Effect of polyamidoamine dendrimer G3 and G4 on skin permeation of 8-methoxypsoralene—In vivo study

In the present study we have assessed the ability of (PAMAM) dendrimers G3 and G4 to facilitate transdermal delivery of 8-methoxypsoralen (8-MOP) in vivo. In vitro study using Franz diffusion cell revealed an enhanced transdermal flux for 8-MOP in complex with G3 and G4 dendrimer in relation to stan...

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Veröffentlicht in:	International journal of pharmaceutics 2012-04, Vol.426 (1-2), p.280-283
Hauptverfasser:	Borowska, Katarzyna, Wołowiec, Stanisław, Rubaj, Andrzej, Głowniak, Kazimierz, Sieniawska, Elwira, Radej, Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	8-MOP Administration, Cutaneous Animals Chemistry, Pharmaceutical Chromatography, High Pressure Liquid confocal laser scanning microscopy Confocal microscopy Dendrimers - administration & dosage Dendrimers - chemistry Dendrimers - pharmacology dermis Drug Carriers Drug Compounding drugs high performance liquid chromatography in vitro studies in vivo studies Male methoxsalen Methoxsalen - administration & dosage Methoxsalen - chemistry Methoxsalen - pharmacokinetics Microscopy, Confocal Nanotechnology PAMAM dendrimers Permeability Photosensitizing Agents - administration & dosage Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacokinetics PUVA PUVA Therapy Rat skin permeation Rats Rats, Wistar Skin - drug effects Skin - metabolism Skin Absorption - drug effects Technology, Pharmaceutical - methods therapeutics
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