Cellular consequences of the expression of Alzheimer's disease-causing presenilin 1 mutations in human neuroblastoma (SH-SY5Y) cells

Abstract Mutations in the presenilin 1 (PS1) gene lead to early-onset Alzheimer's disease with the S170F mutation causing the earliest reported age of onset. Expression of this, and other PS1 mutations, in SH-SY5Y cells resulted in significant loss of cellular viability compared to control cell...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 2012-03, Vol.1443, p.75-88
Hauptverfasser:	Boyle, John P, Hettiarachchi, Nishani T, Wilkinson, Jenny A, Pearson, Hugh A, Scragg, Jason L, Lendon, Corinne, Al-Owais, Moza M, Kim, Cindy B, Myers, David M, Warburton, Philip, Peers, Chris
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Alzheimer disease Alzheimer's disease amyloid Amyloid beta-Peptides - metabolism Amyloid β mitochondria Biological and medical sciences brain Ca2 + homeostasis calcium Calcium - metabolism Cell Line, Tumor Cell Survival Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases endoplasmic reticulum genes Humans Medical sciences Mitochondria - metabolism mutants Mutation Neurology Organic mental disorders. Neuropsychology Presenilin-1 - genetics Presenilin-1 - metabolism Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry S170F PS1 mutation secretion SH-SY5Y viability
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!