective therapies against PCV2 infection.</description><subject>Animals</subject><subject>antioxidant activity</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>B-lymphocytes</subject><subject>blood serum</subject><subject>Carboxymethylpachymaran</subject><subject>Cell Line</subject><subject>Cell Proliferation - drug effects</subject><subject>Circoviridae Infections - blood</subject><subject>Circoviridae Infections - enzymology</subject><subject>Circoviridae Infections - immunology</subject><subject>Circoviridae Infections - metabolism</subject><subject>Circovirus - pathogenicity</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Female</subject><subject>Glucans - pharmacology</subject><subject>Glutathione</subject><subject>Glutathione - biosynthesis</subject><subject>Immune system</subject><subject>Immune Tolerance - drug effects</subject><subject>Immunologic Factors - pharmacology</subject><subject>Immunomodulation</subject><subject>Infection</subject><subject>interferon-alpha</subject><subject>Interleukin 10</subject><subject>Interleukin 2</subject><subject>Lymphocytes - cytology</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes B</subject><subject>Macromolecules</subject><subject>Male</subject><subject>Mice</subject><subject>PCV2</subject><subject>Porcine circovirus</subject><subject>Porcine circovirus-2</subject><subject>Proliferation</subject><subject>protective effect</subject><subject>Spleen</subject><subject>Spleen - cytology</subject><subject>Spleen - drug effects</subject><subject>Spleen - metabolism</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Thymus</subject><subject>thymus gland</subject><subject>Thymus Gland - cytology</subject><subject>Thymus Gland - drug effects</subject><subject>Thymus Gland - metabolism</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhLxTf4JLgcRw7voFWfFSqBBKUq-WvsF4l8WIn0Px7HG3LEQ7WSNYz78y8L0JXQGogwN8c63A0IY7a1pQA1EBrQtkjtINOyIoQ0jxGOwIMqg4acoGe5Xwsv7yF7im6oJQC62i7Q-Z6HJcpjtEtg55jWrGeXHlziHfBlYp933s7Zxx7bHUy8W4d_XxYh5O2h3XUSU84Tng-eDwG63GYNtw7_DvMB_xl_50-R096PWT_4r5eotsP77_tP1U3nz9e79_dVJZRNlcCjOcCCBWcM9oyomljWC-dtraXwK1zknXSNGBEa6UwUoBrJCceBPeGN5fo1Vn3lOLPxedZjSFbPwx68nHJStJNWIi2kK__SQKRDRPQka6g_IzaFHNOvlenFMrVa4HUloQ6qock1JaEAqpKEqXx6n7GYkbv_rY9WF-Al2eg11HpHylkdfu1KPASU9uJdiPenglfXPsVfFLZBj9Z70IqHisXw_-2-AOS4aaq</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Wei, Ying-Yi</creator><creator>Hu, Ting-Jun</creator><creator>Su, Zi-Jie</creator><creator>Zeng, Yun</creator><creator>Wei, Xiao-Jie</creator><creator>Zhang, Shu-Xia</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20120401</creationdate><title>Immunomodulatory and antioxidant effects of carboxymethylpachymaran on the mice infected with PCV2</title><author>Wei, Ying-Yi ; Hu, Ting-Jun ; Su, Zi-Jie ; Zeng, Yun ; Wei, Xiao-Jie ; Zhang, Shu-Xia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-71be6710276642540a23b4f9daccf916cdd9489b31b75c97b971d3960e176eb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>antioxidant activity</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>B-lymphocytes</topic><topic>blood serum</topic><topic>Carboxymethylpachymaran</topic><topic>Cell Line</topic><topic>Cell Proliferation - drug effects</topic><topic>Circoviridae Infections - blood</topic><topic>Circoviridae Infections - enzymology</topic><topic>Circoviridae Infections - immunology</topic><topic>Circoviridae Infections - metabolism</topic><topic>Circovirus - pathogenicity</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Female</topic><topic>Glucans - pharmacology</topic><topic>Glutathione</topic><topic>Glutathione - biosynthesis</topic><topic>Immune system</topic><topic>Immune Tolerance - drug effects</topic><topic>Immunologic Factors - pharmacology</topic><topic>Immunomodulation</topic><topic>Infection</topic><topic>interferon-alpha</topic><topic>Interleukin 10</topic><topic>Interleukin 2</topic><topic>Lymphocytes - cytology</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes B</topic><topic>Macromolecules</topic><topic>Male</topic><topic>Mice</topic><topic>PCV2</topic><topic>Porcine circovirus</topic><topic>Porcine circovirus-2</topic><topic>Proliferation</topic><topic>protective effect</topic><topic>Spleen</topic><topic>Spleen - cytology</topic><topic>Spleen - drug effects</topic><topic>Spleen - metabolism</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Thymus</topic><topic>thymus gland</topic><topic>Thymus Gland - cytology</topic><topic>Thymus Gland - drug effects</topic><topic>Thymus Gland - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Ying-Yi</creatorcontrib><creatorcontrib>Hu, Ting-Jun</creatorcontrib><creatorcontrib>Su, Zi-Jie</creatorcontrib><creatorcontrib>Zeng, Yun</creatorcontrib><creatorcontrib>Wei, Xiao-Jie</creatorcontrib><creatorcontrib>Zhang, Shu-Xia</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Ying-Yi</au><au>Hu, Ting-Jun</au><au>Su, Zi-Jie</au><au>Zeng, Yun</au><au>Wei, Xiao-Jie</au><au>Zhang, Shu-Xia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunomodulatory and antioxidant effects of carboxymethylpachymaran on the mice infected with PCV2</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>50</volume><issue>3</issue><spage>713</spage><epage>719</epage><pages>713-719</pages><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>The objective of the current study is to investigate the protective effect of carboxymethylpachymaran (CMP) on the immune system of mice via multiple infections with porcine circovirus type 2 (PCV2). The in vivo results showed that CMP administration significantly improved the spleen or thymus index, promoted the proliferation activities of T or B lymphocytes, and increased the production of glutathione, the superoxidase dismutase capacity, and the total antioxidant capacity in the spleen or thymus of PCV2-infected mice. The administration of different CMP doses to PVC2-inoculated mice resulted in the upregulation of IL-2 and IFN-α or the downregulation of IL-10 levels in the serum. These findings suggest that CMP has potential applications in regulating immunological functions to overcome the immunosuppresion caused by PCV2 infection in mice. The findings may also prove useful in designing effective therapies against PCV2 infection.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>22214825</pmid><doi>10.1016/j.ijbiomac.2011.12.024</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals antioxidant activity Antioxidants Antioxidants - pharmacology B-lymphocytes blood serum Carboxymethylpachymaran Cell Line Cell Proliferation - drug effects Circoviridae Infections - blood Circoviridae Infections - enzymology Circoviridae Infections - immunology Circoviridae Infections - metabolism Circovirus - pathogenicity Cytokines Cytokines - blood Female Glucans - pharmacology Glutathione Glutathione - biosynthesis Immune system Immune Tolerance - drug effects Immunologic Factors - pharmacology Immunomodulation Infection interferon-alpha Interleukin 10 Interleukin 2 Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes B Macromolecules Male Mice PCV2 Porcine circovirus Porcine circovirus-2 Proliferation protective effect Spleen Spleen - cytology Spleen - drug effects Spleen - metabolism Superoxide Dismutase - metabolism Thymus thymus gland Thymus Gland - cytology Thymus Gland - drug effects Thymus Gland - metabolism |
| title | Immunomodulatory and antioxidant effects of carboxymethylpachymaran on the mice infected with PCV2 |
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