Pharmacokinetics, Safety, and Tolerability of Atomoxetine and Effect of CYP2D610/10 Genotype in Healthy Japanese Men

Atomoxetine is a cytochrome P4502D6 (CYP2D6) substrate. The reduced-activity CYP2D6*10 allele is particularly prevalent in the Japanese population and may contribute to known ethnic differences in CYP2D6 metabolic capacity. The purpose of this study was to examine atomoxetine pharmacokinetics, safet...

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Veröffentlicht in:	Journal of clinical pharmacology 2012-03, Vol.52 (3), p.388-403
Hauptverfasser:	Matsui, A., Azuma, J., Witcher, J. W., Long, A. J., Sauer, J.-M., Smith, B. P., DeSante, K. A., Read, H. A., Takahashi, M., Nakano, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Uptake Inhibitors - adverse effects Adrenergic Uptake Inhibitors - pharmacokinetics Adult Area Under Curve Asian Continental Ancestry Group - genetics atomoxetine Atomoxetine Hydrochloride Cultural differences CYP2D6 Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2D6 - metabolism Dose-Response Relationship, Drug Drug Administration Schedule Gene Expression Regulation, Enzymologic Genotype Genotype & phenotype Half-Life Humans Japanese Male Men pharmacokinetics Propylamines - adverse effects Propylamines - pharmacokinetics safety Young Adult
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