Effect of CYP3A41G on the fentanyl consumption for intravenous patient-controlled analgesia after total abdominal hysterectomy in Chinese Han population
Summary What is known and Objective: Clinical investigations into postoperative intravenous patient‐controlled analgesia (PCA) have indicated interindividual differences in fentanyl consumption. Cytochrome P450 3A4 (CYP3A4) is the main metabolism enzyme of fentanyl, and single nucleotide polymorphi...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical pharmacy and therapeutics 2012-04, Vol.37 (2), p.153-156 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 156 |
|---|---|
| container_issue | 2 |
| container_start_page | 153 |
| container_title | Journal of clinical pharmacy and therapeutics |
| container_volume | 37 |
| creator | Dong, Z-L. Li, H. Chen, Q-X. Hu, Y. Wu, S-J. Tang, L-Y. Gong, W-Y. Xie, G-H. Fang, X-M. |
| description | Summary
What is known and Objective: Clinical investigations into postoperative intravenous patient‐controlled analgesia (PCA) have indicated interindividual differences in fentanyl consumption. Cytochrome P450 3A4 (CYP3A4) is the main metabolism enzyme of fentanyl, and single nucleotide polymorphisms within the CYP3A4 gene may contribute to the variability of fentanyl analgesic efficacy. The aim of this study was to investigate whether the most common genetic variation in Chinese, CYP3A4*1G, has an impact on the fentanyl consumption for intravenous PCA in Chinese Han women undergone abdominal total hysterectomy.
Methods: A total of 79 female patients (American Society of Anesthesiologist physical status I or II) scheduled to undergo elective abdominal total hysterectomy were enrolled. All patients received combined spinal–epidural anaesthesia with bupivacaine. Intravenous fentanyl PCA was provided postoperatively for satisfactory analgesia. The doses of fentanyl consumption were recorded 2, 4, 24 and 48 h after the initiation of PCA postoperatively. Pain at rest and adverse effects were measured with rating scales. CYP3A4*1G was screened by means of direct sequencing and further confirmed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP).
Results and Discussion: Forty‐six patients were GG homozygotes, 27 patients were GA heterozygotes, and six patients were AA homozygotes, respectively. The distribution of the CYP3A4*1G allele was consistent with Hardy–Weinberg equilibrium (P > 0·05). At 2 and 4 h, the doses of fentanyl required for patients with GA/AA genotypes were 80·0 (45·0, 112·5) μg and 120·0 (80, 173·8) μg, respectively, and significantly lower than those for GG homozygotes [91·3 (80·0, 125·0) μg and 169·0 (112·5, 226·3) μg, respectively, P 0·05).
What is new and Conclusions: CYP3A4*1G has an impact on the analgesic effect of fentanyl in Chinese Han subjects. Further validation of our results in a well‐powered study would be helpful. |
