Effect of CYP3A41G on the fentanyl consumption for intravenous patient-controlled analgesia after total abdominal hysterectomy in Chinese Han population

Summary What is known and Objective: Clinical investigations into postoperative intravenous patient‐controlled analgesia (PCA) have indicated interindividual differences in fentanyl consumption. Cytochrome P450 3A4 (CYP3A4) is the main metabolism enzyme of fentanyl, and single nucleotide polymorphi...

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Veröffentlicht in:	Journal of clinical pharmacy and therapeutics 2012-04, Vol.37 (2), p.153-156
Hauptverfasser:	Dong, Z-L., Li, H., Chen, Q-X., Hu, Y., Wu, S-J., Tang, L-Y., Gong, W-Y., Xie, G-H., Fang, X-M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analgesia, Patient-Controlled - methods Analgesics, Opioid - administration & dosage Analgesics, Opioid - therapeutic use Asian Continental Ancestry Group - genetics Biological and medical sciences China Cytochrome P-450 CYP3A - genetics cytochrome P450 3A4 Female fentanyl Fentanyl - administration & dosage Fentanyl - therapeutic use Humans Hysterectomy - methods Infusions, Intravenous Medical sciences Middle Aged Pain, Postoperative - drug therapy patient-controlled analgesia Pharmacology. Drug treatments Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide single nucleotide polymorphisms Time Factors
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