The role of human leukocyte antigens as predisposing and/or protective factors in patients with idiopathic thrombotic thrombocytopenic purpura

The role of human leukocyte antigens as predisposing and/or protective factors in patients with idiopathic thrombotic thrombocytopenic purpura

Fifty-four adult German patients suffering from idiopathic thrombotic thrombocytopenic purpura (TTP) have been examined for HLA class II. All patients presented autoantibodies against ADAMTS13 and ADAMTS13 activity levels

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Veröffentlicht in:Annals of hematology 2012-04, Vol.91 (4), p.507-510
Hauptverfasser: John, Marie-Luise, Hitzler, Walter, Scharrer, Inge
Format: Artikel
Sprache:eng
Schlagworte:
ADAM Proteins - deficiency
ADAM Proteins - genetics
ADAM Proteins - immunology
ADAMTS13 Protein
Adult
Alleles
Autoantibodies
Blood donors
Bone marrow
Data processing
Disease Susceptibility
Female
Germany
Hematology
Histocompatibility antigen HLA
Histocompatibility Antigens Class II - genetics
HLA Antigens - genetics
HLA-DQ Antigens - genetics
HLA-DRB1 Chains - genetics
Humans
Male
Medicine
Medicine & Public Health
Oligonucleotides
Oncology
Original Article
Polymerase chain reaction
Primers
Purpura, Thrombotic Thrombocytopenic - genetics
Purpura, Thrombotic Thrombocytopenic - immunology
Purpura, Thrombotic Thrombocytopenic - physiopathology
Risk factors
Thrombotic thrombocytopenic purpura
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Beschreibung
Zusammenfassung:Fifty-four adult German patients suffering from idiopathic thrombotic thrombocytopenic purpura (TTP) have been examined for HLA class II. All patients presented autoantibodies against ADAMTS13 and ADAMTS13 activity levels
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-011-1384-z