| doi_str_mv | 10.1111/j.1365-2710.2011.01268.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_926642532</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1872836309</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5658-6a0990372697ae96b35135102877fdb60b7cf8d42f2a1606ebe039363ba3e1c13</originalsourceid><addsrcrecordid>eNp9kt-KEzEUxgdR3O7qK0hAxL2Zmj9NMnMjrHVtlUUXXFn0JpyZZmxqJhknGW3fxMc1s60VvDAEEs734zs55MsyRPCUpPViMyVM8JzKVKCYkCkmVBTT7b1schTuZxNMRZnPJJUn2WkIG4yxkJQ9zE4o4YxjQSbZr8um0XVEvkHzz9fsYkYWyDsU1xo12kVwO4tq78LQdtEkofE9Mi728EM7PwTUQTSJyxMTe2-tXiFwYL_qYABBE3WPoo9gEVQr35okofUupHJq6ttd8kLztXE6aLQEhzrfDRbGTo-yBw3YoB8fzrPs05vLm_kyv_qweDu_uMprLniRC8BliZlMk0rQpagYJ2ljWkjZrCqBK1k3xWpGGwpEYKErjVnJBKuAaVITdpY93_t2vf8-6BBVa0KtrQWn04CqpELMKGc0kef_JUkhaZGccZnQp_-gGz_0afiREoLPivTcRD05UEPV6pXqetNCv1N_ficBzw4AhBps04OrTfjLcUFwcce93HM_jdW7o06wGtOiNmoMhRpDoca0qLu0qK16N7--Ga_JIN8bmPQ126MB9N-UkExydft-ob7g5cfb11yoV-w3303B2w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1866548697</pqid></control><display><type>article</type><title>Effect of CYP3A41G on the fentanyl consumption for intravenous patient-controlled analgesia after total abdominal hysterectomy in Chinese Han population</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Dong, Z-L. ; Li, H. ; Chen, Q-X. ; Hu, Y. ; Wu, S-J. ; Tang, L-Y. ; Gong, W-Y. ; Xie, G-H. ; Fang, X-M.</creator><creatorcontrib>Dong, Z-L. ; Li, H. ; Chen, Q-X. ; Hu, Y. ; Wu, S-J. ; Tang, L-Y. ; Gong, W-Y. ; Xie, G-H. ; Fang, X-M.</creatorcontrib><description>Summary
What is known and Objective: Clinical investigations into postoperative intravenous patient‐controlled analgesia (PCA) have indicated interindividual differences in fentanyl consumption. Cytochrome P450 3A4 (CYP3A4) is the main metabolism enzyme of fentanyl, and single nucleotide polymorphisms within the CYP3A4 gene may contribute to the variability of fentanyl analgesic efficacy. The aim of this study was to investigate whether the most common genetic variation in Chinese, CYP3A4*1G, has an impact on the fentanyl consumption for intravenous PCA in Chinese Han women undergone abdominal total hysterectomy.
Methods: A total of 79 female patients (American Society of Anesthesiologist physical status I or II) scheduled to undergo elective abdominal total hysterectomy were enrolled. All patients received combined spinal–epidural anaesthesia with bupivacaine. Intravenous fentanyl PCA was provided postoperatively for satisfactory analgesia. The doses of fentanyl consumption were recorded 2, 4, 24 and 48 h after the initiation of PCA postoperatively. Pain at rest and adverse effects were measured with rating scales. CYP3A4*1G was screened by means of direct sequencing and further confirmed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP).
Results and Discussion: Forty‐six patients were GG homozygotes, 27 patients were GA heterozygotes, and six patients were AA homozygotes, respectively. The distribution of the CYP3A4*1G allele was consistent with Hardy–Weinberg equilibrium (P > 0·05). At 2 and 4 h, the doses of fentanyl required for patients with GA/AA genotypes were 80·0 (45·0, 112·5) μg and 120·0 (80, 173·8) μg, respectively, and significantly lower than those for GG homozygotes [91·3 (80·0, 125·0) μg and 169·0 (112·5, 226·3) μg, respectively, P < 0·05]. There was trend of decreasing fentanyl consumption at 24 and 48 h in patients with GA/AA genotypes, relative to GG homozygotes, but the difference was not statistical significant (P > 0·05).
