Relationships between the islets blood flow, nitric oxide, insulin, and cytosolic calcium in rat pancreatic islets: Effects of DPP-IV inhibitor vildagliptin

Effects of DPP-IV inhibitor vildagliptin on the islets blood flow, nitric oxide, and insulin in normal and diabetic Wistar rats. The aim of the present study was to evaluate the relationships between the islets blood flow, nitric oxide, insulin, and cytosolic calcium in rat pancreatic islets, using...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2012-04, Vol.45 (5), p.546-551
Hauptverfasser:	Akarte, Atul sureshrao, Srinivasan, B.P., Gandhi, Sonia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - analogs & derivatives Adamantane - pharmacology Animals Biological and medical sciences Blood Glucose - drug effects Calcium - metabolism Cardiac Output - drug effects Cytokines - metabolism Cytosol - drug effects Cytosol - metabolism Cytosolic calcium Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetic rats Dipeptidyl-Peptidase IV Inhibitors - pharmacology General pharmacology Glucose - metabolism Hemodynamics - drug effects Insulin Insulin - blood Insulin - metabolism Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Islets blood flow Medical sciences Nitric oxide Nitric Oxide - metabolism Nitriles - pharmacology Peroxynitrous Acid - metabolism Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pyrrolidines - pharmacology Rats Rats, Wistar Regional Blood Flow - drug effects Vildagliptin
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