What is new and Conclusions: CYP3A4*1G has an impact on the analgesic effect of fentanyl in Chinese Han subjects. Further validation of our results in a well‐powered study would be helpful.</description><identifier>ISSN: 0269-4727</identifier><identifier>EISSN: 1365-2710</identifier><identifier>DOI: 10.1111/j.1365-2710.2011.01268.x</identifier><identifier>PMID: 21535061</identifier><identifier>CODEN: JCPTED</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Analgesia, Patient-Controlled - methods ; Analgesics, Opioid - administration & dosage ; Analgesics, Opioid - therapeutic use ; Asian Continental Ancestry Group - genetics ; Biological and medical sciences ; China ; Cytochrome P-450 CYP3A - genetics ; cytochrome P450 3A4 ; Female ; fentanyl ; Fentanyl - administration & dosage ; Fentanyl - therapeutic use ; Humans ; Hysterectomy - methods ; Infusions, Intravenous ; Medical sciences ; Middle Aged ; Pain, Postoperative - drug therapy ; patient-controlled analgesia ; Pharmacology. Drug treatments ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; single nucleotide polymorphisms ; Time Factors</subject><ispartof>Journal of clinical pharmacy and therapeutics, 2012-04, Vol.37 (2), p.153-156</ispartof><rights>2011 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2011 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5658-6a0990372697ae96b35135102877fdb60b7cf8d42f2a1606ebe039363ba3e1c13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2710.2011.01268.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2710.2011.01268.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25610861$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21535061$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dong, Z-L.</creatorcontrib><creatorcontrib>Li, H.</creatorcontrib><creatorcontrib>Chen, Q-X.</creatorcontrib><creatorcontrib>Hu, Y.</creatorcontrib><creatorcontrib>Wu, S-J.</creatorcontrib><creatorcontrib>Tang, L-Y.</creatorcontrib><creatorcontrib>Gong, W-Y.</creatorcontrib><creatorcontrib>Xie, G-H.</creatorcontrib><creatorcontrib>Fang, X-M.</creatorcontrib><title>Effect of CYP3A41G on the fentanyl consumption for intravenous patient-controlled analgesia after total abdominal hysterectomy in Chinese Han population</title><title>Journal of clinical pharmacy and therapeutics</title><addtitle>J Clin Pharm Ther</addtitle><description>Summary
What is known and Objective: Clinical investigations into postoperative intravenous patient‐controlled analgesia (PCA) have indicated interindividual differences in fentanyl consumption. Cytochrome P450 3A4 (CYP3A4) is the main metabolism enzyme of fentanyl, and single nucleotide polymorphisms within the CYP3A4 gene may contribute to the variability of fentanyl analgesic efficacy. The aim of this study was to investigate whether the most common genetic variation in Chinese, CYP3A4*1G, has an impact on the fentanyl consumption for intravenous PCA in Chinese Han women undergone abdominal total hysterectomy.
Methods: A total of 79 female patients (American Society of Anesthesiologist physical status I or II) scheduled to undergo elective abdominal total hysterectomy were enrolled. All patients received combined spinal–epidural anaesthesia with bupivacaine. Intravenous fentanyl PCA was provided postoperatively for satisfactory analgesia. The doses of fentanyl consumption were recorded 2, 4, 24 and 48 h after the initiation of PCA postoperatively. Pain at rest and adverse effects were measured with rating scales. CYP3A4*1G was screened by means of direct sequencing and further confirmed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP).
Results and Discussion: Forty‐six patients were GG homozygotes, 27 patients were GA heterozygotes, and six patients were AA homozygotes, respectively. The distribution of the CYP3A4*1G allele was consistent with Hardy–Weinberg equilibrium (P > 0·05). At 2 and 4 h, the doses of fentanyl required for patients with GA/AA genotypes were 80·0 (45·0, 112·5) μg and 120·0 (80, 173·8) μg, respectively, and significantly lower than those for GG homozygotes [91·3 (80·0, 125·0) μg and 169·0 (112·5, 226·3) μg, respectively, P < 0·05]. There was trend of decreasing fentanyl consumption at 24 and 48 h in patients with GA/AA genotypes, relative to GG homozygotes, but the difference was not statistical significant (P > 0·05).
What is new and Conclusions: CYP3A4*1G has an impact on the analgesic effect of fentanyl in Chinese Han subjects. Further validation of our results in a well‐powered study would be helpful.</description><subject>Adult</subject><subject>Analgesia, Patient-Controlled - methods</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biological and medical sciences</subject><subject>China</subject><subject>Cytochrome P-450 CYP3A - genetics</subject><subject>cytochrome P450 3A4</subject><subject>Female</subject><subject>fentanyl</subject><subject>Fentanyl - administration & dosage</subject><subject>Fentanyl - therapeutic use</subject><subject>Humans</subject><subject>Hysterectomy - methods</subject><subject>Infusions, Intravenous</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pain, Postoperative - drug therapy</subject><subject>patient-controlled analgesia</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide</subject><subject>single nucleotide polymorphisms</subject><subject>Time Factors</subject><issn>0269-4727</issn><issn>1365-2710</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kt-KEzEUxgdR3O7qK0hAxL2Zmj9NMnMjrHVtlUUXXFn0JpyZZmxqJhknGW3fxMc1s60VvDAEEs734zs55MsyRPCUpPViMyVM8JzKVKCYkCkmVBTT7b1schTuZxNMRZnPJJUn2WkIG4yxkJQ9zE4o4YxjQSbZr8um0XVEvkHzz9fsYkYWyDsU1xo12kVwO4tq78LQdtEkofE9Mi728EM7PwTUQTSJyxMTe2-tXiFwYL_qYABBE3WPoo9gEVQr35okofUupHJq6ttd8kLztXE6aLQEhzrfDRbGTo-yBw3YoB8fzrPs05vLm_kyv_qweDu_uMprLniRC8BliZlMk0rQpagYJ2ljWkjZrCqBK1k3xWpGGwpEYKErjVnJBKuAaVITdpY93_t2vf8-6BBVa0KtrQWn04CqpELMKGc0kef_JUkhaZGccZnQp_-gGz_0afiREoLPivTcRD05UEPV6pXqetNCv1N_ficBzw4AhBps04OrTfjLcUFwcce93HM_jdW7o06wGtOiNmoMhRpDoca0qLu0qK16N7--Ga_JIN8bmPQ126MB9N-UkExydft-ob7g5cfb11yoV-w3303B2w</recordid><startdate>201204</startdate><enddate>201204</enddate><creator>Dong, Z-L.</creator><creator>Li, H.</creator><creator>Chen, Q-X.</creator><creator>Hu, Y.</creator><creator>Wu, S-J.</creator><creator>Tang, L-Y.</creator><creator>Gong, W-Y.</creator><creator>Xie, G-H.</creator><creator>Fang, X-M.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Hindawi Limited</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201204</creationdate><title>Effect of CYP3A41G on the fentanyl consumption for intravenous patient-controlled analgesia after total abdominal hysterectomy in Chinese Han population</title><author>Dong, Z-L. ; Li, H. ; Chen, Q-X. ; Hu, Y. ; Wu, S-J. ; Tang, L-Y. ; Gong, W-Y. ; Xie, G-H. ; Fang, X-M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5658-6a0990372697ae96b35135102877fdb60b7cf8d42f2a1606ebe039363ba3e1c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Analgesia, Patient-Controlled - methods</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Analgesics, Opioid - therapeutic use</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biological and medical sciences</topic><topic>China</topic><topic>Cytochrome P-450 CYP3A - genetics</topic><topic>cytochrome P450 3A4</topic><topic>Female</topic><topic>fentanyl</topic><topic>Fentanyl - administration & dosage</topic><topic>Fentanyl - therapeutic use</topic><topic>Humans</topic><topic>Hysterectomy - methods</topic><topic>Infusions, Intravenous</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pain, Postoperative - drug therapy</topic><topic>patient-controlled analgesia</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single Nucleotide</topic><topic>single nucleotide polymorphisms</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dong, Z-L.</creatorcontrib><creatorcontrib>Li, H.</creatorcontrib><creatorcontrib>Chen, Q-X.</creatorcontrib><creatorcontrib>Hu, Y.</creatorcontrib><creatorcontrib>Wu, S-J.</creatorcontrib><creatorcontrib>Tang, L-Y.</creatorcontrib><creatorcontrib>Gong, W-Y.</creatorcontrib><creatorcontrib>Xie, G-H.</creatorcontrib><creatorcontrib>Fang, X-M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical pharmacy and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong, Z-L.</au><au>Li, H.</au><au>Chen, Q-X.</au><au>Hu, Y.</au><au>Wu, S-J.</au><au>Tang, L-Y.</au><au>Gong, W-Y.</au><au>Xie, G-H.</au><au>Fang, X-M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of CYP3A41G on the fentanyl consumption for intravenous patient-controlled analgesia after total abdominal hysterectomy in Chinese Han population</atitle><jtitle>Journal of clinical pharmacy and therapeutics</jtitle><addtitle>J Clin Pharm Ther</addtitle><date>2012-04</date><risdate>2012</risdate><volume>37</volume><issue>2</issue><spage>153</spage><epage>156</epage><pages>153-156</pages><issn>0269-4727</issn><eissn>1365-2710</eissn><coden>JCPTED</coden><abstract>Summary
What is known and Objective: Clinical investigations into postoperative intravenous patient‐controlled analgesia (PCA) have indicated interindividual differences in fentanyl consumption. Cytochrome P450 3A4 (CYP3A4) is the main metabolism enzyme of fentanyl, and single nucleotide polymorphisms within the CYP3A4 gene may contribute to the variability of fentanyl analgesic efficacy. The aim of this study was to investigate whether the most common genetic variation in Chinese, CYP3A4*1G, has an impact on the fentanyl consumption for intravenous PCA in Chinese Han women undergone abdominal total hysterectomy.
Methods: A total of 79 female patients (American Society of Anesthesiologist physical status I or II) scheduled to undergo elective abdominal total hysterectomy were enrolled. All patients received combined spinal–epidural anaesthesia with bupivacaine. Intravenous fentanyl PCA was provided postoperatively for satisfactory analgesia. The doses of fentanyl consumption were recorded 2, 4, 24 and 48 h after the initiation of PCA postoperatively. Pain at rest and adverse effects were measured with rating scales. CYP3A4*1G was screened by means of direct sequencing and further confirmed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP).
Results and Discussion: Forty‐six patients were GG homozygotes, 27 patients were GA heterozygotes, and six patients were AA homozygotes, respectively. The distribution of the CYP3A4*1G allele was consistent with Hardy–Weinberg equilibrium (P > 0·05). At 2 and 4 h, the doses of fentanyl required for patients with GA/AA genotypes were 80·0 (45·0, 112·5) μg and 120·0 (80, 173·8) μg, respectively, and significantly lower than those for GG homozygotes [91·3 (80·0, 125·0) μg and 169·0 (112·5, 226·3) μg, respectively, P < 0·05]. There was trend of decreasing fentanyl consumption at 24 and 48 h in patients with GA/AA genotypes, relative to GG homozygotes, but the difference was not statistical significant (P > 0·05).
What is new and Conclusions: CYP3A4*1G has an impact on the analgesic effect of fentanyl in Chinese Han subjects. Further validation of our results in a well‐powered study would be helpful.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21535061</pmid><doi>10.1111/j.1365-2710.2011.01268.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-4727 |
| ispartof | Journal of clinical pharmacy and therapeutics, 2012-04, Vol.37 (2), p.153-156 |
| issn | 0269-4727 1365-2710 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_926642532 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Analgesia, Patient-Controlled - methods Analgesics, Opioid - administration & dosage Analgesics, Opioid - therapeutic use Asian Continental Ancestry Group - genetics Biological and medical sciences China Cytochrome P-450 CYP3A - genetics cytochrome P450 3A4 Female fentanyl Fentanyl - administration & dosage Fentanyl - therapeutic use Humans Hysterectomy - methods Infusions, Intravenous Medical sciences Middle Aged Pain, Postoperative - drug therapy patient-controlled analgesia Pharmacology. Drug treatments Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide single nucleotide polymorphisms Time Factors |
| title | Effect of CYP3A41G on the fentanyl consumption for intravenous patient-controlled analgesia after total abdominal hysterectomy in Chinese Han population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T23%3A51%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20CYP3A41G%20on%20the%20fentanyl%20consumption%20for%20intravenous%20patient-controlled%20analgesia%20after%20total%20abdominal%20hysterectomy%20in%20Chinese%20Han%20population&rft.jtitle=Journal%20of%20clinical%20pharmacy%20and%20therapeutics&rft.au=Dong,%20Z-L.&rft.date=2012-04&rft.volume=37&rft.issue=2&rft.spage=153&rft.epage=156&rft.pages=153-156&rft.issn=0269-4727&rft.eissn=1365-2710&rft.coden=JCPTED&rft_id=info:doi/10.1111/j.1365-2710.2011.01268.x&rft_dat=%3Cproquest_pubme%3E1872836309%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1866548697&rft_id=info:pmid/21535061&rfr_iscdi=true |